Clinical Trials for AIDS Dementia Complex

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for AIDS Dementia Complex is grouped into the following categories:-

• View by trial name
• View by drugs used in AIDS Dementia Complex clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for AIDS Dementia Complex:

• Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex - This study has been completed (Current: 23 Nov 2006) - Zidovudine,Didanosine
• A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection - This study has been completed (Current: 23 Nov 2006) - Zidovudine
• An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts - This study has been completed (Current: 23 Nov 2006) - Zidovudine
• Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 - This study has been completed (Current: 23 Nov 2006) - Nimodipine,Zidovudine
• A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC) - This study has been completed (Current: 23 Nov 2006) - Memantine
• A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases - This study has been completed (Current: 23 Nov 2006) - Zidovudine
• A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex - This study has been completed (Current: 23 Nov 2006) - Abacavir sulfate
• Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy - This study has been completed (Current: 23 Nov 2006) - CPI-1189
• A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex - This study is no longer recruiting patients (Current: 23 Nov 2006) - Stavudine
• Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia - This study is no longer recruiting patients (Current: 23 Nov 2006) - CPI-1189
• Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Selegiline hydrochloride
• A Study of Decreased Mental Function Associated With HIV - This study is no longer recruiting patients (Current: 23 Nov 2006) - Selegiline hydrochloride

Drugs used in Clinical Trials for AIDS Dementia Complex

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for AIDS Dementia Complex:

• Abacavir sulfate - A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex - This study has been completed (Current: 23 Nov 2006)
• CPI-1189 - Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy - This study has been completed (Current: 23 Nov 2006)
• CPI-1189 - Safety and Effectiveness of Giving CPI-1189 to HIV-Infected Patients With AIDS Dementia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Didanosine - Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex - This study has been completed (Current: 23 Nov 2006)
• Memantine - A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC) - This study has been completed (Current: 23 Nov 2006)
• Nimodipine - Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 - This study has been completed (Current: 23 Nov 2006)
• Selegiline hydrochloride - A Study of Decreased Mental Function Associated With HIV - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Selegiline hydrochloride - Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Stavudine - A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Zidovudine - A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) Infection - This study has been completed (Current: 23 Nov 2006)
• Zidovudine - A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases - This study has been completed (Current: 23 Nov 2006)
• Zidovudine - An Open Trial of Zidovudine (AZT) Treatment of the AIDS Dementia Complex in Patients With AIDS or Low CD4+ Lymphocyte Counts - This study has been completed (Current: 23 Nov 2006)
• Zidovudine - Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex - This study has been completed (Current: 23 Nov 2006)
• Zidovudine - Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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