Inheritance and Genetics of Alpers Syndrome

Inheritance of Alpers Syndrome:

Autosomal recessive diseases are usually inherited from both parents who are both usually symptom-free genetic carriers (i.e. neither has the disease). See inheritance of autosomal recessive diseases.

Alpers Syndrome: Inheritance and Genetics Details

Inheritance properties of Alpers Syndrome:

  Disease inherited from: Usually both parents who are symptom-free genetic carriers of Alpers Syndrome; see inheritance of autosomal recessive diseases.

  Gender bias in inheritance: Male or females get the disease equally.

Inheritance Patterns

Inheritance odds for Alpers Syndrome:

  Overall odds of inheritance: Usually both parents who are symptom-free genetic carriers of Alpers Syndrome; see inheritance of autosomal recessive diseases.

  Sibling of diseased child odds of inheriting disease: 25% usually for an autosomal recessive disease.

  Inheritance from one diseased parent odds: Usually 0% chance of disease, 100% chance of being a genetic carrier if one parent has an autosomal recessive disease (not just carrier).

  Inheritance from two diseased parents odds: 100%. Rare case where both parents are not carriers but actually have the autosomal recessive disease.

Genetic Carriers

Genetic carriers of Alpers Syndrome:

  Inheritance from one carrier parent odds: 0% approximately (cannot usually inherit the disease from one parent only).

  Inheritance from two carrier parents odds: 25% disease, 50% chance carrier, 25% neither for autosomal recessive diseases.

Inheritance Features

Inheritance features for Alpers Syndrome:

  Inheritance pattern: Inheritance patterns for autosomal recessive diseases tend to be "horizontal".

  Sporadic form of disease possible?: Very unlikely.

Alpers Syndrome: Genetics Information

Genetics of Alpers Syndrome: It is an autosomal recessive disorder that is sometimes seen in siblings. (Source: excerpt from NINDS Alpers' Disease Information Page: NINDS)

About inheritance and genetics:

Inheritance of Alpers Syndrome refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

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