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Amyloidosis

Amyloidosis: Introduction

Amyloidosis: Proteins are important building blocks for all body parts, including muscles, bones, hair, and nails. Proteins circulate throughout the ... more about Amyloidosis.

Amyloidosis: A rare group of metabolic disorders where a protein called amyloid accumulates in body organs and tissues where it can cause damage and is potentially fatal. Symptoms depend on the organs involved. There are numerous forms of the condition: primary amyloidosis, secondary amyloidosis, hemodialysis-associated amyloidosis and familial amyloidosis. More detailed information about the symptoms, causes, and treatments of Amyloidosis is available below.

Symptoms of Amyloidosis

Home Diagnostic Testing

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Wrongly Diagnosed with Amyloidosis?

Amyloidosis: Deaths

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Types of Amyloidosis

Amyloidosis: Complications

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Causes of Amyloidosis

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Disease Topics Related To Amyloidosis

Research the causes of these diseases that are similar to, or related to, Amyloidosis:

Misdiagnosis and Amyloidosis

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Amyloidosis: Research Doctors & Specialists

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Amyloidosis: Animations

Prognosis for Amyloidosis

Research about Amyloidosis

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Clinical Trials for Amyloidosis

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

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Statistics for Amyloidosis

Amyloidosis: Broader Related Topics

Amyloidosis Message Boards

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User Interactive Forums

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Article Excerpts about Amyloidosis

Amyloidosis and Kidney Disease: NIDDK (Excerpt)

Proteins are important building blocks for all body parts, including muscles, bones, hair, and nails. Proteins circulate throughout the body in the blood and are normally harmless. Occasionally, cells produce abnormal proteins that can settle in body tissue, forming deposits and causing disease. When these deposits of abnormal proteins were first discovered, they were called amyloid, and the disease process amyloidosis. (Source: excerpt from Amyloidosis and Kidney Disease: NIDDK)

Kidney Failure Glossary: NIDDK (Excerpt)

A condition in which a protein-like material builds up in one or more organs. This material cannot be broken down and interferes with the normal function of that organ. People who have been on dialysis for several years often develop amyloidosis because the artificial membranes used in dialysis fail to filter the protein-like material out of the blood. (Source: excerpt from Kidney Failure Glossary: NIDDK)

Definitions of Amyloidosis:

A disease characterised by the deposition of amyloid in various organs of the body. It is generally considered that the amyloidoses share common pathogenic mechanisms which lead to protein fibril formation and deposition. These mechanisms may include structural, metabolic, genetic and environmental factors that may be common to all forms of amyloidosis. Primary amyloidosis, while the most common form of amyloidosis, is a sporadic disease and, therefore, can only be investigated on a case by case basis. Secondary (reactive) amyloidosis occurs in subjects with chronic inflammatory disease or cancer but factors which predict amyloid formation and which subject is going to be affected, are not readily apparent. Alzheimer disease, while very common in the aged population, is unpredictable except for those rare forms of familial Alzheimer disease with characterized mutations in specific genes. Hereditary transthyretin amyloidosis has generally been considered a rare disease and the original impetus to study the pathogenesis of this disease was because it represented a human model of systemic amyloidosis. - (Source - Diseases Database)

A disorder characterized by deposit of amyloid in organs or tissues; often secondary to chronic rheumatoid arthritis or tuberculosis or multiple myeloma - (Source - WordNet 2.1)

Amyloidosis is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Amyloidosis, or a subtype of Amyloidosis, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Amyloidosis as a "rare disease".
Source - Orphanet

 

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