Diagnostic Tests for Arthritis

Contents

Tests and diagnosis discussion for Arthritis:

Questions and Answers About Arthritis and Rheumatic Diseases: NIAMS (Excerpt)

Diagnosing rheumatic diseases can be difficult because some symptoms and signs are common to many different diseases. A general practitioner or family doctor may be able to evaluate a patient or refer him or her to a rheumatologist: a doctor who specializes in treating arthritis and other rheumatic diseases.

The doctor will review the patient’s medical history, conduct a physical examination, and obtain laboratory tests and X rays or other imaging tests. The doctor may need to see the patient more than once to make an accurate diagnosis.

Medical History

It is vital for people with joint pain to give the doctor a complete medical history. Answers to the following questions will help the doctor make an accurate diagnosis:

Is the pain in one or more joints?
When does the pain occur?
How long does the pain last?
When did you first notice the pain?
What were you doing when you first noticed the pain?
Does activity make the pain better or worse?
Have you had any illnesses or accidents that may account for the pain?
Is there a family history of any arthritis or rheumatic diseases?
What medicine(s) are you taking?

It may be helpful for people to keep a daily journal that describes the pain. Patients should write down what the affected joint looks like, how it feels, how long the pain lasts, and what they were doing when the pain started.

Physical Examination and Laboratory Tests

The doctor will examine all of the patient’s joints for redness, warmth, deformity, ease of movement, and tenderness. Because some forms of arthritis, such as lupus, may affect other organs, a complete physical examination including the heart, lungs, abdomen, nervous system, and eyes, ears, and throat may be necessary. The doctor may order some laboratory tests to help confirm a diagnosis. Samples of blood, urine, or synovial

Common Laboratory Tests

Antinuclear antibody (ANA)—This test checks blood levels of antibodies that are often present in people who have connective tissue diseases or other autoimmune disorders, such as lupus. Since the antibodies react with material in the cell’s nucleus (control center), they are referred to as antinuclear antibodies. There are also tests for individual types of ANA’s that may be more specific to people with certain autoimmune disorders. ANA’s are also sometimes found in healthy people. Therefore, having ANA’s in the blood does not necessarily mean that a person has a disease.
Arthrocentesis—Arthrocentesis or joint aspiration is done to obtain a sample of synovial fluid. The doctor injects a local anesthetic, inserts a thin, hollow needle into the joint, and removes the synovial fluid into a syringe. The test provides important diagnostic information. For example, the test allows the doctor to see whether crystals (found in patients with gout or other types of crystal-induced arthritis) or bacteria or viruses (found in patients with infectious arthritis) are present in the joint.
Complement—This test measures the level of complement, a group of proteins in the blood. Complement helps destroy foreign substances, such as germs, that enter the body. A low blood level of complement is common in people who have active lupus.
Complete blood count (CBC)—This test determines the number of white blood cells, red blood cells, and platelets present in a sample of blood. Some rheumatic conditions or drugs used to treat arthritis are associated with a low white blood count (leukopenia), low red blood count (anemia), or low platelet count (thrombocytopenia). When doctors prescribe medications that affect the CBC, they periodically test the patient’s blood.
Creatinine—This blood test is commonly ordered in patients who have rheumatic diseases to monitor for underlying kidney disease.
Erythrocyte sedimentation rate (sed rate)—This blood test is used to detect inflammation in the body. Higher sed rates indicate the presence of inflammation and are typical of many forms of arthritis, such as rheumatoid arthritis and ankylosing spondylitis, and many of the connective tissue diseases.
Hematocrit (PCV, packed cell volume)—This test and the test for hemoglobin (a substance in the red blood cells that carries oxygen through the body) measure the number of red blood cells present in a sample of blood. A decrease in the number of red blood cells (anemia) is common in people with inflammatory arthritis and rheumatic diseases.
Rheumatoid factor—This test determines whether rheumatoid factor is present in the blood. Rheumatoid factor is an antibody found in the blood of most (but not all) people who have rheumatoid arthritis. Rheumatoid factor may be found in many other diseases besides rheumatoid arthritis, and sometimes in normal, healthy people.
Urinalysis—In this test, a urine sample is studied for protein, red blood cells, white blood cells, or casts. These abnormalities indicate kidney disease, which may be seen in several rheumatic diseases such as lupus or vasculitis. Some medications used to treat arthritis can also cause abnormal findings on urinalysis.
White blood cell count (WBC)—This test determines the number of white blood cells present in a sample of blood. The number may increase as a result of infection or decrease in response to certain medications, or with certain diseases, such as lupus. Low numbers of white blood cells increase a person’s risk of infections.

(Source: excerpt from Questions and Answers About Arthritis and Rheumatic Diseases: NIAMS)

Questions and Answers About Arthritis and Rheumatic Diseases: NIAMS (Excerpt)

X Rays and Other Imaging Procedures

To see what the joint looks like inside, the doctor may order X rays or other imaging procedures. X rays provide an image of the bones, but they do not show the cartilage, muscles, and ligaments. Other noninvasive imaging methods such as computed tomography (CT or CAT), magnetic resonance imaging (MRI), and arthrography (joint X ray) show the whole joint. The doctor may also use an arthroscope (a small, flexible tube that transmits the image of the inside of a joint to a video screen) to examine damage to a joint. The arthroscope is inserted into the affected joint through a very small incision in the skin. This procedure, called arthroscopy, allows the doctor to see inside the joint. Doctors also use arthroscopy to perform surgery for some types of joint injury. (Source: excerpt from Questions and Answers About Arthritis and Rheumatic Diseases: NIAMS)