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Glossary for Autoimmune disorders -- Teratogenic Agent

  • 18p minus syndrome: A rare chromosomal disorder where a portion of chromosome 18 is missing which is characterized by mental and growth deficiencies, drooping upper eyelid and prominent ears. The type and severity of symptoms is determined by the amount of genetic material that is missing.
  • 22q11.2 deletion syndrome: A rare genetic disorder caused by the absence of a small portion of genetic material. A small section of chromosome 22 is missing at a location called q11.2. Chromosome 22 is one of 23 pairs of chromosomes that exist in humans.
  • Allergic Disorders: A group of disorders that a caused by an allergic response to allergens
  • Chromosome 18, Monosomy 18p: A rare chromosomal disorder where a portion of chromosome 18 is missing which is characterized by mental and growth deficiencies, drooping upper eyelid and prominent ears. The type and severity of symptoms is determined by the amount of genetic material that is missing.
  • Chromosome 18p minus syndrome: A rare genetic disorder where a portion of the genetic material from the short arm of chromosome18 is missing. The symptoms or severity may vary somewhat between patients.
  • Chromosome 22q deletion: A rare genetic disorder where a portion of the genetic material from the long arm of chromosome 22 is missing. The symptoms or severity may vary somewhat between patients.
  • Chromosome 22q11.2 deletion syndrome: A rare genetic disorder caused by the absence of a small portion of genetic material. A small section of chromosome 22 is missing at a location called q11.2. Chromosome 22 is one of 23 pairs of chromosomes that exist in humans.
  • Complement component 2 deficiency: A rare disorder where a deficiency of a compound called complement component 2 impairs the bodies ability to fight infection and autoimmune disorders.
  • Congenital heart block: A rare congenital heart disease where a slowed heart rate is caused by defects in the heart conduction system. The condition is usually asymptomatic and harmless but in severe cases (complete AV block) various symptoms and sudden death may occur.
  • Hypothyroidism: Too little thyroid hormone production.
  • Immune disorders: Disorders that affect the immune system
  • Leukeran -- Teratogenic Agent: There is evidence to indicate that exposure to Leukeran (a chemotherapy drug) during pregnancy may have a teratogenic effect on the fetus. A teratogen is a substance that can cause birth defects. The likelihood and severity of defects may be affected by the level of exposure and the stage of pregnancy that the exposure occurred at.
  • Pregnancy-related conditions: Any condition that is related to or caused by pregnancy
  • Primary immunodeficiency disorders: A defective immune system not caused by a disease or virus but rather due to a genetic mutation. Many different cells in the body are involved in the body's immune system and thus there are over 100 different primary immunodeficiency disorders. B cells, T cells, natural killer cells and phagocytic cells are some of the cells that make up the immune system. Symptoms can range from mild to severe. Primary immunodeficiencies may occur on their own or as part of a syndrome.
  • Teratogen-related conditions: Medical conditions related to "teratogens", i.e. substances that can cause birth defects by fetal exposure.

 

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