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Causes of Autoimmune Lymphoproliferative Syndrome

Autoimmune Lymphoproliferative Syndrome: Related Medical Conditions

To research the causes of Autoimmune Lymphoproliferative Syndrome, consider researching the causes of these these diseases that may be similar, or associated with Autoimmune Lymphoproliferative Syndrome:

Autoimmune Lymphoproliferative Syndrome: Causes and Types

Causes of Broader Categories of Autoimmune Lymphoproliferative Syndrome: Review the causal information about the various more general categories of medical conditions:

What causes Autoimmune Lymphoproliferative Syndrome?

Article excerpts about the causes of Autoimmune Lymphoproliferative Syndrome:
To better understand how ALPS works, imagine that you have a respiratory infection, perhaps the flu. The cells in the nose and throat send out a message to the immune system to start making more lymphocytes to fight the flu. New troops of lymphocytes come to the nose and throat to seek out and destroy the cells infected with the flu virus. Once the virus is conquered, the lymphocytes get a message that their job is done and they are no longer needed. At this point, it is normal for most of the fighter cells to disintegrate through a process called apoptosis (a-pop-to'-sis).

The immune systems of people with ALPS are efficient in fighting germs. The problem in ALPS happens after an infection is gone. In ALPS, apoptosis does not work as well as it should. In other words, the troops (lymphocytes) donŐt hear the message that the war is over. As a result, excess T and B cells gather in the lymph glands, liver and spleen. We can detect the extra cells in people with ALPS by looking for high numbers of double-negative T cells. In general, these extra T cells donŐt cause a problem.

Sometimes in ALPS, the B cells make a mistake. Instead of making antibodies to be custom-designed against germs, the B cells make antibodies against platelets, red blood cells, or other cells. This causes autoimmune problems. The antibodies become stuck to the platelets and red blood cells, which then get stuck in the spleen. The spleen has to work extra hard to filter out the sticky cells. This is another reason why the spleen gets so big. (Source: excerpt from Autoimmune Lymphoproliferative Syndrome (ALPS): NIAID)

Related information on causes of Autoimmune Lymphoproliferative Syndrome:

As with all medical conditions, there may be many causal factors. Further relevant information on causes of Autoimmune Lymphoproliferative Syndrome may be found in:

 

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