Inheritance and Genetics of Autosomal dominant polycystic kidney disease
Inheritance of Autosomal dominant polycystic kidney disease:
Autosomal dominant diseases are usually inherited from the one parent who already has the disease. Rare cases of sporadic genetic disease with neither parent having the disease can also occur. See inheritance of autosomal dominant diseases.
Genetics of Autosomal dominant polycystic kidney disease:
Autosomal dominant polycystic kidney disease is a genetic disease that exhibits autosomal dominant inheritance.
Autosomal dominant polycystic kidney disease: Inheritance and Genetics Details
Inheritance properties of Autosomal dominant polycystic kidney disease:
Disease inherited from:
Usually inherited from one parent who has Autosomal dominant polycystic kidney disease; see inheritance of autosomal dominant diseases.
Gender bias in inheritance:
Male and female children are equally at risk of autosomal dominant diseases.
Inheritance Patterns
Inheritance odds for Autosomal dominant polycystic kidney disease:
Overall odds of inheritance:
Usually inherited from one parent who has Autosomal dominant polycystic kidney disease; see inheritance of autosomal dominant diseases.
Sibling of diseased child odds of inheriting disease:
Usually 50% for autosomal dominant diseases.
Overall odds of inheriting from mother:
Usually 50% for autosomal dominant diseases.
Overall odds of inheriting from father:
Usually 50% for autosomal dominant diseases.
Mother to son inheritance odds:
Usually 50% for autosomal dominant diseases.
Father to son inheritance odds:
Usually 50% for autosomal dominant diseases.
Mother to daughter inheritance odds:
Usually 50% for autosomal dominant diseases.
Father to daughter inheritance odds:
Usually 50% for autosomal dominant diseases.
Inheritance from one diseased parent odds:
Usually 50% for autosomal dominant diseases.
Inheritance from two diseased parents odds:
Usually 75% (50% disease, 25% double dominant) for autosomal dominant diseases.
Genetic Carriers
Genetic carriers of Autosomal dominant polycystic kidney disease:
Carriers possible for disease?:
No, not for autosomal dominant diseases.
Odds daughter becomes genetic carrier:
0%. There are no carriers for autosomal dominant diseases.
Odds son becomes genetic carrier:
0%. There are no carriers for autosomal dominant diseases.
Inheritance Features
Inheritance features for Autosomal dominant polycystic kidney disease:
Inheritance pattern:
Vertical inheritance for autosomal dominant disease.
Sporadic form of disease possible?:
Yes, only one genetic mutation is required for a sporadic version of an autosomal dominant disease.
Double dominant form of disease possible?:
Yes, double dominance is definitely applicable for autosomal dominance.
Inheritance from one double dominant parent:
Usually 100% inheritance from a double dominant form of an autosomal dominant disease.
Inheritance and Genetics Information
Inheritance of Autosomal dominant polycystic kidney disease:
The phrase "autosomal dominant" means that if one parent has the disease,
there is a 50-percent chance that the disease will pass to a child (see Genetic
Diseases ). At least one parent must have the disease for a child to
inherit it. Either the mother or father can pass it along, but new
mutations may account for one-fourth of new cases. In some rare cases, the
cause of autosomal dominant PKD occurs spontaneously in the child soon
after conception--in these cases the parents are not the source of this
disease.
(Source: excerpt from Polycystic Kidney Disease: NIDDK)
About inheritance and genetics:
Inheritance of Autosomal dominant polycystic kidney disease refers to whether the condition is inherited
from your parents or "runs" in families.
The level of inheritance of a condition depends
on how important genetics are to the disease.
Strongly genetic diseases are usually inherited,
partially genetic diseases are sometimes inherited,
and non-genetic diseases are not inherited.
For general information, see Introduction to Genetics.
