Clinical Trials for Beta thalassemia
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Beta thalassemia is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Beta thalassemia:
- 5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia - This study has been completed (Current: 23 Nov 2006) - 5-Azacytidine
- Study of Deferasirox in Iron Overload From Beta-Thalassemia Unable to Be Treated With Deferoxamine or Chronic Anemias - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
- Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia) - This study has been completed (Current: 23 Nov 2006) - Hydroxyurea
- Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferitrin (GT56-252),desferoxamine (DFO)
- Combined Chelation Treatment With Deferiprone and Deferoxamine in Thalassemia Major - This study is no longer recruiting patients (Current: 23 Nov 2006) - deferiprone
- Evaluating the Safety of G-CSF Mobilization in Individuals With Beta Thalassemia Major - This study is currently recruiting patients (Current: 23 Nov 2006) - G-CSF (filgrastim),Hydroxyurea
- Extension Study on Efficacy and Safety of Deferasirox Treatment in Patients With Beta-Thalassemia and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006) - ICL670; deferasirox
- Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia - This study has been completed (Current: 23 Nov 2006) - arginine butyrate,epoetin alfa
- Stem Cell Transplantation (SCT) for Genetic Diseases - This study has been completed (Current: 23 Nov 2006)
- Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders - This study has been completed (Current: 23 Nov 2006) - anti-thymocyte globulin,busulfan,cyclophosphamide
- Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major - This study has been completed (Current: 23 Nov 2006)
- Phase II Study of Azacitidine and Phenylbutyrate in Patients With Thalassemia Major - This study has been terminated (Current: 23 Nov 2006) - azacitidine,phenylbutyrate
- Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone - This study has been completed (Current: 23 Nov 2006) - chelation therapy
- Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis - This study has been completed (Current: 23 Nov 2006) - deferoxamine
- Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN) - This study is currently recruiting patients (Current: 23 Nov 2006) - Pamidronate,Ribavirin,Deferoxamine,Deferiprone,Arginine
- Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006) - Sangstat,Cyclophosphamide,Busulfan,Mycophenolate Mofetil,Cyclosporine
- Safety & Efficacy of ICL670 Vs. Deferoxamine in Beta-Thalassemia Patients With Iron Overload Due to Blood Transfusions - This study has been completed (Current: 23 Nov 2006) - ICL670,deferoxamine
- Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - Deferoxamine,Deferiprone
- Genetic Factors Affecting the Severity of Beta Thalassemia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Busulfex,fludarabine
- Efficacy Study in Removing Excess Iron From the Heart - This study has been completed (Current: 23 Nov 2006) - Ferriprox (deferiprone),Desferal (deferoxamine)
- A Study of Efficacy and Safety of Long-Term Treatment With Deferasirox in Patients With Beta-Thalassemia and Transfusional Hemosiderosis - This study is no longer recruiting patients (Current: 23 Nov 2006) - deferasirox
- Iron Chelation Therapy With Deferasirox in -Thalassemia Major Pediatric Patients With Transfusional Iron Overload - This study is no longer recruiting patients (Current: 23 Nov 2006) - Deferasirox
- Examination of Protective Factors Against Severe Malaria - This study is currently recruiting patients (Current: 23 Nov 2006)
- Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers - This study is currently recruiting patients (Current: 23 Nov 2006) - arginine butyrate
- Study of Nonmyeloablative Allogeneic Bone Marrow Transplantation in Patients With High Risk Hemoglobinopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - Anti-thymocyte globulin,busulfan,Cyclosporine,Fludarabine,mycophenolate mofetil
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Beta thalassemia:
The trial data on this page has been sourced from
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