Clinical Trials for Chronic Bronchitis
Clinical trials are research studies conducted in an effort to improve overall patient health and care.
Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition.
Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks.
A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.
A brief description of each phase:
- Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
- Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
- Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
- Phase IV: These studies monitor long-term side effects after the treatment has been marketed.
Clinical Trials data for Chronic Bronchitis is grouped into the following categories:-
The format for each of the following is:
- The name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
- followed by a list of drug/s, if any, used in the trial
ClinicalTrials.gov has listed the following trials for Chronic Bronchitis:
- A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD - This study has been completed (Current: 23 Nov 2006) - ABX-IL8
- A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
- A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
- A Study of the Effectiveness and Safety of High Dose, Short-Course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis. - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin, azithromycin, amoxicillin/clavulanate
- Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006) - IV amikacin,PO azithromycin,IV ceftazidime,PO ciprofloxacin,IV meropenem,IV piperacillin-tazobactam,IV ticarcillin-clavulanate,IV tobramycin
- Study of Expectorant Activity of Oral N-Acetylcystein (NAC) in Patients With Stable Chronic Bronchitis - This study has been completed (Current: 23 Nov 2006) - Oral N-acetycystein (NAC)
- Evaluating Genes in Sputum to Measure Drug Response in COPD - This study is no longer recruiting patients (Current: 23 Nov 2006) - Salmeterol or Salmeterol/Fluticasone
- Phase 2 Study - Erdosteine in Patients With CB/COPD - This study is currently recruiting patients (Current: 23 Nov 2006) - Erdosteine
- Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals - This study has been completed (Current: 23 Nov 2006)
- COPD on Primary Care Treatment (COOPT) - This study has been completed (Current: 23 Nov 2006) - N-acetylcysteine,fluticasone propionate
- Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006) - all macrolide antibiotics,all beta-lactam antibiotics
- Outpatient Registry Trial of Respiratory Tract Infections in Adults - This study has been suspended (Current: 23 Nov 2006) - azithromycin,telithromycin
- A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Azithromycin SR,Moxifloxacin
- Telithromycin in Acute Exacerbation of Chronic Bronchitis. - This study is currently recruiting patients (Current: 23 Nov 2006) - Telithromycin
- Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) - This study has been completed (Current: 23 Nov 2006)
- Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD - This study has been completed (Current: 23 Nov 2006) - (R,R)-Formoterol
- To Evaluate the Long-Term Safety of (R,R)-Formoterol in Subjects With COPD - This study has been completed (Current: 23 Nov 2006) - (R,R)-formoterol
- PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis - This study is currently recruiting patients (Current: 23 Nov 2006) - telithromycin
- KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-Acquired Lower Respiratory Tract Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - telithromycin
- Regulation of the Release of Inflammatory Mediators From Lung Macrophages. - This study is currently recruiting patients (Current: 23 Nov 2006)
- Leukocyte Function in Asthma and COPD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Inhaled Steroid Reduces Systemic Inflammation in COPD - This study has been completed (Current: 23 Nov 2006) - inhaled fluticasone 500 mcg b.i.d
- Airway Clearance for Prevention of COPD Exacerbation - This study is currently recruiting patients (Current: 23 Nov 2006)
- Double-Blind Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Telithromycin, Placebo and faropenem medoxomil
- Macrophage Phagocytosis in COPD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Macrophages in Smokers' Lung - This study is currently recruiting patients (Current: 23 Nov 2006)
- Emphysema Research Registry - This study is currently recruiting patients (Current: 23 Nov 2006)
- Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Real-Time Support for Exercise Persistence in COPD - This study is currently recruiting patients (Current: 23 Nov 2006)
- The Effect of QVAR on Lung Functioning in Chronic Obstructive Pulmonary Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - HFA-134A Beclomethasone DIpropionate (QVAR)
- A Study to Assess the Safety and Efficacy of Different AD 237 Doses in Adults With COPD - This study has been completed (Current: 23 Nov 2006) - AD 237
- GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) - This study is currently recruiting patients (Current: 23 Nov 2006) - fluticasone propionate/salmeterol combination DISKUS™
- Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) - This study is currently recruiting patients (Current: 23 Nov 2006) - fluticasone propionate/salmeterol combination DISKUS™,salmeterol xinafoate
- Comparison of Two Programs to Encourage Physical Activity in Individuals With Chronic Obstructive Pulmonary Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Identifying Inflammatory Biomarkers of Chronic Obstructive Pulmonary Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Safety and Efficacy Study of Arformoterol Tartrate Inhalation Solution in the Treatment of Subjects With Chronic Obstructive Pulmonary Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Arformoterol tartrate inhalation solution
The format for each of the following is:
- The drug,
- followed by the name of the trial,
- followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
ClinicalTrials.gov has listed the following drugs in trials for Chronic Bronchitis:
- (R,R)-Formoterol - Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD - This study has been completed (Current: 23 Nov 2006)
- (R,R)-formoterol - To Evaluate the Long-Term Safety of (R,R)-Formoterol in Subjects With COPD - This study has been completed (Current: 23 Nov 2006)
- ABX-IL8 - A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD - This study has been completed (Current: 23 Nov 2006)
- AD 237 - A Study to Assess the Safety and Efficacy of Different AD 237 Doses in Adults With COPD - This study has been completed (Current: 23 Nov 2006)
- All Beta-Lactam Antibiotics - Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006)
- All Macrolide Antibiotics - Outcomes of Patients Not Responding to Antibiotics in the Community - This study has been completed (Current: 23 Nov 2006)
- Arformoterol tartrate inhalation solution - Safety and Efficacy Study of Arformoterol Tartrate Inhalation Solution in the Treatment of Subjects With Chronic Obstructive Pulmonary Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- Azithromycin SR - A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- Azithromycin - Outpatient Registry Trial of Respiratory Tract Infections in Adults - This study has been suspended (Current: 23 Nov 2006)
- Erdosteine - Phase 2 Study - Erdosteine in Patients With CB/COPD - This study is currently recruiting patients (Current: 23 Nov 2006)
- Fluticasone Propionate/Salmeterol Combination Diskus™ - Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Fluticasone Propionate/Salmeterol Combination Diskus™ - GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Fluticasone Propionate - COPD on Primary Care Treatment (COOPT) - This study has been completed (Current: 23 Nov 2006)
- HFA-134A Beclomethasone DIpropionate (QVAR) - The Effect of QVAR on Lung Functioning in Chronic Obstructive Pulmonary Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV amikacin - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV ceftazidime - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV meropenem - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV piperacillin-tazobactam - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV ticarcillin-clavulanate - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- IV tobramycin - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- Inhaled Fluticasone 500 Mcg B.I.D. - Inhaled Steroid Reduces Systemic Inflammation in COPD - This study has been completed (Current: 23 Nov 2006)
- Levofloxacin, Azithromycin, Amoxicillin/Clavulanate - A Study of the Effectiveness and Safety of High Dose, Short-Course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis. - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Levofloxacin - A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Levofloxacin - A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Moxifloxacin - A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
- N-acetylcysteine - COPD on Primary Care Treatment (COOPT) - This study has been completed (Current: 23 Nov 2006)
- Oral N-acetycystein (NAC) - Study of Expectorant Activity of Oral N-Acetylcystein (NAC) in Patients With Stable Chronic Bronchitis - This study has been completed (Current: 23 Nov 2006)
- PO azithromycin - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- PO ciprofloxacin - Standard Vs. Biofilm Susceptibility Testing in CF - This study is currently recruiting patients (Current: 23 Nov 2006)
- Salmeterol Xinafoate - Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) - This study is currently recruiting patients (Current: 23 Nov 2006)
- Salmeterol or Salmeterol/Fluticasone - Evaluating Genes in Sputum to Measure Drug Response in COPD - This study is no longer recruiting patients (Current: 23 Nov 2006)
- Telithromycin, Placebo and faropenem medoxomil - Double-Blind Trial to Evaluate the Efficacy and Safety of Faropenem Medoxomil In the Treatment of Chronic Bronchitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Telithromycin - KEYS: Study Comparing Clinical Health Outcomes of Telithromycin Versus Azithromycin in Outpatients With Community-Acquired Lower Respiratory Tract Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
- Telithromycin - Outpatient Registry Trial of Respiratory Tract Infections in Adults - This study has been suspended (Current: 23 Nov 2006)
- Telithromycin - PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis - This study is currently recruiting patients (Current: 23 Nov 2006)
- Telithromycin - Telithromycin in Acute Exacerbation of Chronic Bronchitis. - This study is currently recruiting patients (Current: 23 Nov 2006)
The trial data on this page has been sourced from
