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What is Common Variable Immunodeficiency?

What is Common Variable Immunodeficiency?

  • Common Variable Immunodeficiency: An immunodeficiency disorder involving low blood gamma globulin levels which results in an increased susceptibility to infections. The condition may be inherited or can be caused by certain drugs (levamisole, hydantoin and carbamazepine).
  • Common Variable Immunodeficiency: Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.
    Source - Diseases Database

Common Variable Immunodeficiency is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Common Variable Immunodeficiency, or a subtype of Common Variable Immunodeficiency, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Common Variable Immunodeficiency as a "rare disease".
Source - Orphanet

Common Variable Immunodeficiency: Introduction

Types of Common Variable Immunodeficiency:

Broader types of Common Variable Immunodeficiency:

Who gets Common Variable Immunodeficiency?

Patient Profile for Common Variable Immunodeficiency: Usually teens or young adults; infants or children also possible.

Profile for Common Variable Immunodeficiency: Infants sometimes have symptoms of CVI, though in most cases symptoms do not show up until the second or third decade of life. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

How serious is Common Variable Immunodeficiency?

Complications of Common Variable Immunodeficiency: see complications of Common Variable Immunodeficiency

What causes Common Variable Immunodeficiency?

Causes of Common Variable Immunodeficiency: see causes of Common Variable Immunodeficiency
Cause of Common Variable Immunodeficiency: Unknown. Probably not genetic as no clear inheritance patterns.
Causes of Common Variable Immunodeficiency: CVI has no clear pattern of inheritance. The cause is unknown. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

What are the symptoms of Common Variable Immunodeficiency?

Symptoms of Common Variable Immunodeficiency: see symptoms of Common Variable Immunodeficiency

Complications of Common Variable Immunodeficiency: see complications of Common Variable Immunodeficiency

Onset of Common Variable Immunodeficiency: highly variable, from infancy to later adulthood

Can anyone else get Common Variable Immunodeficiency?

More information: see contagiousness of Common Variable Immunodeficiency
Inheritance: see inheritance of Common Variable Immunodeficiency

Common Variable Immunodeficiency: Testing

Diagnostic testing: see tests for Common Variable Immunodeficiency.

Misdiagnosis: see misdiagnosis and Common Variable Immunodeficiency.

How is it treated?

Treatments for Common Variable Immunodeficiency: see treatments for Common Variable Immunodeficiency
Research for Common Variable Immunodeficiency: see research for Common Variable Immunodeficiency

Organs Affected by Common Variable Immunodeficiency:

Organs and body systems related to Common Variable Immunodeficiency include:

Name and Aliases of Common Variable Immunodeficiency

Main name of condition: Common Variable Immunodeficiency

Other names or spellings for Common Variable Immunodeficiency:

CVID, hypogammaglobulinemia, adult-onset agammaglobulinemia, late-onset hypogammaglobulinemia, acquired agammaglobulinemia, Common variable hypogammaglobulinemia, Hypogammaglobulinemia, acquired, Immunoglobulin deficiency, late-onset

Non-familial hypogammaglobulinaemia, Common variable hypogammaglobulinaemia Source - Diseases Database

CVID, Common variable hypogammaglobulinemia, Hypogammaglobulinemia, acquired, Immunoglobulin deficiency, late-onset, Common variable hypogammaglobulinemia, Hypogammaglobulinemia, acquired, Immunoglobulin deficiency, late-onset
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Common Variable Immunodeficiency: Related Conditions

Research the causes of these diseases that are similar to, or related to, Common Variable Immunodeficiency:

 

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