This section presents information about the death rate statistics
for the various types of Connective tissue disorders.
Disease | Death Rate Estimate | US deaths estimate | Statistic Used for Calculation |
| Scleroderma |
N/A |
N/A |
estimated 300,000 Americans (NWHIC)
|
| SLE |
N/A |
N/A |
1.4 million people in the United States, 1 in 85 (NWHIC)
|
| Rheumatoid arthritis |
N/A |
N/A |
2.5 million Americans (NWHIC); 1% of US population (NIAMS)
|
| Sjögren's syndrome |
N/A |
N/A |
1 to 4 million people with Sjogren’s Syndrome (NIAMS)
|
| Heritable Disorders of Connective Tissue |
N/A |
N/A |
estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
|
| Ehlers-Danlos syndrome |
N/A |
N/A |
estimated 1 per 250,000 people suffer from the vascular type of Ehlers-Danlos syndrome, Genetics Home Reference website
|
| Epidermolysis bullosa |
N/A |
N/A |
No information
|
| Marfan syndrome |
N/A |
N/A |
1 per 5,000 people are affected by Marfan syndrome worldwide, Genetics Home Reference website
|
| Osteogenesis imperfecta |
N/A |
N/A |
6-7 per 100,000 people are affected by osteogenesis imperfecta worldwide, Genetics Home Reference website
|
| Generalized connective tissue syndrome |
N/A |
N/A |
No information
|
| Liposarcoma |
N/A |
N/A |
No information
|
| Fibrosarcoma |
N/A |
N/A |
No information
|
| Soft Tissue Sarcoma |
unavailable |
|
No information
|
| Sarcoma |
N/A |
N/A |
No information
|
| Leiomyosarcoma |
N/A |
N/A |
No information
|
| Collagenopathy, COL3 |
N/A |
N/A |
No information
|
| Collagenopathy, COL4 |
N/A |
N/A |
No information
|
| Collagenopathy, COL5 |
N/A |
N/A |
No information
|
| Collagenopathy, COL6 |
N/A |
N/A |
No information
|
| Collagenopathy, COL7 |
N/A |
N/A |
No information
|
| Collagenopathy, COL8 |
N/A |
N/A |
No information
|
| Collagenopathy, COL9 |
N/A |
N/A |
No information
|
| Collagenopathy, COL10 |
N/A |
N/A |
No information
|
| Collagenopathy, COL11 |
N/A |
N/A |
No information
|
| Collagenopathy, COL17 |
N/A |
N/A |
No information
|
| Collagenopathy, COL1 |
N/A |
N/A |
No information
|
| Collagenopathy, type 2 alpha 1 |
N/A |
N/A |
No information
|
| Cutis laxa |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 12 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 11 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 10 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 9 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 8 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 7 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 6 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 5 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 4 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 3 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 2 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 1 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus with Vitiligo, Susceptibility to, 1 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus with Hemolytic Anemia, Susceptibility to, 1 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus with Nephritis, Susceptibility to, 1 |
N/A |
N/A |
No information
|
| Systemic Lupus Erythematosus, Susceptibility to, 13 |
N/A |
N/A |
No information
|
| Scleroderma Associated with Thymus Hyperplasia |
N/A |
N/A |
No information
|
| Localized Scleroderma |
N/A |
N/A |
No information
|
| Morphea |
N/A |
N/A |
No information
|
| Lupus |
N/A |
N/A |
1.4 million people in the United States, 1 in 85 (NWHIC)
|
| Discoid lupus erythematosus |
N/A |
N/A |
No information
|
| Neonatal lupus |
N/A |
N/A |
very rare
|
| Mixed connective tissue disease |
N/A |
N/A |
No information
|
| Discoid Lupus |
N/A |
N/A |
No information
|
| Chronic Discoid lupus |
N/A |
N/A |
No information
|
| Subacute cutaneous lupus erythematosus |
N/A |
N/A |
No information
|
| Systemic lupus erythematoses |
N/A |
N/A |
No information
|
| Bullous systemic lupus erythematosus |
N/A |
N/A |
No information
|
| Lupus erythematosus tumidus |
N/A |
N/A |
No information
|
| Subcutaneous lupus erythematosus psoariasiform type |
N/A |
N/A |
No information
|
| Lupus nephritis |
N/A |
N/A |
No information
|
| Winchester Syndrome |
N/A |
N/A |
No information
|
| Marfan Syndrome type 2 |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, Beasley Cohen type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, progeroid form |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome with periventricular heterotopia |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 2A |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type IIB |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type VIII |
N/A |
N/A |
No information
|
| Weak bones similar to that of osteogenesis imperfecta |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type V |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type X |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, 6B |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, hypermobile type |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 1A |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 1B |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, hypermobility type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, progeroid form 2 |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type II |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, arthrochalasic type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type VIII |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type VI |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type IV |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type IX |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, vascular type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, dermatospraxis type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, kyphoscoliosis type |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta Type I |
N/A |
N/A |
3-4 per 100,000 people are affected by osteogenesis imperfecta type I worldwide, Genetics Home Reference website
|
| Ehlers-Danlos syndrome, tenascin-X deficiency |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, cardiac valvular form |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type III |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, classic type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome Type I |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, X-linked |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, VIIB |
N/A |
N/A |
No information
|
| Ehlers-Danlos Syndrome, Dysfibronectinemic type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome with Platelet Dysfunction from Fibronectin Abnormality |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type VII |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome caused by tenascin-X deficiency |
N/A |
N/A |
No information
|
| Ehlers Danlos syndrome type 4, autosomal dominant |
N/A |
N/A |
No information
|
| Ehlers-Danlos, syndrome, periodontitis type |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type 3 |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome type 4 |
N/A |
N/A |
No information
|
| Ehlers-Danlos syndrome, dermatosparaxis type |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, Type VI |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta -- congenital joint contractures |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 2 |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 3 |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 4 |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 5 |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, type 6 |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta, Levin type |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta type IIII |
N/A |
N/A |
1-2 per 100,000 people are affected by osteogenesis imperfecta type IIII worldwide, Genetics Home Reference website
|
| Osteogenesis imperfecta type IV |
N/A |
N/A |
3-4 per 100,000 people are affected by osteogenesis imperfecta type IV worldwide, Genetics Home Reference website
|
| Osteogenesis imperfecta, type 7 |
N/A |
N/A |
No information
|
| CREST syndrome |
N/A |
N/A |
No information
|
| Eosinophilic fasciitis |
N/A |
N/A |
No information
|
| Fibrosis |
N/A |
N/A |
No information
|
| Human adjuvant disease |
N/A |
N/A |
No information
|
| Acute rheumatic fever |
unavailable |
|
No information
|
| Plexosarcoma |
N/A |
N/A |
No information
|
| Rhabdomyosarcoma, Botryoid type |
N/A |
N/A |
No information
|
| Rheumatism |
N/A |
N/A |
No information
|
| Infantile Fibrosarcoma |
N/A |
N/A |
No information
|
| Synovial sarcoma |
N/A |
N/A |
No information
|
| Adult Fibrosarcoma |
N/A |
N/A |
No information
|
| Rhabdomyosarcoma of the orbit |
N/A |
N/A |
No information
|
| Rhabdomyosarcoma |
N/A |
N/A |
No information
|
| Acroosteolysis dominant type |
N/A |
N/A |
No information
|
| Hajdu-Cheney Syndrome |
N/A |
N/A |
No information
|
| Cutis laxa, recessive type 1 |
N/A |
N/A |
No information
|
| Cutis laxa, recessive type 2 |
N/A |
N/A |
No information
|
| Cutis laxa, recessive |
N/A |
N/A |
No information
|
| Cutis laxa, dominant type |
N/A |
N/A |
No information
|
| Cutis laxa -- osteoporosis |
N/A |
N/A |
No information
|
| Cutis Laxa, Autosomal Dominant |
N/A |
N/A |
No information
|
| Cutis Laxa with or without Congenital Disorder of Glycosylation |
N/A |
N/A |
No information
|
| Cutis Laxa, Debre Type |
N/A |
N/A |
No information
|
| Cutis Laxa with Bone Dystrophy |
N/A |
N/A |
No information
|
| Cutis Laxa with Growth and Developmental Delay |
N/A |
N/A |
No information
|
| Cutis Laxa, Autosomal Recessive, Type IIA |
N/A |
N/A |
No information
|
| Cutis Laxa, Autosomal Recessive, Type IIB |
N/A |
N/A |
No information
|
| Cutis laxa congenital |
N/A |
N/A |
No information
|
| Rheumatic fever |
unavailable |
|
No information
|
| Scleroderma, linear |
N/A |
N/A |
No information
|
| Inheritable disorders of connective tissue |
N/A |
N/A |
No information
|
| Myxoid liposarcoma |
N/A |
N/A |
No information
|
| Dermatofibrosarcoma protuberans |
N/A |
N/A |
No information
|
| SLE associated with Thymus Hyperplasia |
N/A |
N/A |
No information
|
| Marfanoid syndrome, da Silva type |
N/A |
N/A |
No information
|
| OI, Type I |
N/A |
N/A |
No information
|
| Meigel Disease |
N/A |
N/A |
No information
|
| Alport Syndrome |
N/A |
N/A |
1 per 50,000 newborns suffer from Alport syndrome, Genetics Home Reference website
|
| Juvenile Scleroderma |
N/A |
N/A |
No information
|
| Arterial tortuosity syndrome |
N/A |
N/A |
No information
|
| Larsen-like syndrome, lethal form |
N/A |
N/A |
No information
|
| Pseudoxanthoma elasticum, recessive form |
N/A |
N/A |
No information
|
| Larsen-like syndrome, lethal type |
N/A |
N/A |
No information
|
| Pseudoxanthoma elasticum, dominant form |
N/A |
N/A |
No information
|
| Pseudoxanthoma elasticum, forme fruste |
N/A |
N/A |
No information
|
| Pseudoxanthoma elasticum |
N/A |
N/A |
1 per 25,000 - 100,000 people are affected by pseudoxanthoma elasticum, Genetics Home Reference website
|
| Marfanoid hypermobility |
N/A |
N/A |
No information
|
| Osteogenesis imperfecta congenita, microcephaly, and cataracts |
N/A |
N/A |
No information
|
| Connective tissue dysplasia, Spellacy type |
N/A |
N/A |
No information
|
| Scleroderma, diffuse |
N/A |
N/A |
No information
|
| Scleroderma, systemic |
N/A |
N/A |
No information
|
| Scleroderma sine scleroderma |
N/A |
N/A |
No information
|
| Gerodermia osteodysplastica |
N/A |
N/A |
No information
|
| Gerodermia osteodysplasticum |
N/A |
N/A |
No information
|
| Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency |
N/A |
N/A |
No information
|
| Leigh syndrome, Saguenay-Lac-St. Jean type |
N/A |
N/A |
No information
|
| Scleromyxedema |
N/A |
N/A |
No information
|
| Gronblad-Strandberg-Touraine syndrome |
N/A |
N/A |
No information
|
| Gerodermia osteodysplastica hereditaria |
N/A |
N/A |
No information
|
| Geroderma osteodysplastica |
N/A |
N/A |
No information
|
| Fibronectin-Deficient EDS |
N/A |
N/A |
No information
|
| Saguenay-Lac Saint Jean -- COX deficiency |
N/A |
N/A |
No information
|
| Macrodactyly -- Hemihypertrophy -- Connective tissue nevi syndrome |
N/A |
N/A |
No information
|
| REST syndrome |
N/A |
N/A |
No information
|
| Macleod-Fraser syndrome |
N/A |
N/A |
No information
|
| Marfan-like syndrome, Boileau type |
N/A |
N/A |
No information
|
| Marphanoid syndrome, type De Silva |
N/A |
N/A |
No information
|
| Marfan-Like syndrome |
N/A |
N/A |
No information
|
| MASS syndrome |
N/A |
N/A |
No information
|
| Brittle bone syndrome lethal type |
N/A |
N/A |
No information
|
| Strudwick syndrome |
N/A |
N/A |
only a few cases of the condition have been reported, Genetics Home Reference website
|
| Achard syndrome |
N/A |
N/A |
No information
|
| Fibrosing Mediastinitis idiopathic |
N/A |
N/A |
No information
|
| Loewenthal syndrome |
N/A |
N/A |
No information
|
| Beals syndrome |
N/A |
N/A |
No information
|
