Dubin-Johnson Syndrome: A rare inherited condition where impaired metabolism of bilirubin results in chronic mild jaundice. More detailed information about the symptoms, causes, and treatments of Dubin-Johnson Syndrome is available below.
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Chronic liver disease often undiagnosed: One study reported that 50% of patients with a chronic liver disease remain undiagnosed by their primary physician. The reasons are...read more »
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Types of Dubin-Johnson Syndrome
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A benign, autosomally recessive inherited hyperbilirubinemia characterized by the presence of a dark pigment in the centrilobular region of the liver cells. There is a functional defect in biliary excretion of bilirubin, cholephilic dyes, and porphyrins. Affected persons may be asymptomatic or have vague constitutional or gastrointestinal symptoms. The liver may be slightly enlarged, and oral and intravenous cholangiography fails to visualize the biliary tract. - (Source - Diseases Database)
Dubin-Johnson Syndrome is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Dubin-Johnson Syndrome, or a subtype of Dubin-Johnson Syndrome,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Dubin-Johnson Syndrome as a "rare disease".
Source - Orphanet
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