Assessment
Questionnaire

Have a symptom?
See what questions
a doctor would ask.
 

Inheritance and Genetics of Duchenne Muscular Dystrophy

Inheritance of Duchenne Muscular Dystrophy:

X-linked recessive diseases are usually inherited by males from their mother. Rare cases of sporadic genetic disease can also occur. See inheritance of x-linked recessive diseases.

Genetics of Duchenne Muscular Dystrophy:

Duchenne muscular dystrophy is a genetic disease that exhibits X-linked recessive inheritance. Approximately one-third of cases are due to spontaneous dystrophin mutations.

Duchenne Muscular Dystrophy: Inheritance and Genetics Details

Inheritance properties of Duchenne Muscular Dystrophy:

  Disease inherited from: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

  Gender bias in inheritance: Males only get x-linked recessive diseases; females are carriers.

Inheritance Patterns

Inheritance odds for Duchenne Muscular Dystrophy:

  Overall odds of inheritance: Usually inherited by males from their mother who is a carrier; see inheritance of x-linked recessive diseases.

  Sibling of diseased child odds of inheriting disease: About 50% for a second child if one (male) child already has the x-linked recessive disease.

  Mother to son inheritance odds: 50% disease, 50% disease-free, males cannot be a carrier of an x-linked recessive disease.

  Father to son inheritance odds: 0% chance usually for x-linked recessive diseases.

  Mother to daughter inheritance odds: 0% disease; 50% female carrier, 50% chance neither affected nor carrier.

  Father to daughter inheritance odds: 0% chance of x-linked recessive disease; 100% chance the female child is a carrier.

Inheritance Features

Inheritance features for Duchenne Muscular Dystrophy:

  Sporadic form of disease possible?: Yes, requires single mutation for x-linked recessive disease.

  Milder form of disease possible in females?: Yes, females have mild disease for some x-linked recessive diseases.

Duchenne Muscular Dystrophy: Genetics Information

Genetics of Duchenne Muscular Dystrophy: The gene for DMD, found on the X chromosome, encodes a large protein --- dystrophin. Dystrophin is required inside muscle cells for structural support; it is thought to strengthen muscle cells by anchoring elements of the internal cytoskeleton to the surface membrane. Without it, the cell membrane becomes permeable, so that extracellular components enter the cell, increasing the internal pressure until the muscle cell "explodes" and dies. The subsequent immune response can add to the damage. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Duchenne Muscular Dystrophy refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

 

By using this site you agree to our Terms of Use. Information provided on this site is for informational purposes only; it is not intended as a substitute for advice from your own medical team. The information on this site is not to be used for diagnosing or treating any health concerns you may have - please contact your physician or health care professional for all your medical needs. Please see our Terms of Use.

Home | Symptoms | Diseases | Diagnosis | Videos | Tools | Forum | About Us | Terms of Use | Privacy Policy | Site Map | Advertise