A genetic recessive disease that affects muscles causing progressive and degenerative muscle weakness. It is caused by a mutation in the dystrophin gene that creates a protein that anchors muscle fibers in cells. ...more »
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Duchenne muscular dystrophy (DMD) is one of a group of muscular dystrophies characterized by the enlargement of muscles. DMD is one of the most prevalent types of muscular dystrophy and is characterized by rapid progression of muscle degeneration that occurs early in life. (Source: Genes and Disease by the National Center for Biotechnology)
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415) - (Source - Diseases Database)
Duchenne Muscular Dystrophy is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Duchenne Muscular Dystrophy, or a subtype of Duchenne Muscular Dystrophy,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
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