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Diseases » Foot conditions » Glossary
 

Glossary for Foot conditions

  • ACPS III: A rare genetic condition characterized by head and digital anomalies as well as other abnormalities.
  • ADULT syndrome: A rare syndrome characterized by nail abnormalities, abnormal teeth development, tear duct obstruction, pigmentation anomalies and hand and foot abnormalities.
  • Abuelo Forman Rubin Syndrome: A rare condition where a blood disorder called alpha-thalassemia is associated with hand and foot defects and genital abnormalities.
  • Acanthokeratodermia: An uncommon skin condition involving excessive growth of the horny part of the skin on the palms of the hands and soles of the feet. Patients also suffer thickening of the nails.
  • Acanthosis nigricans muscle cramps acral enlargement: A rare syndrome characterized mainly by muscle cramps, dark velvety patches of skin and large hands and feet.
  • Accessory navicular bone: An abnormal bone that develops in the arch in the middle of the foot. Often there are no symptoms but if the bone is large it may rub against shoes and cause problems.
  • Achard syndrome: An inherited connective tissue disorder characterized primarily by a short head, long, slender bones, recessed lower jaw and loose hand and foot joints.
  • Acheiropodia: A rare birth defect where infants are born without hands or feet.
  • Achilles tendinitis: A condition which is characterized by inflammation and tenderness located in the Achilles tendon of the leg
  • Achilles tendon contracture: A condition which is characterized by permanent contracture of the Achilles tendon of the leg
  • Achilles tendonitis: Condition causing pain and inflammation in the insertion point of the Achilles tendon, usually due to activities causing repeated stress on the tendon
  • Acquired Acroosteolysis, phalangeal type: A medical term for the slowly progressive destruction of the distal end of bones in the hands and feet. The condition may be inherited or may be acquired in occupations involving polyvinylcholoride plastic material.
  • Acral dysostosis -- dyserythropoiesis: A rare disorder characterized by hand and foot defects as well as a congenital form of anemia characterized by the production of abnormal red blood cells.
  • Acral lentiginous melanoma: Acral lentigous melanoma is the most common variant of skin cancer seen in dark-skinned people. This form of melanoma appears on the palms of the hands, the soles of the feet, or on nails. Lesions are usually brown, black, or multicolored with irregular borders, and flat or nodular.
  • Acro-reno-ocular syndrome: A disorder characterized by eye abnormalities, kidney defects and abnormalities of the arm and hand bones.
  • Acrocallosal Syndrome (Schinzel Type): A rare condition characterized by absence of portion of the brain (corpus callosum), mental deficiency, duplicated toes, mental deficiency and other abnormalities.
  • Acrocallosal syndrome: A rare genetic disorder characterized by underdeveloped or absent corpus callosum of brain, duplication of thumb or big toe and extra fingers or toes.
  • Acrocephalopolydactyly: A rare genetic condition characterized by limb abnormalities, extra digits and hydrocephalus. Other additional symptoms are variably present.
  • Acrocephalopolydactyly -- Cardiac Disease -- Ear, Skin and Lower Limb Defects: A rare genetic condition characterized by head and digital anomalies as well as other abnormalities.
  • Acrocephalopolysyndactyly type III: A rare genetic condition characterized by head and digital anomalies as well as other abnormalities.
  • Acrocephalopolysyndactyly, type 2 (ACPS 2): A rare genetic disorder characterized by premature closing of skull bones, craniofacial abnormalities, heart defects, growth retardation and other disorders.
  • Acrocephalosyndactyly: A group of inherited disorders characterized by abnormalities involving the skull, face, hands and feet. Apert, Pfeiffer and Crouzon syndrome are examples of various types of the disorder.
  • Acrocephalosyndactyly II: A rare inherited disorder characterized primarily by premature closure of skull bones, fusion of fingers and toes and eye and face abnormalities.
  • Acrocephalosyndactyly Syndrome type 5: A rare genetic disorder where some of the skull bones fuse too early which affects the size and shape of the skull and face. Thumb and toe abnormalities are also present. There are three types of Pfeiffer syndrome with varying degrees of severity.
  • Acrocephalosyndactyly type 3 (ACPS 3): A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include brachycephaly, ear deformities as well as craniofacial, finger and bone abnormalities.
  • Acrocephalosyndactyly type 5 (ACPS 5): A rare genetic disorder where some of the skull bones fuse too early which affects the size and shape of the skull and face. Thumb and toe abnormalities are also present. There are three types of Pfeiffer syndrome with varying degrees of severity.
  • Acrocyanosis: An uncommon disorder of blood vessels, causing cold, pale skin.
  • Acrodysostosis: A rare genetic disorder characterized by short hands, small nose, mental deficiency and hand and foot deformities.
  • Acrodysplasia scoliosis: A rare inherited genetic disorder characterized by short fingers and toes, scoliosis and other spine anomalies.
  • Acrofacial dysostosis -- ambiguous genitalia: A rare disorder characterized mainly by ambiguous genitals and abnormal development of bones in the face, jaw, hands and feet.
  • Acrofacial dysostosis atypical postaxial: A rare genetic disorder characterized by absence of some fingers and toes and characteristic facial features.
  • Acrofacial dysostosis autosomal recessive: A rare inherited disorder characterized mainly by facial, hand and foot anomalies. The disorder resembles Nager syndrome.
  • Acrofacial dysostosis postaxial, atypical: A rare disorder characterized by an unusual facial appearance, short stature and hand and foot bone anomalies. The disorder may be related to the fact that the infants were born to mothers with diabetes.
  • Acrofacial dysostosis, Weyers type: A rare disorder characterized by facial abnormalities and extra digits, nail abnormalities and short limbs.
  • Acrokeratoelastoidosis of Costa: A rare condition characterized by yellowish or flesh-colored papules or plaques which have a flat top.
  • Acromelanosis: A birth anomaly where there is patches of increased pigmentation in the ends of the fingers and toes. The pigmentation may spread to surrounding areas of skin.
  • Acromesomelic dysplasia Hunter Thompson type: A rare genetic syndrome characterized by various severe developmental abnormalities of the skeletal bones.
  • Acromesomelic dysplasia, Maroteaux type: A rare genetic syndrome characterized by various developmental abnormalities of the skeletal bones and facial anomalies.
  • Acroosteolysis: A medical term for the slowly progressive destruction of the distal end of bones in the hands and feet. The condition may be inherited or may be acquired in occupations involving polyvinylcholoride plastic material.
  • Acroosteolysis dominant type: A rare inherited connective tissue disorder characterized by breakdown of bone especially in the ends of the fingers and toes.
  • Acroosteolysis, phalangeal type: A medical term for the slowly progressive destruction of the distal end of bones in the hands and feet. The condition may be inherited or may be acquired in occupations involving polyvinylcholoride plastic material.
  • Acropectoral syndrome: A rare disorder characterized by extra fingers and toes, fusion of fingers and toes and anomalies involving the abdominal and chest wall.
  • Acropectorovertebral dysplasia: A rare inherited genetic disorder characterized by abnormalities involving the fingers, toes, palate and chest bones.
  • Acropustulosis: Acropustulosis is a recurrent, self-limited, pruritic, vesiculopustular eruption of the palms and soles
  • Acrorenal mandibular syndrome: A very rare condition characterized by a split hand or foot deformity, kidney abnormalities and underdeveloped lower jaw.
  • Acrorenal syndrome: A rare lethal syndrome characterized limb anomalies and kidney malformations.
  • Acrorenal syndrome recessive: A rare, recessively inherited disorder characterized by the association of kidney and hand and foot abnormalities.
  • Acrosphenosyndactylia: A rare condition characterized by abnormalities in the appearance of the face and head as well as finger and toe abnormalities. The bones of the skull fuse together too early which prevents it from growing normally. Various toes and fingers may be fused together.
  • Ainhum: A rare condition where a tough band of tissue tightens around a body part and causes it to fall off (autoamputation). Mostly seen in barefooted Africans where the fifth toe autoamputates.
  • Al Awadi syndrome: A rare syndrome characterized primarily by severe malformations involving the limbs and pelvis.
  • Al Awadi-Raas-Rothschild syndrome: A rare syndrome characterized primarily by severe malformations involving the limbs and pelvis. The exact type and severity of symptoms is variable. Most cases appear to occur in cases where the parents were related.
  • Alajouanine syndrome: A birth disorder characterized mainly by clubfoot, strabismus and facial paralysis. The facial paralysis is caused by damage to the 6th and 7th cranial nerve.
  • Albright like syndrome: A rare disorder characterized by mental retardation, short stature and finger and toe abnormalities.
  • All Disease Categories: All major disease categories
  • Alopecia congenita keratosis palmoplantaris: An extremely rare condition characterized by thickening of skin on the palms and soles and lack of hair.
  • Alopecia universalis -- onychodystrophy -- vitiligo: A rare syndrome characterized by the association of total hair loss, vitiligo and abnormal nails.
  • Amelo-onycho-hypohidrotic syndrome: A rare disorder characterized primarily by tooth and nail abnormalities and reduced sweating ability.
  • Ampola syndrome: A rare genetic disease characterized primarily by mental retardation, facial anomalies, short stature, seizures and finger and toe abnormalities.
  • Anonychia: An inherited condition where an infant is born without fingernails and toe nails. The finger bones were normal.
  • Anonychia -- ectrodactyly: A very rare syndrome characterized by the absence of nails and the absence of all or part of one or more fingers or toes (ectrodactyly).
  • Anonychia -- onychodystrophy: A rare birth malformation characterized by absent nails and dystrophic nails.
  • Anonychia onychodystrophy brachydactyly type b: A rare, dominantly inherited disorder characterized abnormal or absent nails, permanently flexed fingers and a broad, finger-like thumb.
  • Anonychia with flexural pigmentation: A rare disorder characterized by missing nails and areas of increased and decreased pigmentation in the groin and armpits.
  • Anonychia-onychodystrophy with brachydactyly type B and ectrodactyly: A rare, dominantly inherited disorder characterized abnormal or absent nails, missing fingers, permanently flexed fingers and a broad, finger-like thumb.
  • Anophthalmia -- hand and foot defects -- mental retardation: A rare syndrome characterized mainly by mental retardation, hand and foot defects and absent eyes.
  • Apert syndrome: A rare condition characterized by abnormalities in the appearance of the face and head as well as finger and toe abnormalities. The bones of the skull fuse together too early which prevents it from growing normally. Various toes and fingers may be fused together.
  • Aplasia/hypoplasia of pelvis, femur, fibula, and ulna with abnormal digits and nails: A rare syndrome characterized by the underdevelopment or absence of the pelvis, thigh bone, shin bone and ulna (forearm bone) as well as digital and nail abnormalities.
  • Arachnodactyly -- Intellectual Deficit -- Dysmorphism: A rare condition characterized by long thin digits, reduced intelligence characteristic facial appearance.
  • Arachnodactyly -- mental retardation -- dysmorphism: A very rare syndrome characterized by mental retardation, unusual facial features and long, thin fingers and toes.
  • Arthritis: General name for any type of joint inflammation, but often means age-related osteoarthritis.
  • Athlete's foot: Fungal skin condition typically of feet or toes.
  • Aural atresia -- multiple congenital anomalies -- mental retardation: A rare syndrome characterized by a number of malformations as well as mental retardation.
  • BOD syndrome: A very rare syndrome characterized primarily by small nails, digital abnormalities (mainly of the fifth finger and toe) and various facial anomalies.
  • Banki syndrome: A rare disorder characterized by abnormal curvature of fingers, thin middle sections of long bones, fusion of certain wrist bones (lunate and cuneiform bones) and other hand abnormalities.
  • Barnicoat-Baraitser syndrome: A rare syndrome characterized mainly by extra digits and excessive growth resulting in an increased birth weight and size.
  • Bartsocas Papa syndrome: A rare condition characterized by webbing of skin as well as various other physical and mental abnormalities.
  • Beardwell syndrome: A very rare syndrome characterized primarily by abnormal calcium deposits along the vertebrae as well as the development of calluses on the palms and soles.
  • Bennion-Patterson Syndrome: A condition characterized by thickening of the skin on the palms of the hands and soles of the feet as well as an increased risk of developing gastrointestinal cancer which increases with age.
  • Berndorfer syndrome: A rare syndrome characterized mainly by a cleft palate, harelip and cleft hands and feet.
  • Biemond Syndrome: A rare genetic disorder characterized by nystagmus, cerebellar ataxia and short digits.
  • Biemond syndrome type 1: A rare inherited condition characterized by mental retardation, finger and toe abnormalities, obesity and eye problems.
  • Biemond syndrome type 2: A rare inherited condition characterized by mental retardation, obesity, polydactyly and underdeveloped genitals.
  • Biemond syndrome type 3: A rare inherited condition characterized by the inability to feel pain as well as other anomalies.
  • Blepharophimosis, ptosis, polythelia and brachydactyly: A rare syndrome characterized mainly by droopy eyelids, short digits, blepharophimosis and accessory nipples (polythelia).
  • Brachydactylous dwarfism, Mseleni type: A very rare syndrome characterized primarily by progressive joint disease, short stature and short fingers and toes. The joint disease affects mainly the hips, knees, ankles and spine. The condition can eventually lead to disability and hip and/or knee replacements in serious cases.
  • Brachydactyly -- anonychia: A rare syndrome characterized by short toes and nail abnormalities.
  • Brachydactyly -- arterial hypertension: A rare syndrome characterized by the association of hypertension with short digits. Premature death (by the fifth decade) due to stroke occurs in untreated patients.
  • Brachydactyly -- mesomelia -- mental retardation -- heart defects: A rare genetic disorder characterized by mental retardation, heart defects, short digits and short limbs.
  • Brachydactyly nystagmus cerebellar ataxia: A very rare syndrome characterized mainly by short digits, nystagmus and cerebellar ataxia.
  • Brachydactyly preaxial with hallux varus and thumb abduction: A rare digital anomaly characterized by short thumbs and big toes which are also abducted (angled away from the foot or hand).
  • Brachydactyly type A1: A rare inherited malformation characterized primarily by shortness or absence of middle bones of fingers and toes.
  • Brachydactyly type A2: A very rare digital anomaly characterized by shortened middle bones of the second finger (index finger) and second toe. These fingers and toes are also often angled abnormally.
  • Brachydactyly type A6: A rare limb malformation disorder characterized by underdeveloped or absent middle bones in fingers and toes as well as shortened limbs and short stature.
  • Brachydactyly type C: A rare malformation characterized primarily by variable deformities involving the two sections closest to the hand of the second and third fingers.
  • Brachydactyly type D: A digital defect where the ends of the thumbs and toes are abnormally short and broad.
  • Brachydactyly type E: A rare condition characterized by short metacarpals and metatarsals - hand bones that lead to the fingers.
  • Brachydactyly types B and E combined: A rare hand anomaly characterized by shortening of one or more metacarpals (hand bones) as well as an underdeveloped end bone in the little finger
  • Brachydactyly with hypertension: A very rare disease characterized by the association of hypertension with brachydactyly (abnormally short fingers and/or toes).
  • Brachydactyly, type A5, nail dysplasia: A rare digital anomaly where the middle bones of the second to fifth fingers are missing and the nails are abnormal.
  • Brachydactyly, type B2: A rare dominantly inherited hand and foot malformation involving varying degrees of absence or underdevelopment of the ends of the fingers and toes as well as fusion of bones in the wrist and ankle.
  • Brachymesophalangy 2 and 5: A rare genetic disorder characterized by short middle bones of the second and fifth fingers and toes.
  • Brachymetapody, anodontia, hypotrichosis, albinoidism: A rare syndrome characterized by short foot bones, total absence of teeth, reduced amount of hair and lack of skin pigmentation.
  • Brachymetatarsalia: A medical term used to describe the shortening of one or more metatarsals which are bones that run through the foot to the toes.
  • Brachymetatarsalism: A medical term used to describe the shortening of one or more metatarsals which are bones that run through the foot to the toes.
  • Brachymetatarsus IV: A rare birth defect where the fourth toe (next to the smallest toe) is abnormally short. The shortness of the toe is actually due to a short foot bone that leads to the fourth toe.
  • Brailsford: A rare inherited skeletal disorder characterized by short hand and foot bones which may also be deformed. Other anomalies are also present.
  • Braun-Bayer syndrome: A familial disorder involving deafness, split uvula, short thumbs and toes and kidney problems.
  • Broken foot: Fracture of one or more foot bones
  • Broken toe: Fracture of a bone in a toe
  • Bruck syndrome: A very rare syndrome characterized primarily by weak, brittle bones and abnormal knee, ankle and foot joints (congenital contractures) at birth. There are two different subtypes of the disorder, each with a different genetic defect origin.
  • Bruck syndrome 1: A very rare syndrome characterized primarily by weak, brittle bones and abnormal knee, ankle and foot joints (congenital contractures) at birth.
  • Brugsch's syndrome: A rare syndrome characterized by small hands and feet as well as thickened skin on the hands, feet, scalp and face.
  • Bruyn-Scheltens syndrome: A rare syndrome characterized by limb weakness and muscle wasting in the hands and feet.
  • Buerger's disease: Buergers's disease is a recurring inflammation and thrombosis (clotting) of small and medium arteries and veins of the hands and feet
  • Bunionette: Enlargment of the lateral aspect of the fifth metatarsal head.
  • Bunions: Bony growth on the big toe.
  • Burning feet syndrome: Abnormal burning and stinging sensations in the feet which may be accompanied by redness and swelling. It may be caused by factors such as kidney failure, liver damage, thyroid problems, blood disorders, nerve damage, fungal infections, chronic alcoholism and ill-fitting shoes. In some cases, the eyes may also be affected
  • Buttiens-Fryns syndrome: A rare genetic disorder characterized by a small jaw, small mouth and defects involving the hands and feet.
  • CHILD syndrome ichthyosis: A rare genetic disorder characterized by unilateral hypomelia, underdeveloped skin and heart defects.
  • Callosities, hereditary painful: A rare skin inherited condition characterized by the development of painful calluses over pressure points in the hands and feet. Occasionally blisters filled with a foul-smelling liquid form around the calluses.
  • Callus: Thickening of skin on hands or feet.
  • Camptobrachydactyly: A rare hand and foot abnormality where the fingers and toes are unusually short and the first part of the fingers or toes are held in a fixed contracted position.
  • Camptodactyly -- fibrous tissue hyperplasia -- skeletal dysplasia: A rare syndrome characterized by a hand deformity and skeletal abnormalities.
  • Camptodactyly syndrome, Guadalajara type 1: A rare syndrome characterized mainly by retarded fetal growth and permanently flexed fingers as well as other abnormalities such as short toes, short neck and a small head.
  • Camptodactyly syndrome, Guadalajara type 2: A rare syndrome characterized mainly by retarded fetal growth and permanently flexed finger (camptodactyly).
  • Camptodactyly syndrome, Guadalajara type 3: A rare syndrome characterized mainly by retarded fetal growth and permanently flexed finger (camptodactyly).
  • Camptodactyly syndrome, Guadalajara type III: A rare syndrome characterized mainly by a variety of defects including facial dysmorphism.
  • Camptodactyly, fibrous tissue hyperplasia, and skeletal dysplasia: A rare syndrome characterized by a hand deformity and skeletal abnormalities.
  • Cardiac malformation, cleft lip-palate, microcephaly and digital anomalies: A newly described syndrome characterized by heart malformations, cleft lip/palate, small head and digital anomalies.
  • Carnevale-Hernandez-Castillo syndrome: An extremely rare disorder characterized by missing digits or parts of digits and a thumb that has three bones like a finger instead of the normal two.
  • Carpal spasm: Also known as carpopedal spam. It is the spasm of the hands or feet.
  • Carpenter syndrome: A rare genetic disorder characterized by premature closing of skull bones, craniofacial abnormalities, heart defects, growth retardation and other disorders.
  • Carpopedal spasm: Spasm of hand or foot seen in tetany.
  • Cartwright-Nelson-Fryns syndrome: A rare syndrome characterized by mental and physical retardation as well as nail and digital abnormalities.
  • Cataract, alopecia, sclerodactyly: A rare disorder characterized by cataracts, lack of hair and skin changes in the hands and feet.
  • Cephalopolysyndactyly: A rare genetic disorder characterized by premature closing of skull bones and craniofacial abnormalities, finger and toe abnormalities. The type and severity of symptoms is variable with many cases remaining undiagnosed because their condition is relatively mild and doesn't cause many problems.
  • Cerebellar ataxia -- areflexia -- pes cavus -- optic atrophy -- sensorineural hearing loss: A rare syndrome characterized mainly by ataxia, absent reflexes, high foot arch (pes cavus), progressive optic nerve degeneration and hearing impairment. The ataxic symptoms tended to occur early in life after an illness involving fevers. The ataxia then tends to come and go but then persists into adulthood. The severity of symptoms is variable.
  • Cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss: A rare syndrome characterized mainly by ataxia, absent reflexes, high foot arch (pes cavus), progressive optic nerve degeneration and hearing impairment. The ataxic symptoms tended to occur early in life after an illness involving fevers. The ataxia then tends to come and go but then persists into adulthood.
  • Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome: A rare disorder characterized by abnormal brain development, neurological problems, scaly skin and thickened skin on the palms and soles.
  • Charlie M syndrome: A rare birth disorder characterized by facial abnormalities and malformed or missing parts of the ends of the arms and legs.
  • Chemke-Oliver-Mallek syndrome: A very rare syndrome characterized mainly by eye and finger and toe abnormalities.
  • Chilblain: Skin inflammation usually in cold weather
  • Circulatory disorder: Disease affecting circulation of blood
  • Cleft palate -- cardiac defect -- genital anomalies -- ectrodactyly: A very rare syndrome characterized by variable symptoms including cleft palate, heart defects, genital anomalies and hand and foot malformations.
  • Clubfoot: Congenital foot birth deformity turning the foot inward
  • Coffin-Siris Syndrome: A rare genetic disorder characterized by underdeveloped or absent fifth finger and toenails and coarse facial features.
  • Collins-Sakati syndrome: A very rare syndrome characterized mainly by a short, broad toe and a large head.
  • Conditions associated with nail abnormalities: Nail abnormalities are problems with the color, shape, texture, or thickness of the fingernails or toenails.
  • Congenital ichthyosiform erythroderma: A rare inherited skin disease characterized by chronic redness and the development of thick scaly skin on palms and soles.
  • Corneodermatoosseous syndrome: A very rare syndrome characterized mainly by thick, scaly skin on the palms and soles, corneal changes and dental problems.
  • Coronal synostosis, syndactyly and jejunal atresia: A very rare syndrome characterized mainly by webbed toes, blocked small intestine and premature fusion of certain skull bones (coronal).
  • Cortes-Lacassie syndrome: A rare syndrome characterized by nail, hair and teeth abnormalities, malformed hands and feet and seizures. The disorder has only been reported in one cause which resulted in death at 31 months
  • Cousin Walbrau Cegarra Syndrome:
  • Craniodigital syndrome -- mental retardation: A very rare syndrome characterized by webbed fingers and toes, mental retardation and skull and facial anomalies.
  • Craniofacial conodysplasia: A rare disorder characterized by neurological symptoms and abnormally-shaped bones in the hands and feet. The neurological symptoms are caused by a buildup of fluid inside the skull as well as compression of the spinal cord at the neck-skull junction.
  • Craniosynostosis Fontaine type: A very rare disorder characterized primarily by the premature fusion of skull bones, hand, foot and stomach anomalies and a brain malformation (bilateral periventricular nodular heterotopia).
  • Craniosynostosis Maroteaux Fonfria type: A rare disorder which is similar to a condition called Apert syndrome but also involves extra fingers and toes. Apert syndrome is characterized by abnormalities in the appearance of the face and head as well as finger and toe abnormalities. The bones of the skull fuse together too early which prevents it from growing normally
  • Crossed polysyndactyly: A rare malformation characterized by an extra finger beside the small finger, duplication of the big toe and webbing of various fingers and toes.
  • Cryptomicrotia -- brachydactyly syndrome: A very rare syndrome characterized mainly by ear malformations and short fingers and toes.
  • Cushing's symphalangism: A rare syndrome characterized by deafness and the fusion of joints in the middle of fingers and toes as well as fusion of hand and foot bones.
  • Czeizel-Losonci syndrome: A very rare syndrome characterized by missing fingers, ureter abnormalities, webbed fingers and toes and abnormal spinal development.
  • Dahlberg syndrome: A rare condition characterized by hypoparathyroidism, nephropathy, congenital lymphedema, mitral valve prolapse and short end bones in fingers and toes.
  • Dandy-Walker malformation postaxial polydactyly: A very rare syndrome where the Dandy-Walker malformation is associated with extra fingers and toes.
  • Daneman Davy Mancer syndrome: A very rare syndrome characterized mainly by kidney, thyroid and finger and toe abnormalities.
  • Dauwerse-Peters syndrome: A rare disorder characterized by short stature, unusual facial appearance, very short fingers and short toes as well as other skeletal anomalies.
  • Deafness -- enamel hypoplasia -- nail defects: A very rare syndrome characterized mainly by deafness, tooth enamel abnormalities and nail defects.
  • Deafness -- hypospadias -- metacarpal and metatarsal synostosis: A very rare syndrome characterized mainly by deafness, penis abnormalities and bone anomalies in the foot and hands.
  • Deafness -- onychodystrophy -- osteodystrophy -- mental retardation: A very rare inherited disorder involving deafness (D), onychodystrophy (O - nail malformation), osteodystrophy (O - bone malformation) and mental retardation (R).
  • Deafness onychodystrophy dominant form: A rare dominantly inherited disorder characterized by deafness from birth, deformed nails and
  • Deafness symphalangism: A rare genetic disorder characterized by deafness, distinctive facial features and fusion of various bones in the fingers, toes and upper arms. Joint ankylosis starts in early childhood and is progressive.
  • Deafness, congenital onychodystrophy, recessive form: A very rare inherited disorder involving deafness (D), onychodystrophy (O - nail malformation), osteodystrophy (O - bone malformation) and mental retardation (R).
  • Dermatopathia pigmentosa reticularis: A very rare syndrome characterized mainly by increased skin pigmentation, thickened skin on palms and soles and reduced sweating.
  • Diabetes: Failing or reduced ability of the body to handle sugars.
  • Diabetes like foot weakness: Weakness due to lesions in the muscles of the feet.
  • Diabetic neuropathy: Nerve damage from diabetes affecting any body part; most commonly feet.
  • Diaphanospondylodysostosis: A rare disorder characterized by bone formation anomalies including a lack of bone formation in the spine during the fetal stage as well as kidney problems.
  • Difficulty walking: Where ones has a problem with mobilizing on ones feet
  • Diffuse palmoplantar keratoderma -- acrocyanosis: A rare disorder characterized mainly by thickening of the skin on the palms and soles as well as a bluish discoloration of the hands and feet.
  • Diffuse palmoplantar keratoderma, Bothnian type: Thickened skin on palms and soles.
  • Diffuse palmoplantar keratoderma, Norrbotten dominant type: A rare disorder characterized by thickening of the skin on the palms and soles which is associated with frequent fungal infections.
  • Digital arthropathy-brachydactyly, familial: A rare familial disorder characterized by progressive joint disease causing shortening of the end two bones of the fingers and toes. The hands tend to be more affected than the feet.
  • Digitorenocerebral syndrome: A very rare syndrome characterized by numerous abnormalities involving the brain, kidneys, fingers, toes, nails and face as well as mental retardation and vision impairment.
  • Distal lateral subungual onychomycosis: A fungal infection of the nail which tends to involve start under the nail where it separates from the nail bed. This is the most common form of onychomycosis and the toenails tend to be affected more than the fingernails.
  • Double nails on the fifth toe: A very rare abnormality where an infant is born with two toenails on the fifth toe. One toenail is usually normal with the other one being smaller and located near the first toenail or even underneath the toe.
  • Duplication of leg mirror foot: A birth malformation characterized by the absence of the tibia and partial duplication of the foot. The partial duplication of the foot means that one foot can have as many as nine toes. Usually only one foot is affected.
  • Dupuytren subungual exostosis: A benign form of slow-growing tumor that develops on the surface of the bones under the nails. The cause of the condition is unknown and it tends to occur in children and young adults. The big toe is the most common digit affected.
  • Dwarfism, short-limb -- absent fibulas -- very short digits: A very rare disorder characterized by short limbs, missing calf bones and very short fingers and toes due to under developed or missing bones.
  • Dyshidrotic dermatitis: A skin disorder (eczema) that affects the soles of the feet, the palms of the hands and the sides of the fingers. There is no known cause but contributing factors include stress, hot or cold weather, pre-existing atopic condition, metal implants, smoking, and aspirin and oral contraceptive use.
  • Dysostosis peripheral: A rare condition characterized by malformed bones in the hands and feet. The severity of the malformation is variable.
  • Dysplasia epiphysealis hemimelica: A condition characterized by overgrowth of the epiphyseal cartilage on one of the hand or foot bones and occasionally on other bones.
  • ECP syndrome: A rare malformation syndrome characterized by a cleft palate and missing fingers.
  • EEC syndrome: A rare genetic disorder characterized by absence of fingers and toes, ectodermal dysplasia and cleft lip or cleft palate.
  • EEC syndrome without cleft lip/palate: A rare syndrome characterized mainly by hand, foot deformities as well as hair, skin, nail and tooth abnormalities (ectodermal dysplasia).
  • Ectodermal dysplasia -- alopecia -- preaxial polydactyly: A rare syndrome characterized by facial abnormalities, extra toes and sparse or absent hair.
  • Ectodermal dysplasia trichoodontoonychial type: A rare syndrome characterized by nail, tooth and hair abnormalities.
  • Ectodermal dysplasia, 'pure' hair-nail type: A rare syndrome characterized mainly by greatly reduced hair on the scalp, eyelashes and eyebrows as well as abnormal nails.
  • Ectodermal dysplasia, Margarita type: A rare genetic disorder characterized by mental retardation, webbed digits, cleft lip, cleft palate, sparse hair, reduced sweating and teeth abnormalities. Progressive loss of scalp hair usually results in baldness by adulthood.
  • Ectodermal dysplasia/ skin fragility syndrome: An extremely rare syndrome characterized by fragile skin which blisters and peels, abnormal nails and thickened skin on palms and soles. Skin blistering and peeling starts at birth.
  • Ectrodactyly -- Ectodermal Dysplasia -- Cleft Lip/Palate Syndrome, Type 1: EEC (Ectrodactyly, ectodermal dysplasia, cleft lip/palate) is a rare inherited condition characterized by split hand and foot deformities of variable severity, cleft lip or palate and teeth and hair anomalies. There are two main types of EEC which differ in the origin of the genetic defect. Type 1 is caused by a defect on chromosome 7q11. The severity and type of symptoms and deformities is highly variable.
  • Ectrodactyly -- Ectodermal Dysplasia -- Cleft Lip/Palate Syndrome, Type 3: EEC (Ectrodactyly, ectodermal dysplasia, cleft lip/palate) is a rare inherited condition characterized by split hand and foot deformities of variable severity, cleft lip or palate and teeth and hair anomalies. There are two main types of EEC which differ in the origin of the genetic defect. Type 3 is caused by a defect on chromosome 3q27. The severity and type of symptoms and deformities is highly variable.
  • Ectrodactyly -- polydactyly: A rare syndrome characterized primarily by extra digits, missing digits, cleft foot or cleft hand.
  • Ectrodactyly and Ectodermal Dysplasia without Cleft Lip/Palate: A rare inherited syndrome characterized by the EEC syndrome without and oral clefting. The EED syndrome involves a hand deformity (ectrodactyly) and abnormalities of the hair, eyes and skin. The severity of the deformities is variable.
  • Edward Syndrome: A rare genetic chromosomal syndrome where the child has an extra third copy of chromosome 18. Most fetuses are aborted before term, but a live birth with this condition occurs with a frequency around 1-in-3000. Duplication 18 syndrome is more severe than the more common Down syndrome. Duplication 18 syndrome causes mental retardation and numerous physical defects that often cause an early infant death. The condition has variable severity depending on how many of the body's cells have the extra chromosome and how much of the extra chromosome is duplicated. In severe forms all cells have an extra copy of the complete chromosome 18 whereas milder forms may have only some cells having the extra chromosome. Other mild forms may have an extra copy of only part of chromosome 18 in some or all of the body cells.
  • Edwards Syndrome: A rare inherited genetic disorder where a portion of chromosome 18 is duplicated. Most affected individuals die during the fetal stage and surviving infants have serious defects and tend to live for only a short while.
  • Edwards-Gale Syndrome: A rare hand and foot abnormality where the fingers and toes are unusually short and the first part of the fingers or toes are held in a fixed contracted position.
  • Elattoproteus syndrome: A rare disorder involving a lack of growth of various parts of the body such as the skin and the fatty layer under the skin.
  • Elejalde syndrome: A rare congenital syndrome characterized excessive fetal growth, skull abnormalities, extra fingers or toes and other abnormalities.
  • Emery-Nelson syndrome: A rare condition characterized by a flat face and hand and foot abnormalities.
  • Endonyx onychomycosis: A fungal infection of the nail that tends to predominantly cause a white discoloration of the nail. There tends to be no damage to the nail apart from the discoloration and there is no damage to the nail bed.
  • Engelhard-Yatziv syndrome: A rare syndrome characterized mainly by droopy eyelids, small head and finger and toe abnormalities.
  • Epidermolytic palmoplantar keratoderma Vorner type: A rare skin disorder characterized by thickening of the skin on the palms and soles as well as degeneration of some layers of the skin tissue.
  • Erythema elevatum diutinum: A rare chronic skin disorder characterized by skin nodules and plaques near joints and on the back of the hands and feet.
  • Erythermalgia: A disorder involving periodic burning, redness and increased temperature in the extremities. Exercise, standing for long periods and heat can trigger an episode.
  • Erythrokeratodermia symmetrica progressiva: A rare inherited skin disease with characteristic skin lesions usually found on hands and feet but can be found on other parts of the body.
  • Erythromelalgia: A rare disorder characterized by periods of burning pain, redness and warmth in the feet and hands.
  • Esophageal Atresia, Coloboma, Clubfoot: A rare condition characterized by the association of eye coloboma, clubfoot and atresia of the esophagus.
  • Exostoses -- anetodermia -- brachydactyly type E: A rare syndrome characterized mainly by bone growths, a skin disorder and short foot bones.
  • Eye defects -- arachnodactyly -- cardiopathy: A rare syndrome characterized mainly by eye defects, long, thin fingers and heart disease.
  • Eyebrow Duplication -- Stretchable Skin -- Syndactyly: A rare syndrome characterized by partially duplicated eyebrows, abnormally stretchy skin and webbed digits.
  • Eyebrows duplication of, with stretchable skin and syndactyly: A rare syndrome characterized mainly by duplication of some of the eyebrow, increased skin elasticity and webbed fingers and toes.
  • Eyebrows duplication syndactyly: A rare syndrome characterized mainly by duplication of some of the eyebrow, webbed fingers and toes and occasionally increased skin elasticity and other variable symptoms.
  • FACES syndrome: A rare syndrome characterized mainly by short stature, webbed fingers and toes and skeletal abnormalities.
  • Faciodigitogenital syndrome, recessive form: A rare syndrome characterized by facial, digital and genital abnormalities.
  • Familial opposable triphalangeal thumbs duplication: A rare birth malformation where the thumb has three bones instead of the normal two which gives it a fingerlike appearance. An extra toe is also present.
  • Favre-Chaix angiodermatitis: Skin and blood vessel changes that occur in the feet due to chronically poor blood supply. The size of the lesion may vary from tiny to covering a large part of the foot.
  • Filippi Syndrome: A very rare disorder involving finger and toe abnormalities, a small head, characteristic face and physical and mental retardation. The number of digits involved and extent of webbing between digits is variable as are many of the other features.
  • Fingerprints absence -- syndactyly -- milia: A very rare syndrome characterized mainly by the absence of fingerprints, webbed toes and milia.
  • Fischer Syndrome: A rare condition characterized by unusual facial appearance, thickened skin on palms and soles, physical and mental delay and various other anomalies.
  • Fitzsimmons-McLachlan-Gilbert syndrome: A very rare syndrome characterized mainly by mental retardation paraplegia and thickened coarse skin on palms and soles.
  • Flat feet: Lowered arch of the foot
  • Focal Familial Palmoplantar Keratoderma with Punctate Hyperkeratosis of the Palmar Creases: A rare condition characterized by the development of small bumps of thickened skin along the creases of the palms and fingers and sometimes the soles of the feet.
  • Foot fracture: A fracture of one or several bones of the foot
  • Foot injury: Any injury to the foot
  • Foot pain: Pain affecting one or both feet
  • Foot sprain: Damage to ligaments in the foot.
  • Foot swelling: Oedema of the foot.
  • Foot ulcer: A skin ulcer that is located on the foot
  • Footdrop: A condition which is characterized by the dropping of the foot due to a paralysis of the anterior muscles of the leg
  • Fraser-Jequier-Chen syndrome: A very rare disorder characterized by a cleft epiglottis and larynx, extra fingers and toes and kidney, pancreatic and bone abnormalities. The internal organs are also located on the opposite side of the body to normal (situs inversus totalis).
  • Fraser-like syndrome: A very rare syndrome characterized by fused eyelids, airway anomalies, cysts in the ovaries and finger and toe abnormalities.
  • Freiberg disease: A condition where progressive degeneration of the head of a toe bone (usually the second toe) results in foot pain.
  • Frias syndrome: A rare syndrome characterized mainly by short stature, short fingers and toes and facial anomalies.
  • Fungal nail infections: Fungal conditions of the toenail or fingernail
  • Ganglion cyst: Cyst affecting the sheath of tendons
  • Golden-Lakin syndrome: A rare syndrome characterized by a webbed neck, sunken chest, curved spine and various other abnormalities.
  • Gordon Syndrome: A genetic musculoskeletal disorder characterized mainly by camptodactyly, cleft palate and club foot. The type and severity of symptoms is variable.
  • Gorlin-Sedano syndrome: A rare disorder characterized by short hand and foot bones, short thumbs and collarbones and impacted teeth.
  • Gout: Painful joints, most commonly the big toe.
  • Grebe Syndrome: A rare genetic disorder characterized by very short limbs and extra fingers and toes.
  • Green nail syndrome: A nail infection caused by Pseudomonas aeruginosa and sometimes Aspergillus. The infection tends to occur in women who spend a lot of time with their hands in soapy water or detergents. The nails develop varying patterns of greenish discoloration.
  • Greig Cephalopolysyndactyly Syndrome: A rare genetic disorder characterized by premature closing of skull bones and craniofacial abnormalities, finger and toe abnormalities.
  • Growth deficiency brachydactyly unusual facies: A rare syndrome characterized mainly by short stature, short fingers and toes and facial anomalies.
  • Hairy palms and soles: A rare inherited condition characterized by patches of hair on the palms and soles. The patches of skin associated with the hair has hair follicles and is different to the normal skin on palms and soles.
  • Hajdu-Cheney Syndrome: A rare genetic disorder characterized by early tooth loss, relaxed joints, small stature and bone abnormalities.
  • Hallux Rigidus: A stiff big toe and loss of it's mobility due to degenerative arthritis at the base joint of the big toe. It usually occurs between the ages of 30 and 60 years.
  • Hallux limitus: The early stages of toe stiffness due to degenerative arthritis of the base of the big toe. As the condition progresses and the toe becomes totally immobile and the condition is then called hallux rigidus.
  • Hallux valgus: A condition which is characterized by the prominence of the inner aspect of the first metatarsal head with bursal formation.
  • Hammer toe: Toe bent into hammer-like shape
  • Hand, Foot, & Mouth Disease: Common contagious viral infant or child condition
  • Hand-Foot-Mouth Syndrome: An infectious viral disease caused by the coxsackievirus A. The disease is characterized by the development of blisters in the mouth and on hands and feet. The disease is spread by contact with body fluids from an infected person and the incubation period is 3 - 7 days. The infection is most common in children under the age of ten but can occur in teenagers and sometimes in adults.
  • Hand-foot-uterus syndrome: A rare genetic condition characterized by hand, foot and uterus abnormalities.
  • Hanhart Syndrome: An autosomal recessive disorder due to a deficiency in the body of the tyrosine amino transferase enzyme.
  • Hanhart syndrome type I: A rare genetic disorder characterized by retarded growth, impaired libido, distinctive facial features, delayed puberty and excess fatty deposits in breast and abdominal area.
  • Hanhart syndrome type II: A rare genetic disorder characterized by retarded growth, distinctive facial features, delayed puberty, excess fatty deposits in breast and abdominal area, small jaw , small tongue, hand and foot deformities and missing teeth.
  • Hanhart syndrome type III: A rare genetic disorder characterized by hand and foot deformities, small jaw, small tongue, mental retardation and a cleft palate.
  • Hanhart syndrome type IV: A rare disorder where a genetic error of amino acid metabolism results in thickened skin on palms and soles, skin lumps, mental retardation and finger, toe, eye, hair and teeth abnormalities.
  • Harrod Doman Keele syndrome: A very rare syndrome characterized mainly by skull, facial, genital, finger and toe abnormalities.
  • Heberden's nodes: A condition which is characterized by small hard nodules usually in the interphalangeal joints
  • Hecht syndrome: A rare genetic disorder characterized by the inability to open the mouth due to short muscles as well as hand movement abnormalities also due to shortened muscles.
  • Heel spur: Bony spur on the heel bone
  • Hereditary koilonychia: An inherited anomaly where the nails are flattened or concave-shaped rather than the normal curved shape.
  • Hereditary vascular retinopathie -- Raynaud phenomenon -- migraine: An inherited disorder characterized by a disease of the small retinal blood vessels, migrains and Raynaud's phenomenon.
  • Hirschsprung disease -- polydactyly -- heart disease: A rare disorder characterized by Hirschsprung disease, extra little finger, extra big toe and a heart defect.
  • Hirschsprung disease type D brachydactyly: A developmental defect of the intestinal tract where the muscles of the intestines are unable to function and move food along the digestive tract. This form of Hirschsprung disease also involves finger and toe abnormalities.
  • Horn-Kolb syndrome: A congenital malformation involving symmetrically absent hands and feet. Little lumps on the ends of the limbs may be all that remains of the fingers and toes.
  • Howard-Young syndrome: A very rare syndrome characterized mainly by a small head, facial cleft and an extra big toe.
  • Hunter-McAlpine syndrome: A very rare dominantly inherited syndrome characterized mainly by premature fusion of skull bones, mental retardation, small mouth, short stature and finger and toe anomalies.
  • Hydrops ectrodactyly syndactyly: A very rare disorder characterized mainly be webbed fingers and toes, hand defect and hydrops (abnormal accumulation of fluid in the fetus).
  • Hyperkeratosis lenticularis perstans: A rare skin disorder characterized by reddish-brown papules that tend to occur mainly on the lower legs and top part of the feet.
  • Hyperphalangism -- dysmorphy -- bronchomalacia: A very rare syndrome characterized mainly by finger and toe abnormalities, unusual facial features and narrowed airways.
  • Hyperpigmentation of nails: Increased pigmentation of the nail.
  • Hypertrichosis brachydactyly obesity and mental retardation: A very rare disorder characterized mainly by excessive hair growth, short digits, obesity and mental retardation
  • Hypodontia -- nail dysgenesis: A syndrome that is characterized by the occurrence of nail dysplasia and tooth abnormalities. Primary teeth are usually normal but some secondary teeth may be missing. The toenails tend to be more affected than the fingernails.
  • Hypodontia dysplasia of nails: A syndrome that is characterised by the occurrence of nail dysplasia and tooth abnormalities. Primary teeth are usually normal but some secondary teeth may be missing. The toenails tend to be more affected than the fingernails.
  • Hypogonadotropic hypogonadism -- syndactyly: A very rare syndrome characterized mainly by webbed toes and reduced gonad function.
  • Hypokeratosis, palmo-plantar, circumscribed: A condition characterized by a depressed area of skin on the palm or sole due to a thinning of the horny layer of the skin. It is a localized defect in the keratinization of the skin. Usually there is only one lesion and is mostly reported in middle-aged or older women.
  • Hypoplasia of the tibia with polydactyly: A very rare syndrome characterized mainly by an extra little finger and toe as well as an underdeveloped shin bone.
  • Idaho syndrome: A very rare syndrome characterized by a variety of abnormalities including clubfoot, mental retardation, finger abnormalities and a congenital heart defect.
  • Infantile digital fibromatosis: A rare disorder where firm pink nodules develop mainly on the fingers and toes of infants. Often they are present at birth. There is no determined cause but it is considered a harmless condition. Often the lumps disappear on their own and others can be surgically removed but they often recur.
  • Ingrown nails: Inward growth of finger-nails or toe-nails.
  • Ingrown toenail: A condition which is characterized by an aberrant growth of the toenail
  • Inherited Acroosteolysis, phalangeal type: A medical term for the slowly progressive destruction of the distal end of bones in the hands and feet. The condition may be inherited or may be acquired in occupations involving polyvinylcholoride plastic material.
  • Iris coloboma, macrocephaly, agenesis of the corpus callosum, brachydactyly and mental retardation: A rare syndrome characterized mainly by a small head, brain anomaly, short digits, mental retardation and an eye defect.
  • Jackson-Weiss Syndrome: A rare inherited disorder involving bone abnormalities such as fusion of upper foot bones and premature fusion of skull bones which prevents the skull from growing normally. Symptoms can range from mild to severe.
  • Jadassohn-Lewandowsky syndrome: A rare, inherited disorder characterized by thickening of nails, white patches on mouth and anus(leukoplakia) and thickened hard skin on soles and palms.
  • Johnson-Munson syndrome: A rare congenital disorder characterized by missing fingers and toes, abnormal vertebrae and various malformations of the organs.
  • Juberg-Hayward syndrome: A rare hereditary disorder characterized by a growth hormone deficiency as well as mouth and limb abnormalities.
  • Judge-Misch-Wright syndrome: A very rare syndrome characterized mainly by thickened skin on palms and soles as well as around the mouth.
  • Jussieu syndrome: A rare syndrome characterized mainly by the association of a missing tongue with missing fingers or toes. Other malformations are also variably present.
  • Kashin-Bek disease: A disease involving progressive joint degeneration which affects the spine and hands and feet. The condition becomes progressively worse and eventually leads to disability. The condition is most often seen in children who live in the northern parts of China, Siberia and Korea. A possible cause is believed to be eating cereals contaminated with a fungus called Sporotrichella.
  • Kaufman oculocerebrofacial syndrome: A rare syndrome characterized by a small head, narrow face, eye anomalies, severe mental retardation and long thin hands and feet. The disorder is recessively inherited.
  • Keratoderma palmoplantar -- deafness: A very rare syndrome characterized by deafness and a horny superficial growth on the palms and soles.
  • Keratoderma palmoplantar, Norrbotten recessive type: An inherited disorder characterized mainly by thickened skin on the palms and soles. The severity of the thickening can vary but it is generally considered a relatively severe form of palmoplantar keratoderma
  • Keratoderma palmoplantaris transgrediens et progrediens: A rare syndrome characterized mainly by coarse hair and superficial horny growths on the palms and soles. Short fingers and thin nails have also been observed.
  • Keratoderma, Palmoplantar, Diffuse: A group of skin disorders characterized by thickened skin on the palms and soles.
  • Keratosis Palmaris Et Plantaris with Esophageal Cancer: A condition characterized by thickening of the skin on the palms of the hands and soles of the feet as well as an increased risk of developing esophageal cancer which increases with age.
  • Keratosis Palmoplantaris -- Esophageal Carcinoma: A condition characterized by thickening of the skin on the palms of the hands and soles of the feet as well as an increased risk of developing esophageal cancer which increases with age.
  • Keratosis focal -- palmoplantar, gingival: A rare syndrome characterized mainly by thickened skin on the soles and palms in areas that are under the most trauma e.g. weight-bearing part of sole. The gums also have thickened growths.
  • Keratosis palmaris et plantaris -- clinodactyly: A rare disorder characterized by the association of thickened skin on the palms and soles as well curvature of the fifth finger.
  • Keratosis palmoplantar periodontopathy: A very rare inherited condition characterized by dry scaly patches on the skin of the palms and soles, gum and teeth problems and frequent skin infections.
  • Keratosis palmoplantaris -- adenocarcinoma of the colon: A rare disorder characterized by cancer of the secretory lining of the colon as well as thickening of the skin on the palms and soles. The colon cancer tends to grow slowly.
  • Keratosis palmoplantaris -- corneal dystrophy: A rare condition where a deficiency of a liver enzyme (tyrosinase aminotransferase) causes tyrosine levels in the blood to increase and result in eye problems, mental retardation and horny skin lesions which develop on pressure points on the hands and feet.
  • Keratosis palmoplantaris -- esophageal cancer:
  • Keratosis palmoplantaris -- periodontopathia -- onychogryposis: A rare syndrome characterized by gum disease, nail and skin problems and various other anomalies.
  • Keratosis palmoplantaris papulosa: A rare condition involving thickening of the skin on the palms and soles
  • Keratosis palmoplantaris striata: A very rare skin disorder involving streaks of thickened skin along the fingers and palms as well as the bottom of the feet. There are three main subtypes and each is caused by a different genetic defect.
  • Keratosis palmoplantaris striata 1: A very rare skin disorder involving streaks of thickened skin along the fingers and palms as well as the bottom of the feet. Type 1 is caused by a genetic defect located on chromosome 18q12.1-q12.2,12q13.
  • Keratosis palmoplantaris striata 2: A very rare skin disorder involving streaks of thickened skin along the fingers and palms as well as the bottom of the feet. Type 2 is caused by a genetic defect located on chromosome 6.
  • Keratosis palmoplantaris striata 3: A very rare skin disorder involving streaks of thickened skin along the fingers and palms as well as the bottom of the feet. Type 3 is caused by a genetic defect located on chromosome 12q13.
  • Keratosis palmoplantaris with esophageal cancer: A very rare condition involving thickening and hardening of the horny layer of skin on the palms and soles as well as an frequent association with esophageal cancer.
  • Knock knees: Knees that touch
  • Knuckle pads, leukonychia and sensorineural deafness: A very rare syndrome characterized mainly by deafness, knuckle pads and white nails.
  • Kohler disease: A rare disorder where the foot becomes sore, swollen and difficult to walk on due to damage to midfoot bone (navicular bone). The cause is unknown.
  • Kohler syndrome: A rare foot disorder where progressive degeneration of the navicular bone in the foot causes pain and swelling.
  • Krause-Kivlin syndrome: A rare genetic disorder characterized by short limb dwarfism, mental retardation and Peters anomaly.
  • Kurczynski-Casperson syndrome: A very rare syndrome characterized mainly by premature fusion of skull bones, abnormal ears and webbing of the last two toes.
  • Landy-Donnai syndrome: A very rare disorder characterized by a missing fingers and hand bones, webbed fingers, duplicated big toe and hydrops.
  • Laurence-Moon Syndrome: A rare inherited disorder characterized by vision loss, impaired hormone production, mental retardation and spastic paraplegia.
  • Laurence-Prosser-Rocker syndrome: A rare disorder characterized by a congenital heart defect, broad big toes, extra little finger and intestinal dysfunction.
  • Le Marec-Bracq-Picaud syndrome: A very rare syndrome characterized mainly by a large head, short arms and clubfoot.
  • Ledderhose disease: A rare disorder where numerous fibrous nodules develop in the bottom of the foot and eventually affect the tendons in the foot which can cause foot problems.
  • Leg Duplication -- Mirror Foot: A birth malformation characterized by the absence of the tibia and partial duplication of the foot. The partial duplication of the foot means that one foot can have as many as nine toes. Usually only one foot is affected.
  • Leg conditions: Conditions that affect ones leg
  • Leukoencephalopathy -- palmoplantar keratoderma: A very rare inherited disorder characterized mainly by skin problems involving the palms and soles during childhood and neurological problems such as cognitive impairment during adulthood.
  • Leukonychia totalis: A rare nail disorder where the whole of the nail is completely white at birth.
  • Leukonychia totalis -- trichilemmal cysts -- cilliary dystrophy: A very rare syndrome characterized mainly by kidney stones, completely white nails and cysts that form in oil producing areas of skin.
  • Levy-Yeboa Syndrome: A rare inherited syndrome characterized by abnormalities of various bodys systems. Symptoms include low muscle tone, stiff joints, deafness, skin blisters (mainly on hands and feet) and a blank facial expression.
  • Limb conditions: Medical conditions affecting the upper or lower limbs.
  • Limb deficiencies distal micrognathia: A rare genetic disorder characterized by a small jaw, small mouth and defects involving the hands and feet.
  • Limb-mammary syndrome: A rare syndrome characterized by abnormalities of the hand and/or foot as well as absent or underdeveloped mammary glands and nipples. The severity of the deformity is variable. Tooth, nail and sweat gland abnormalities may also be present.
  • Limited cutaneous systemic sclerosis: A rare disorder that primarily affects the skin and blood vessels. It is characterized by calcified skin deposits (C), Raynaud syndrome (R), esophageal dysfunction (E), scleroderma of the fingers and toes(S) and telengiectasia - dilated blood vessels (T).
  • Lower limb conditions: Any medical condition affecting the lower limbs, i.e. the legs, knees, feet, etc..
  • Lundberg I: A rare inherited disorder characterized by damage to the eye and a reduced ability to control movements as well as foot problems.
  • Macrocephaly pigmentation large hands feet: An extremely rare condition characterized mainly by the association of an enlarged head, pigmentation anomalies and large hands and feet.
  • Macrodactyly: A medical term for the considerable enlargement of a finger or toe. The bones and all the soft tissue associated with the digit are also enlarged.
  • Macrodactyly -- Hemihypertrophy -- Connective tissue nevi syndrome: A birth disorder characterized manily by large toes, large head, skin pigmentation anomaly and asymmetrical face and arm.
  • Macrodactyly of the foot: A birth defect where the foot grows larger than normal.
  • Marie-Bamberg syndrome: A rare condition characterized by clubbing of fingers and toes, excessive sweating and development of fibrous tissue around the ends of bones. The condition is a form of hypertrophic osteoarthropathy that occurs secondary to other conditions such as cardiopulmonary disease and certain cancers.
  • Maroteaux-Fonfria syndrome: A rare congenital disorder characterized by extra little fingers and extra big toes as well as the normal features associated with Apert syndrome.
  • Melanoma: Melanoma is the most dangerous type of skin cancer. It is the leading cause of death from skin disease. It involves cells called melanocytes, which produce a skin pigment called melanin. Melanin is responsible for skin and hair color.
  • Meleda Disease: A very rare inherited skin disorder primarily involving dry thick skin patches that develop on the palms of hands and soles of feet. The type and severity of symptoms is variable.
  • Mental mixed retardation -- deafness -- clubbed digits: A rare disorder characterized mainly by mental retardation, deafness and clubbed fingers.
  • Mental retardation -- nasal hypoplasia -- obesity -- genital hypoplasia: A rare disorder characterized mainly by the association of mental retardation with obesity and underdeveloped genitals and nose.
  • Metatarsus adductus: A foot deformity that occurs at birth. The bones in the middle of the foot are bent inwards making the front half of the foot turn inwards. It is most likely caused by the position of the fetus while in the womb. The severity of the condition is variable with some cases resolving on their own whereas others require casts to realign the foot.
  • Microcephaly -- facial clefting -- preaxial polydactyly: A very rare condition characterized by the presence of an abnormally small head, facial clefts and extra digits.
  • Microcephaly -- oculo-digito-esophageal-duodenal syndrome (MODED): A very rare syndrome characterized mainly by a small head and gastrointestinal, eye, finger, and toe abnormalities.
  • Microcephaly syndactyly brachymesophalangy: A very rare syndrome characterized mainly by the association of a small head, syndactyly and short middle bones in digits.
  • Morton's Neuroma: Syndrome of entrapment of a nerve within the inter-digital space between the 3rd and 4th toe, usually seen in middle aged women and due to ill-fitting "fashionable" footwear
  • Movement symptoms: Changes to movement or motor abilities
  • Moynahan syndrome III: A rare syndrome characterized mainly by short stature, defective tooth enamel, clubfoot, skin problems and a variety of other anomalies. Blisters tend to occur during the warmer months of the year.
  • Multiple synostoses syndrome 1: A rare genetic disorder characterized by deafness, distinctive facial features and fusion of various bones in the fingers, toes and upper arms.
  • Mycetoma: Any of a group of infections caused by actinomycetes (bacterial) or a fungus (eumycetoma). It causes a chronic, pus-producing infection under the skin and sometimes involves bone. The infection most often occurs in the feet. The infection is most common in arid and semi-arid parts of the world. Serious cases can require amputation of the bone.
  • Nail avulsion: The separation of the nail from the nail bed
  • Nail conditions: Any condition that affects the nail
  • Nail dysplasia: Nail dystrophy that usually starts in early childhood and involves nail striations and loss of nail luster. The condition affects all of the nails.
  • Nail dysplasia, isolated congenital: A rare genetic disorder characterized by abnormal nail development which is usually evident at birth or soon after.
  • Nail psoriasis: Persons with active psoriasis have psoriatic changes in fingernails and/or toenails. In some instances psoriasis may occur only in the nails and nowhere else on the body. Psoriatic changes in nails range from mild to severe, generally reflecting the extent of psoriatic involvement of the nail plate, nail matrix (tissue from which the nail grows), nail bed (tissue under the nail), and skin at the base of the nail. Damage to the nail bed by the pustular psoriasis can result in loss of the nail.
  • Nasodigitoacoustic syndrome: A rare genetic syndrome characterized by abnormalities of the nose, fingers and toes as well as deafness.
  • Nephrosis -- deafness -- urinary tract -- digital malformation: A very rare syndrome characterized mainly by kidney disease, deafness and abnormalities of the urinary tract, fingers and toes.
  • Nerve conditions: Any condition that affects the nerves
  • Night blindness -- skeletal anomalies -- unusual facies: A very rare syndrome characterized mainly by night blindness, a distinctive face and skeletal abnormalities.
  • OFD syndrome type 8: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps and finger abnormalities.
  • OFD syndrome type Figuera: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps, finger abnormalities and absence of all or part of the fibula.
  • OFD syndrome type IX: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps and finger and retinal abnormalities.
  • Oculo-dento-digital dysplasia dominant: A rare disorder characterized by webbing of some fingers, small corneas, enamel abnormalities and slow-growing, dry hair.
  • Oculodigitoesophagoduodenal syndrome: A very rare syndrome characterized mainly by a small head and gastrointestinal, eye, finger, and toe abnormalities.
  • Odonto onycho dysplasia with alopecia: A very rare syndrome characterized mainly by tooth, nail and hair abnormalities.
  • Odonto-tricho-ungual-digito-palmarn syndrome: A rare syndrome characterized mainly by the presence of teeth at birth, hair loss and hand and foot malformations.
  • Odontomicronychial dysplasia: A very rare syndrome characterized mainly by tooth and nail abnormalities.
  • Odontoonychodermal dysplasia: A very rare syndrome characterized mainly by tooth, nail and skin abnormalities.
  • Oligodactyly -- tetramelic postaxial: A malformation involving missing bones in the little fingers or little toes or the complete absence of one or more little fingers or little toes.
  • Olmsted syndrome: A rare congenital condition characterized by progressive thickening and hardening of skin on palms and soles, alopecia and nail abnormalities.
  • Onchyomycosis: A fungal infection of the nail. The toenails tend to be affected more than the fingernails.
  • Onycho-tricho-dysplasia -- neutropenia: A very rare syndrome characterized mainly by hair and nail abnormalities, neutropenia and psychomotor retardation.
  • Onychodystrophy -- deafness: A very rare inherited disorder involving deafness (D), onychodystrophy (O - nail malformation), osteodystrophy (O - bone malformation) and mental retardation (R).
  • Onychodystrophy and anonychia with type B brachydactyly and ectrodactyly: A rare, dominantly inherited disorder characterized abnormal or absent nails, missing fingers, permanently flexed fingers and a broad, finger-like thumb.
  • Onychogryphosis: A disorder that is characterised by the hypertrophy and excessive curving of the nails
  • Onychonychia -- hypoplastic distal phalanges: A rare disorder characterized by underdeveloped or missing end bones in fingers and toes as well as nail abnormalities ranging from underdeveloped to completely absent.
  • Onychotrichodysplasia and neutropenia: A very rare syndrome characterized mainly by nail, hair and blood abnormalities.
  • Onychotrichodysplasia, chronic neutropenia and mental retardation syndrome: A very rare syndrome characterized mainly by hair and nail abnormalities, neutropenia and mental retardation.
  • Oral Leukoplakia Associated with Tylosis and Esophageal Carcinoma: A condition characterized by thickening of the skin on the palms of the hands and soles of the feet as well as an increased risk of developing esophageal cancer which increases with age.
  • Oral facial digital syndrome: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps and finger abnormalities.
  • Oral facial digital syndrome, type 4: A rare inherited disorder characterized by facial, digital and oral abnormalities. Type IV is differentiated from the other types by the presence of severe shinbone deformity.
  • Oral facial digital syndrome, type IV: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps, finger abnormalities, brain defects and short stature.
  • Orofaciodigital syndrome Thurston type: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps and finger abnormalities.
  • Orofaciodigital syndrome type 10: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps, finger abnormalities and absence of all or part of the fibula.
  • Orofaciodigital syndrome type I:
  • Orofaciodigital syndrome type Thurston type:
  • Orofaciodigital syndrome type1: A rare genetic disorder characterized by variable malformations of the face, digits and inside the mouth. Type 1 is distinguished from the other types of this condition by the presence of polycystic kidneys and a X-linked dominant inheritance.
  • Orofaciodigital syndrome, Gabrielli type: A rare genetic disorder involving oral, facial and digital abnormalities as well as skeletal anomalies and psychomotor delay.
  • Orofaciodigital syndrome, Shashi type: A rare genetic disorder involving oral, facial and digital abnormalities as well as the absence of the pituitary gland.
  • Orofaciodigital syndrome, type 3: A rare genetic disorder characterized by oral frenula, oral clefts, underdeveloped nose flaps and finger, teeth and eye abnormalities.
  • Osler's nodes: A condition characterized by a small raised and tender cutaneous lesion that is characteristic of subacute bacterial endocarditis
  • Osteoglophonic dwarfism: A form of dwarfism characterized by premature fusion of skull bones, short limbs and digits, facial abnormalities and bone development anomalies.
  • Otoonychoperoneal syndrome: A very rare syndrome characterized mainly by underdeveloped ears and nails, shoulder anomalies and straight collarbones.
  • Pachyonychia congenita recessive: A rare, recessively inherited disorder where the nails is white and the skin is blistered.
  • Pachyonychia congenital syndrome type I: A rare genetic ectodermal disorder characterized by thick nails, thick skin on palms and soles and white patches on tongue and inside of cheek.
  • Pachyonychia congenital syndrome type II: A rare genetic ectodermal disorder characterized by thick nails.
  • Pallister-Hall Syndrome: A rare genetic disorder characterized by hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and polydactyly.
  • Pallister-Ulnar mammary syndrome: A rare genetic condition characterized by extra or missing digits, breast and dental abnormalities.
  • Palmoplantar Keratoderma: A rare group of disorders where the skin of the palms and soles is thicker than normal. The thickening may occur in small localized areas of the palms and soles or it may occur over the whole surface.
  • Palmoplantar Psoriasis: Psoriasis is a chronic skin condition characterized by scaling and inflammation of the skin which can occur on virtually any part of the body. Palmoplantar psoriasis refers to psoriasis that develops on the palms of the hands and soles of the feet.
  • Palmoplantar keratoderma -- XX sex reversal -- predisposition to squamous cell carcinoma: A rare syndrome characterized by thickened skin on palms and soles, sex reversal (the male has two X chromosomes instead of an X and a Y) and a tendency for developing skin cancers.
  • Palmoplantar keratoderma -- amyotrophy: A rare disorder characterized by the association of thickened skin on the palms and soles with muscle wasting.
  • Palmoplantar keratoderma punctate, hereditary: An inherited disorder characterized by numerous tiny bumps of thickened skin on the palms and soles. The skin develops numerous hyperkeratototic papules which are usually 1-2 mm in size.
  • Palmoplantar porokeratosis of Mantoux: A rare skin disorder where the skin on the palms and soles develop spiny hard lumps. As the bumps disappear, they leave temporary depressions in the skin.
  • Palmoplantar pustular psoriasis: Pustular psoriasis is a form of psoriasis characterized by pustules rather the skin bumps. There are various subtypes of the disorder: generalized, annular, palmoplantar or juvenile. In palmoplantar pustulosis, the pustules only occur on the hands and feet. The skin under and around the pustules is red. The blisters tend to occur in repeated waves and may occur over a period of days or weeks.
  • Paronychia: Skin infection of a nail
  • Patel-Bixler syndrome: A rare disorder characterized by the association of abnormal thickening of skin on palms and soles, nail abnormalities and alopecia.
  • Pectus excavatum macrocephaly dysplastic nails: A rare syndrome characterized mainly by a sunken chest, large head and abnormal nails.
  • Peeling skin syndrome, acral type: A rare inherited syndrome characterized mainly by spontaneously peeling skin on the back of the hands and feet. Heat, humidity and friction can make symptoms worse.
  • Petit-Fryns syndrome: A very rare syndrome characterized mainly by mental retardation, short stature and degeneration or loss of calcium in bones of the hands and feet.
  • Pfeiffer Syndrome Type I: A rare genetic disorder where some of the skull bones fuse too early which affects the size and shape of the skull and face. Thumb and toe abnormalities are also present. There are three types of Pfeiffer syndrome with varying degrees of severity. Type I is the mildest of the three Pfeiffer Syndrome subtypes.
  • Pfeiffer Syndrome Type II: A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include craniofacial and cardiovascular malformations with death often occurring early.
  • Pfeiffer Syndrome Type III:
  • Pfeiffer syndrome: A rare genetic disorder where some of the skull bones fuse too early which affects the size and shape of the skull and face. Thumb and toe abnormalities are also present. There are three types of Pfeiffer syndrome with varying degrees of severity.
  • Pfeiffer syndrome Type 1: A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include craniofacial, hand and feet abnormalities.
  • Pfeiffer syndrome Type 2: A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include craniofacial and cardiovascular malformations with death often occurring early.
  • Pfeiffer syndrome Type 3: A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include craniofacial abnormalities, cardiovascular malformations and early death is common.
  • Pierre Robin sequence -- congenital heart defect -- talipes: A very rare syndrome characterized mainly by an abnormal foot position (talipes), congenital heart defect small jaw, cleft soft palate and a tongue abnormality (glossoptosis).
  • Pigmented purpuric eruption: A disorder involving blood capillary inflammation associated with excess pigmentation. The condition progresses slowly and tends to affect the lower legs and feet.
  • Pili torti -- onychodysplasia: A very rare syndrome characterized mainly by abnormal nails and fragile twisted hair shafts. The condition has been reported in only one family.
  • Piussan-Lenaert-Mathieu syndrome: A rare disorder characterized by mental retardation, a stiff thumb and shortness or absence of middle bones of fingers and toes (brachydactyly type A1).
  • Plantar Fasciitis: Inflammation of fascia - plantar aspect (bottom) of foot.
  • Podagra: A condition which is characterized by a gout like pain in the toe
  • Polydactyly: A rare deformity where the hands and/or feet have extra digits.
  • Polydactyly alopecia seborrheic dermatitis: A very rare disorder characterized by the association of extra digits, alopecia and seborrheic dermatitis.
  • Polydactyly cleft lip palate psychomotor retardation: A very rare syndrome described in a small inbred group of families and characterized by bifid toes, extra big fingers, cleft lip or palate and psychomotor retardation. There were various other symptoms that were variably present.
  • Polydactyly postaxial: An extra finger or toe next to the fifth (littlest) finger or toe.
  • Polydactyly preaxial: A medical term for a hand defect where the thumb is partially or completely duplicated. The anomaly can range from a simple broadening of the end thumb bone with a division in the bone tip to a completely duplicated thumb which gives risk to the four subtypes of the anomaly.
  • Polydactyly preaxial type 1: A rare hand deformity involving duplication of one or more bones of the thumb. The duplication may simply involve a part of the end bone in the thumb which gives it a broad appearance or it may involve duplication of the whole thumb.
  • Polydactyly, preaxial IV: A hand and foot malformation involving extra preaxial digits and webbing of digits.
  • Polysyndactyly -- cardiac malformation: A very rare syndrome characterized mainly by an extra toe, webbed fingers and heart malformations.
  • Polysyndactyly orofacial anomalies: A very rare syndrome characterized by the association of webbed digits and oral and facial anomalies. Various other abnormalities may also be present.
  • Polysyndactyly overgrowth syndrome: A very rare syndrome reported in one infant and characterized by the association of multiple webbed digits with an overly large body size.
  • Polysyndactyly type Haas: A malformation where all the fingers are webbed and there is an extra digit. The webbing did not involve any bone fusion. The feet may have variable degrees of webbing and an extra toe may be present.
  • Popliteal pterygium syndrome, lethal type: A rare lethal condition characterized by webbing of skin as well as various other physical and mental abnormalities.
  • Porokeratosis plantaris, palmaris, et disseminata: A very rare disorder involving progressive skin thickening that starts with the palms and soles.
  • Porokeratosis punctata palmaris et plantaris: A rare skin disorder where the skin on the palms and soles develop spiny hard lumps.
  • Pott gangrene: Tissue death that usually occurs in the extremities of elderly people as a result of arterial blockages. The toes are most commonly affected.
  • Powell-Venencie-Gordon syndrome: A very rare syndrome characterized mainly by thickened skin on the palms and soles as well as spastic paralysis.
  • Pratesi syndrome: Cramping and coldness in the feet. It is most common in middle-aged males.
  • Proximal subungual onychomycosis: A fungal infection of the nail which tends to start at the nail fold and affects new nail growth. The infection starts on the top of the nail and then spreads deeper into the nail. This form of onychomycosis tends to occur primarily in AIDS patients.
  • Pseudoainhum: The development of constricting bands of tissue that can result in autoamputation of the part of the limb involved (usually a digit). The disorder may be inherited or acquired.
  • Pterygium colli -- mental retardation -- digital anomalies: A very rare syndrome characterized mainly by mental retardation, webbed neck and finger abnormalities.
  • Pterygium, Popliteal, lethal type: A rare lethal condition characterized by webbing of skin as well as various other physical and mental abnormalities.
  • Punctate acrokeratoderma -- freckle-like pigmentation: A rare skin disorder involving freckle-like pigmented spots on the back of the hands and feet as well as horny skin areas on the hands and feet.
  • Putti-Chavany syndrome: Irritation of one of the sciatic nerves which causes back and foot pain followed by reduced pain and paralysis and sensory abnormalities in the foot.
  • Radial defect -- Robin sequence: A very rare syndrome characterized mainly by abnormal forearm bone, club foot, finger and toe abnormalities and a cleft palate.
  • Rasmussen-Johnsen-Thomsen syndrome: A very rare syndrome characterized mainly by the lack of an ear canal opening as well as foot deformities.
  • Raynaud's phenomenon: Blood vessel constriction attacks affecting fingers and/or toes.
  • Renon-Delille syndrome: A rare syndrome characterized by reduced function of the thyroid and ovaries and enlarged hands and feet.
  • Richieri-Costa Pereira syndrome: A rare syndrome characterized mainly by the association of short stature, Pierre Robin sequence, cleft mandible, hand anomalies and clubfoot.
  • Richieri-Costa-Silveira-Pereira syndrome: A very rare syndrome characterized mainly by short stature, hand anomaly, clubfoot a cleft palate and various other abnormalities.
  • Rigid mask-like face -- deafness -- polydactyly: A very rare syndrome characterized mainly by deafness, extra digits and a rigid, mask-like face.
  • Robinow-like syndrome: A very rare syndrome characterized mainly by growth problems before and after birth as well as genital and head anomalies.
  • Robinson-Miller-Bensimon syndrome: A very rare syndrome characterized by deafness, malformed nails and other abnormalities.
  • Rolled and spiral hairs -- palmoplantar keratoderma: A rare syndrome characterized by the association of thickened skin on the palms and soles and rolled spiral hairs on the abdomen, hands and feet.
  • Rubinstein-Taybi Syndrome: A rare congenital disorder characterized by very small stature, broad thumbs and toes, slanted palpebral fissures and hypoplastic maxilla.
  • Rubinstein-Taybi like syndrome: A condition characterized by numerous congenital abnormalities including small head, unusual facial features, short stature, broad thumb and big toe and mental retardation.
  • Rudiger syndrome: A rare syndrome characterized by various abnormalities of the feet, hands, face and urogenital system as well as severely retarded growth. Death occurred during early infancy in the recorded cases.
  • Ruptured achilles tendon: Rupture (break) in the achilles tendon
  • Ruvalcaba-Myhre-Smith Syndrome: A syndrome which is characterized by an abnormal shortness of the metacarpal or metatarsal bones and mental and physical retardation.
  • Saethre-Chotzen Syndrome: A rare genetic disorder characterized by premature joining of certain skull bones during development which has an impact on the shape of the head and face. Features include brachycephaly, ear deformities as well as craniofacial, finger and bone abnormalities.
  • Sakati syndrome: A rare genetic condition characterized by head and digital anomalies as well as other abnormalities.
  • Sallis-Beighton syndrome: A rare inherited syndrome characterized mainly by hand and foot abnormalities.
  • Sandrow syndrome: A disorder characterized mainly by hand and foot defects as well as nose abnormalities which affects the ability to breath.
  • Scalp defects -- postaxial polydactyly: A very rare syndrome characterized mainly by scalp defects and extra fingers and toes.
  • Scapuloperoneal Syndrome: A rare inherited condition characterized by progressive muscle wasting and weakness which involves mainly the shoulder and ankle muscles. Facial muscles may develop mild symptoms in later stages of the disorder. Subtypes of the condition may be caused by muscle or nerve disease.
  • Schafer syndrome: A disorder characterized mainly by thickened skin on the palms and soles, white patches in mouth, mental and growth retardation and hair, nail and eye abnormalities.
  • Scholte syndrome: A very rare syndrome characterized mainly by premature balding, dislocated kneecap, hypogonadism and small hands and feet.
  • Schopf-Schulz-Passarge syndrome: A rare syndrome characterized by thickened skin on palms and soles, missing teeth, sparse hair and eyelid cysts.
  • Sclerodactyly: The localisation of scleroderma on the digits
  • Sclerotylosis: A rare inherited disorder characterized by a skin disorder (atrophic skin fibrosis and keratoderma of the palms and soles), underdeveloped nails and bowel cancer.
  • Scott syndrome: A very rare inherited syndrome characterized by head and digital abnormalities as well as mental retardation.
  • Seckel-like syndrome, type Buebel: A rare syndrome characterized by dwarfism and other abnormalities characteristic of Seckel syndrome as well as hand and foot anomalies.
  • Septooptic dysplasia -- digital anomalies: A very rare syndrome characterized mainly by finger and toe abnormalities as well as abnormal development of the optic nerve and pituitary gland. Antenatal exposure to sedatives may be a factor in the cause of the disorder.
  • Severe mental retardation and absent nails of hallux and pollex: A very rare syndrome characterized by the association of severe mental retardation and missing nails on the thumbs and big toes.
  • Shell nail syndrome: A syndrome characterized by deterioration of the nail beds, clubbed fingers, inflammation around the bone and bronchiectasis.
  • Short rib-polydactyly syndrome, Majewski type: A rare genetic disorder which is a lethal form of short-limb dwarfism and is characterized by short stature, disproportionately short limbs, extra fingers and toes and other deformities.
  • Short stature -- Robin sequence -- cleft mandible -- hand anomalies -- clubfoot: A very rare syndrome characterized mainly by short stature, a cleft in the lower jaw, hand anomalies, club foot and mouth abnormalities (Robin sequence).
  • Short stature -- talipes -- natal teeth: A very rare syndrome characterized mainly by short stature, early tooth eruption, and a foot deformity (talipes).
  • Sillence syndrome: An extremely rare genetic disorder primarily involving digit abnormalities, scoliosis and club feet.
  • Skewfoot: A foot deformity where the front part of the foot is skewed or bent sideways.
  • Sommer-Hines syndrome: A very rare syndrome characterized by the presence of only one finger (fifth finger) on each hand and one toe (fifth toe) on each foot.
  • Spinal stenosis: Narrowing of the spinal cavity around the spinal cord.
  • Split Hand/Split Foot Malformation: A condition which is characterized by a malformation of the hand or foot
  • Split hand -- split foot: A rare malformation where the middle digits and associated hand or foot bones are missing, giving the hand and foot a split appearance. One or more limbs may be affected and sometimes the remaining digits are webbed which can give them a "lobster-claw" like appearance.
  • Split hand -- split foot -- deafness: A syndrome characterized by deafness at birth and a hand and foot malformation.
  • Split hand split foot mandibular hypoplasia: A very rare condition characterized by a split hand or foot deformity, kidney abnormalities and underdeveloped lower jaw.

 

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