Hyperkalemic periodic paralysis: A rare inherited genetic condition characterized by temporary periods of severe muscle weakness. The condition tends to be more severe in males and can be triggered by stress, fasting, rest after exercise and eating foods high in potassium. More detailed information about the symptoms, causes, and treatments of Hyperkalemic periodic paralysis is available below.
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An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481) - (Source - Diseases Database)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Hyperkalemic periodic paralysis as a "rare disease".
Source - Orphanet
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