Types of Hypokalemic periodic paralysis
Types discussion:
The
two most common types of periodic paralyses are hypokalemic (caused by
mutations in the calcium channel gene on chromosome 1) and hyperkalemic
(caused by mutations in the sodium channel on chromosome 17). Hypokalemic
periodic paralysis, which is often referred to as familial, is
characterized by a fall in potassium levels in the blood. Hypokalemic
attacks are usually triggered by exercising too strenuously, eating too
many carbohydrates, or taking drugs such as insulin. Attacks of
hypokalemic periodic paralysis begin in adolescence and may last for a few
hours or persist for several days. Some patients may develop a fixed
muscle weakness later in life. Hyperkalemic attacks, which are frequent
and brief (lasting 1 to 2 hours), are usually triggered by strenuous
exercise, stress, ingestion of certain foods, and administration of
potassium. Individuals with hyperkalemic periodic paralysis may display a
rise in potassium levels in the blood during attacks. Some attacks may be
accompanied by myotonia (the inability to immediately relax a contracted
muscle). Hyperkalemic attacks often begin at an early age (infancy to
early childhood). Heart arrhythmias may also develop during these attacks
in some families.
(Source: excerpt from NINDS Periodic Paralyses Information Page: NINDS)
Hypokalemic periodic paralysis: Rare Types
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