IgA nephropathy: IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. ... more about IgA nephropathy.
IgA nephropathy: A rare disorder where kidney inflammation leads to a build up of the antibody (IgA) in the kidney which results in the characteristic symptom of blood in the urine. More detailed information about the symptoms, causes, and treatments of IgA nephropathy is available below.
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IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli (the singular form is glomerulus) normally filter wastes and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. If this disorder leads to end-stage renal disease, the patient must go on dialysis or receive a kidney transplant. (Source: excerpt from IgA Nephropathy: NIDDK)
Most common cause of primary glomerular disease in Europe, Australia, and United States; lesions formed as a consequence of mesangial formations of immune deposits composed of IgA. - (Source - Diseases Database)
IgA nephropathy is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that IgA nephropathy, or a subtype of IgA nephropathy,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list IgA nephropathy as a "rare disease".
Source - Orphanet
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