Treatments for Kidney damage -- Cyclophosphamide

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Treatment List for Kidney damage -- Cyclophosphamide

The list of treatments mentioned in various sources for Kidney damage -- Cyclophosphamide includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.

Removal of toxin from body, monitoring and support of kidney function, dialysis if needed, kidney transplant in severe cases
Treatment of kidney damage from cyclophosphamide is dependant upon the severity of damage and the degree of spontaneous recovery, as well as the patients' age, pre-existing renal function and coexisting health problems. Treatments include:
- Removal from further exposure to the causative agent
- Supportive therapy in the acute phase
  - Fluid and electrolyte management
  - Management of hypertension
  - Dialysis for acute severe renal failure
- Longer term management:
  - Monitoring of renal function to ascertain degree of spontaneous recovery
  - Avoidance of medications that may contribute to further renal damage - NSAID's, IV contrast
  - Smoking cessation - people who continue to smoke increase their risk of progression to end stage renal failure
  - Close management of high blood pressure - ACE (Angiotensin converting enzyme) inhibitors and ARB's (Angiotensin II receptor blockers) usually first line
- Dietary management
  - Protein management dependant upon urinary protein loss and degree of renal impairment. Protein intake needs to be adequate to avoid malnutrition
  - Sodium management as required. May need to be restricted, or supplemented if salt wasting occurs
  - Adequate hydration
  - Phosphate restriction in chronic renal failure
  - Potassium restriction as necessary
- Management of chronic renal failure:
  - Erythropoietin agonists - for management of anaemia associated with chronic renal failure
  - Phosphate binders - for management of hyperphosphatemia in chronic renal failure
  - Calcium supplements - for hypocalcaemia
  - Calcitriol and other Vitamin D supplements - for hypocalcaemia and hyperparathyroidism associated with chronic renal failure
  - Sodium bicarbonate - for acid-base disturbance
  - Diuretics - may be used in situation of volume overload
  - Renal dialysis - used when there are manifestations of uraemia and the GFR is < 10mL/min
    - Haemodialysis
    - Peritoneal dialysis
  - Renal transplantation

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