Krabbé Disease: Introduction
Krabbé Disease: Brain myelin disorder with various symptoms.
More detailed information about the symptoms,
causes, and treatments of Krabbé Disease is available below.
Symptoms of Krabbé Disease
See full list of 8
symptoms of Krabbé Disease
Treatments for Krabbé Disease
Read more about treatments for Krabbé Disease
Home Diagnostic Testing
Home medical testing related to Krabbé Disease:
- Brain & Neurological Disorders: Related Home Testing:
Wrongly Diagnosed with Krabbé Disease?
Krabbé Disease: Related Patient Stories
Krabbé Disease: Complications
Read more about complications of Krabbé Disease.
Causes of Krabbé Disease
Read more about causes of Krabbé Disease.
Krabbé Disease: Undiagnosed Conditions
Commonly undiagnosed diseases in related medical categories:
Misdiagnosis and Krabbé Disease
Undiagnosed stroke leads to misdiagnosed aphasia: BBC News UK reported on a man who
had been institutionalized and treated for mental illness
because he suffered from sudden inability to speak...read more »
Dementia may be a drug interaction: A common scenario in aged care is for
a patient to show mental decline to dementia.
Whereas this can, of course, occur due to various medical conditions,
such as a stroke or ...read more »
Mild traumatic brain injury often remains undiagnosed: Although the symptoms
of severe brain injury are hard to miss,
it is less clear for milder injuries, or even those causing a mild concussion diagnosis.
The condition goes by the...read more »
MTBI misdiagnosed as balance problem: When a person has symptoms
such as vertigo or dizziness, a diagnosis of brain injury may go overlooked.
This is particularly true of mild traumatic brain...read more »
Brain pressure condition often misdiagnosed as dementia: A condition
that results from an excessive pressure of CSF within the brain is often misdiagnosed.
It may be misdiagnosed as Parkinson's disease or dementia (such as ...read more »
Post-concussive brain injury often misdiagnosed: A study found that soldiers who had
suffered a concussive injury in battle often were...read more »
Children with migraine often misdiagnosed: A migraine often fails to be
correctly diagnosed in pediatric patients.
These patients are not the...read more »
Read more about Misdiagnosis and Krabbé Disease
Krabbé Disease: Research Doctors & Specialists
Research related physicians and medical specialists:
- Neurology (Brain/CNS Specialists):
- Stroke & Vascular Specialists:
- Senior Health Specialists (Geriatrics):
- more specialists...»
Other doctor, physician and specialist research services:
Krabbé Disease: Rare Types
Rare types of diseases and disorders in related medical categories:
Krabbé Disease: Animations
More Krabbé Disease animations & videos
Prognosis for Krabbé Disease
Prognosis for Krabbé Disease:
poor. Typically fatal by age 2.
More about prognosis of Krabbé Disease
Research about Krabbé Disease
Visit our research pages for current research about Krabbé Disease treatments.
Clinical Trials for Krabbé Disease
The US based website ClinicalTrials.gov lists information on both federally
and privately supported clinical trials using human volunteers.
Some of the clinical trials listed on ClinicalTrials.gov for Krabbé Disease include:
Read more about Clinical Trials for Krabbé Disease
Statistics for Krabbé Disease
Krabbé Disease: Broader Related Topics
Types of Krabbé Disease
Krabbé Disease Message Boards
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Read about other experiences, ask a question about Krabbé Disease, or answer someone else's question, on our message boards:
Definitions of Krabbé Disease:
A degenerative disease of the central and peripheral nervous system caused by abnormal breakdown and turnover of myelin and marked by reduced galacosylceramide beta-galactosidase activity (EC 18.104.22.168). Two types based on the age of onset are recognized: Infantile-onset Krabbe disease is marked by the appearance of symptoms at ages 3-6 months, which include irritability, frequent crying, and increase of muscle tonus. They are followed by opisthotonos, less of tendon reflexes, visual failure, elevated cerebrospinal fluid proteins, and delayed nerve conduction velocity. Most infants die during the second year of life. Late-onset Krabbe disease (LOKD) has first symptoms at ages 5 to 10 years, consisting of focal neurological signs, hemiparesis, cerebellar ataxia, cortical blindness, and spastic paraplegia, followed by mental and physical deterioration. Some patients survive into adulthood.
- (Source - Diseases Database)
Krabbé Disease is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Krabbé Disease, or a subtype of Krabbé Disease,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Ophanet, a consortium of European partners,
currently defines a condition rare when it affects 1 person per 2,000.
They list Krabbé Disease as a "rare disease".
Source - Orphanet
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