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What is Krabbe leukodystrophy?

What is Krabbe leukodystrophy?

  • Krabbe leukodystrophy: A rare inherited biochemical disorder involving the deficiency of an enzyme called galactocerebrosidase. It is a leukodystrophy which refers to a group of genetic disorders that affect the growth of the protective coating around the brain nerves.

Krabbe leukodystrophy is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Krabbe leukodystrophy, or a subtype of Krabbe leukodystrophy, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Krabbe leukodystrophy: Introduction

Types of Krabbe leukodystrophy:

Broader types of Krabbe leukodystrophy:

How many people get Krabbe leukodystrophy?

Prevalance of Krabbe leukodystrophy: 1 per 100,000 people are affected by Krabbe disease in the US, Genetics Home Reference website
Prevalance Rate of Krabbe leukodystrophy: approx 1 in 100,000 or 0.00% or 2,720 people in USA [about data]

Who gets Krabbe leukodystrophy?

Profile for Krabbe leukodystrophy: Onset of the disorder generally occurs at 3 to 6 months of age, but juvenile and even adult-onset patients are known. (Source: excerpt from NINDS Krabbe Disease Information Page: NINDS)

How serious is Krabbe leukodystrophy?

Complications of Krabbe leukodystrophy: see complications of Krabbe leukodystrophy
Prognosis of Krabbe leukodystrophy: The prognosis for individuals with Krabbé disease is poor. The disorder is generally fatal before age 2. Prognosis may be significantly better with early bone marrow transplantation in some patients. (Source: excerpt from NINDS Krabbe Disease Information Page: NINDS)

What causes Krabbe leukodystrophy?

Causes of Krabbe leukodystrophy: see causes of Krabbe leukodystrophy

What are the symptoms of Krabbe leukodystrophy?

Symptoms of Krabbe leukodystrophy: see symptoms of Krabbe leukodystrophy

Complications of Krabbe leukodystrophy: see complications of Krabbe leukodystrophy

Can anyone else get Krabbe leukodystrophy?

More information: see contagiousness of Krabbe leukodystrophy
Inheritance: see inheritance of Krabbe leukodystrophy

Krabbe leukodystrophy: Testing

Diagnostic testing: see tests for Krabbe leukodystrophy.

Misdiagnosis: see misdiagnosis and Krabbe leukodystrophy.

How is it treated?

Doctors and Medical Specialists for Krabbe leukodystrophy: Medical Geneticist, Neurologist, Medical Geneticist ; see also doctors and medical specialists for Krabbe leukodystrophy.
Treatments for Krabbe leukodystrophy: see treatments for Krabbe leukodystrophy

Name and Aliases of Krabbe leukodystrophy

Main name of condition: Krabbe leukodystrophy

Other names or spellings for Krabbe leukodystrophy:

Leukodystrophy, Krabbe's, Krabbe disease, Globoid cell leukodystrophy, GCL, Globoid cell leukoencephalopathy, Galactosylceramide beta-galactosidase deficiency, GALC deficiency, GLD, Galactocerebrosidase deficiency

GALC deficiency, GCL, GLD, Galactocerebrosidase deficiency, Galactosylceramide beta-galactosidase deficiency, Globoid cell leukodystrophy, Globoid cell leukoencephalopathy, Krabbe disease
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Krabbe leukodystrophy: Related Conditions

Research the causes of these diseases that are similar to, or related to, Krabbe leukodystrophy:


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