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Leigh syndrome

Leigh syndrome: Introduction

Leigh syndrome: A rare, progressive, neurological disorder characterized by the degeneration of the brain and impaired function of various body organs. The condition is caused by a systemic deficiency of the cytochrome C oxidase enzyme. More detailed information about the symptoms, causes, and treatments of Leigh syndrome is available below.

Symptoms of Leigh syndrome

Home Diagnostic Testing

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Wrongly Diagnosed with Leigh syndrome?

Leigh syndrome: Related Patient Stories

Leigh syndrome: Deaths

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Leigh syndrome: Complications

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Causes of Leigh syndrome

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Disease Topics Related To Leigh syndrome

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Less Common Symptoms of Leigh syndrome

Leigh syndrome: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Leigh syndrome

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple...read more »

Leigh syndrome: Research Doctors & Specialists

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Evidence Based Medicine Research for Leigh syndrome

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Research about Leigh syndrome

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Statistics for Leigh syndrome

Leigh syndrome: Broader Related Topics

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Definitions of Leigh syndrome:

A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850). - (Source - Diseases Database)

Leigh syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Leigh syndrome, or a subtype of Leigh syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Leigh syndrome as a "rare disease".
Source - Orphanet

Related Leigh syndrome Info

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Forum Discussions about Leigh syndrome

More information about Leigh syndrome

  1. Leigh syndrome: Introduction
  2. Symptoms
  3. Causes
  4. Treatments
  5. Misdiagnosis
  6. Home Testing
  7. Deaths
  8. Complications
 

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