Letterer-Siwe disease: Introduction
Letterer-Siwe disease: A rare usually fatal condition characterized by skin lesions, bleeding tendency, enlarged liver and spleen, enlarged lymph nodes and progressive anemia. The condition is caused by excessive proliferation of histiocytes.
More detailed information about the symptoms,
causes, and treatments of Letterer-Siwe disease is available below.
Symptoms of Letterer-Siwe disease
See full list of 22
symptoms of Letterer-Siwe disease
Home Diagnostic Testing
Home medical testing related to Letterer-Siwe disease:
Wrongly Diagnosed with Letterer-Siwe disease?
Letterer-Siwe disease: Related Patient Stories
Letterer-Siwe disease: Deaths
Read more about Deaths and Letterer-Siwe disease.
Letterer-Siwe disease: Complications
Review possible medical complications related to Letterer-Siwe disease:
Causes of Letterer-Siwe disease
Read more about causes of Letterer-Siwe disease.
Disease Topics Related To Letterer-Siwe disease
Research the causes of these diseases that are similar to, or related to, Letterer-Siwe disease:
Misdiagnosis and Letterer-Siwe disease
Unnecessary hysterectomies due to undiagnosed bleeding disorder in women: The bleeding disorder
called Von Willebrand's disease is quite common in women,...read more »
Psoriasis often undiagnosed cause of skin symptoms in children: Children who suffer
from the skin disorder called psoriasis can often go undiagnosed.
The main problem is...read more »
Read more about Misdiagnosis and Letterer-Siwe disease
Letterer-Siwe disease: Research Doctors & Specialists
Research related physicians and medical specialists:
Other doctor, physician and specialist research services:
Evidence Based Medicine Research for Letterer-Siwe disease
Medical research articles related to Letterer-Siwe disease include:
Click here to find more evidence-based articles on the TRIP Database
Letterer-Siwe disease: Animations
More Letterer-Siwe disease animations & videos
Research about Letterer-Siwe disease
Visit our research pages for current research about Letterer-Siwe disease treatments.
Clinical Trials for Letterer-Siwe disease
The US based website ClinicalTrials.gov lists information on both federally
and privately supported clinical trials using human volunteers.
Some of the clinical trials listed on ClinicalTrials.gov for Letterer-Siwe disease include:
- Umbilical Cord Blood and Placental Blood Transplantation in Treating Patients With Hematologic Cancer or Aplastic Anemia - This study is currently recruiting patients (Current: 23 Nov 2006)
- Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer - This study is currently recruiting patients (Current: 23 Nov 2006)
- Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - anti-thymocyte globulin,busulfan,cyclophosphamide,cyclosporine,fludarabine phosphate,melphalan,methylprednisolone
- Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis - This study is currently recruiting patients (Current: 23 Nov 2006) - leucovorin calcium,methotrexate,prednisolone,vinblastine
- T-Cell Depletion and Stem Cell Transplant for Immune Deficiencies and Histiocytic Disorders - This study is currently recruiting patients (Current: 23 Nov 2006) - busulfan, cyclophosphamide, and antithymocyte globulin (ATG)
- more trials...»
See full list of 16
Clinical Trials for Letterer-Siwe disease
Statistics for Letterer-Siwe disease
Letterer-Siwe disease: Broader Related Topics
Types of Letterer-Siwe disease
User Interactive Forums
Read about other experiences, ask a question about Letterer-Siwe disease, or answer someone else's question, on our message boards:
Definitions of Letterer-Siwe disease:
A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes. -- 2003
- (Source - Diseases Database)
Letterer-Siwe disease is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Letterer-Siwe disease, or a subtype of Letterer-Siwe disease,
affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)
Contents for Letterer-Siwe disease: