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Leukemia, Myeloid, Philadelphia-Negative

Leukemia, Myeloid, Philadelphia-Negative: Introduction

Leukemia, Myeloid, Philadelphia-Negative: Acute lymphocytic leukemia is a relatively aggressive cancer of the white blood cells. Precursors to white blood cells are called blasts and are made by the bone marrow but in ALL the blasts are abnormal and do not develop into lymphocytes. Instead, the abnormal blasts or leukemic cells multiply rapidly and reduce the level of other types of blood cells such as red blood cells and platelets. The Philadelphia negative form of the condition is not associated with a genetic mutation. It is distinguished from the positive form by the clinical course which is initially the same but progresses to eventual bone marrow failure without a distinct increase in blast cells. Other differences include poor response to chemotherapy, lower white blood cell counts, greater monocytosis, less basophilia, lower bone marrow myeloid to erythroid ratio and increased likelihood of developing thrombocytopenia. Philadelphia negative patients also tend to be older and median survival rates tend to be poorer. More detailed information about the symptoms, causes, and treatments of Leukemia, Myeloid, Philadelphia-Negative is available below.

Symptoms of Leukemia, Myeloid, Philadelphia-Negative

Treatments for Leukemia, Myeloid, Philadelphia-Negative

  • Patients with Philadelphia negative CML generally have a poorer response to therapy than Philadelphia positive patients
  • Tyrosinase kinase inhibitors - Imatinib, Dasatinib, and Nilotinib. Imatinib is the first line therapy for many people, and those unsuitable for stem cell transplantation
  • Stem Cell transplantation- peripheral or bone marrow
  • Chemotherapy - used when tyrosine kinase inhibitors stop working or with stem cell transplantation
  • Interferon - used when other drugs don't work, or when they can't be used, such as in pregnancy
  • more treatments...»

Home Diagnostic Testing

Home medical testing related to Leukemia, Myeloid, Philadelphia-Negative:

Wrongly Diagnosed with Leukemia, Myeloid, Philadelphia-Negative?

Leukemia, Myeloid, Philadelphia-Negative: Complications

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Causes of Leukemia, Myeloid, Philadelphia-Negative

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Leukemia, Myeloid, Philadelphia-Negative: Undiagnosed Conditions

Commonly undiagnosed diseases in related medical categories:

Misdiagnosis and Leukemia, Myeloid, Philadelphia-Negative

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Spitz nevi misdiagnosed as dangerous melanoma skin cancer: One possible misdiagnosis to consider in lieu of melanoma is spitz nevi. See melanoma and spitz nevi....read more »

Leukemia, Myeloid, Philadelphia-Negative: Research Doctors & Specialists

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Hospitals & Clinics: Leukemia, Myeloid, Philadelphia-Negative

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Choosing the Best Hospital: More general information, not necessarily in relation to Leukemia, Myeloid, Philadelphia-Negative, on hospital performance and surgical care quality:

Leukemia, Myeloid, Philadelphia-Negative: Rare Types

Rare types of diseases and disorders in related medical categories:

Leukemia, Myeloid, Philadelphia-Negative: Animations

Research about Leukemia, Myeloid, Philadelphia-Negative

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Clinical Trials for Leukemia, Myeloid, Philadelphia-Negative

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Leukemia, Myeloid, Philadelphia-Negative include:

Leukemia, Myeloid, Philadelphia-Negative: Broader Related Topics

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More information about Leukemia, Myeloid, Philadelphia-Negative

  1. Leukemia, Myeloid, Philadelphia-Negative: Introduction
  2. Symptoms
  3. Causes
  4. Treatments
  5. Misdiagnosis
  6. Home Testing
  7. Types
  8. Complications
 

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