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Conditions by People Affected (Prevalence or Incidence)

Conditions here are listed by a combined measure of either prevalence or incidence. This gives an approximate measure of the "people affected" by the condition in any year. Prevalence refers to the total pool of people affected, whereas incidence is the annual number of new cases. Lifelong diseases like diabetes can have a low incidence but a large cumulative prevalence count, whereas short-lived diseases like flu can have a high incidence but a low prevalence. For comparison between prevalence and incidence rates see also our conditions by prevalence and conditions by incidence. See also details about prevalence and incidence statistics for more information.

In most cases, the prevalence counts and incidence rates refer to the USA or other industrialized nations. Our estimates show 274 conditions affecting a million or more Americans, 181 conditions between 100,000 and a million, and 19757 conditions of less than 100,000 US people.

Condition Percent Rate US People Data
1. Diarrhea 100.00% 1 in 1 272 million almost 100% annually (NIDDK)
2. Common Headache 90.00% 1 in 1 244.8 million 90% approximately; almost everyone gets some each year.
3. Respiratory conditions 78.90% 1 in 1 214.6 million 78.9 per 100 (NHIS96)
4. Nonsyndromic deafness 70.00% 1 in 1 190.4 million 70-80% of cases of congenital hearing loss are not associated with any syndrome in the US, Genetics Home Reference website
5. Dental caries 55.57% 1 in 2 151.2 million 2,534,161 annual cases in Victoria 1996 (DHS-VIC)
6. Cytomegalovirus 50.00% 1 in 2 136 million 50% approximately; almost half of young adults (NIAID)
7. Cold sores 50.00% 1 in 2 136 million estimated 50 to 80% of Americans have HSV-1
8. Refractive Eye Disorders 44.12% 1 in 2 120 million 120 million people
9. High Cholesterol 37.13% 1 in 3 101 million estimated 101 million Americans have cholesterol >= 200 mg/dL (CDC)
10. Infectious Diarrhea 36.40% 1 in 3 99 million 99 million new cases in the USA 1980 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
11. Flu 36.00% 1 in 3 97.9 million 36 per 100 (NHIS96); 35 million annually up to 50 million annually (NIAID/CDC); 10-20% yearly (NIAID)
12. Overweight 35.70% 1 in 3 97.1 million 97.1 million American adults
13. Chronic Illness 33.09% 1 in 3 90 million 90 million people in USA (CDC)
14. Tetrahydrobiopterin Deficiency 30.00% 1 in 3 81.6 million 30% of infants born with high phenylalanine levels have tetrahydrobiopterin deficiency in China, Genetics Home Reference website
15. Familial atrial fibrillation 30.00% 1 in 3 81.6 million estimated 30% of cases of atrial fibrillation are inherited (familial), Genetics Home Reference website
16. Food poisoning 27.94% 1 in 3 76 million about 76 million cases annually in USA (NIDDK)
17. Myopia 25.74% 1 in 3 70 million 70 million Americans; over 25 percent of all adult Americans.
18. Insulin Resistance 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
19. Metabolic Syndrome 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
20. Genital herpes 24.63% 1 in 4 67 million 67 million people (NIAID)
21. Sexually Transmitted Diseases 23.90% 1 in 4 65 million 65 million people living with an incurable STD (CDC)
22. Common cold 22.79% 1 in 4 62 million 62 million cases (NIAID); 23.6 per 100 (NHIS96); estimated 1 billion colds in the USA annually; Children get 6-10 yearly, adults 2-4 yearly; over 60's less than 1 a year.
23. Cardiovascular Disease 22.72% 1 in 4 61.8 million 61,800,000 cases in the USA (American Heart Association, 2004)
24. Hyperopia 22.40% 1 in 4 60.9 million 22.4% of population self-reported having long-sightedness in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
25. Smoking 22.30% 1 in 4 60.7 million 22.3% of Americans smoke (CDC); 23 million American women smoke (NHLBI)
26. Mental illness 22.10% 1 in 4 60.1 million about 22.1 percent of American adults annually or 44.3 million people (NIMH)
27. Toxoplasmosis 22.06% 1 in 4 60 million More than 60 million in USA but few have symptoms (DPD)
28. Digestive Diseases 22.06% 1 in 4 60 million 60 to 70 million cases in the USA 1985 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447)
29. Injury 21.69% 1 in 4 59 million 59 million cases (IOM)
30. Epstein-Barr virus 20.00% 1 in 5 54.4 million as many as 20% of people carry the virus in their throats
31. Hypertension 18.38% 1 in 5 50 million 50 million Americans (NHLBI); 217 per 1000 (NHIS95)
32. Dandruff 18.38% 1 in 5 50 million 50 million
33. Allergies 18.38% 1 in 5 50 million 50-60 million (NIAID); 9-16% (NIAID); 50 million cases annually (NIAID); 10% of American women (NHWIC); 8,526,000 children respiratory allergies (NHIS-97); 7,304,000 children non-respiratory allergies (NHIS-97)
34. Headache 16.54% 1 in 6 45 million 45 million Americans get chronic headaches. 20 million American women (NWHIC).
35. Chronic headache 16.54% 1 in 6 45 million estimated 45 million Americans (NINDS)
36. Astigmatism 16.54% 1 in 6 45 million 45 million Americans (dubious estimate based on "two thirds of people with myopia also have astigmatism")
37. Impaired glucose tolerance 15.07% 1 in 6 41 million estimated 41 million people aged 40-74 have pre-diabetes in the US 1988-94 (National Diabetes Statistics fact sheet, NIDDK, 2003)
38. Premenstrual syndrome 15.00% 1 in 6 40.8 million 30-40% women suffer some impairment of daily activity (NWHIC); 75% women have some symptoms; 3-8% women have severe PMS (NWHIC).
39. Hives 15.00% 1 in 6 40.8 million about 15% Americans each year (NWHIC)
40. Orthopedic disorders 14.90% 1 in 6 40.5 million 149 per 1000 - NHIS95
41. Sleep disorders 14.71% 1 in 6 40 million approximately 40 million Americans (NHLBI)
42. Obesity 14.63% 1 in 6 39.8 million 39.8 million American adults; more than 57% of American adults are overweight (CDC)
43. Arthritis 13.60% 1 in 7 37 million 37 million Americans (NIAMS)
44. Sinusitis 13.60% 1 in 7 37 million 37 million annually in the USA; 33 million reported to CDC (NIAID)
45. Hay fever 12.87% 1 in 7 35 million 35 million Americans (NIAID: pollen allergies)
46. Pollen allergy 12.87% 1 in 7 35 million estimated 35 million Americans with pollen allergies (NIAID)
47. Androgenetic alopecia 12.87% 1 in 7 35 million estimated 35 million men suffer from androgenetic alopecia in the US, Genetics Home Reference website
48. Chronic Sinusitis 12.83% 1 in 7 34.9 million 12.6% (NIAID); 152 per 1000 - NHIS95
49. Insomnia 11.76% 1 in 8 32 million 32 million (unreliable estimate)
50. Chronic lower respiratory diseases 11.76% 1 in 8 32 million estimated 32 million including 15 million undiagnosed
51. Lung conditions 11.03% 1 in 9 30 million more than 30 million Americans with chronic lung diseases (NWHIC)
52. Impotence 11.03% 1 in 9 30 million 30 million men (NIDDK)
53. Lactose Intolerance 11.03% 1 in 9 30 million 30 million people to 50 million people (NIDDK 1994); about 25% of population (1994/NIDDK)
54. Osteoporosis 10.29% 1 in 9 28 million 28 million Americans (10 million with osteoporosis; 18 million with low bone mass); eight million American women and 2 million men (NWHIC)
55. Migraine 10.29% 1 in 9 28 million 28 million Americans (NINDS)
56. Mole 10.00% 1 in 10 27.2 million common; most people have 10-40 moles.
57. Molluscum contagiosum 10.00% 1 in 10 27.2 million Common.
58. Scabies 10.00% 1 in 10 27.2 million common
59. Retroverted uterus 10.00% 1 in 10 27.2 million about 1 in 5 women
60. Allergic rhinitis 10.00% 1 in 10 27.2 million 10% of the population with allergic rhinitis/hay fever in the US (Mayo Clinic)
61. Otosclerosis 10.00% 1 in 10 27.2 million as many as 10% of Caucasians have the condition but most do not get symptoms; about 1 in 100 cases actually lose hearing from otosclerosis
62. Extra Nipples 10.00% 1 in 10 27.2 million about 1 in 10 people but most are small and mistaken for freckles or moles
63. Glucose-6-Phosphate Dehydrogenase Deficiency 10.00% 1 in 10 27.2 million 1 in 10 African-American males suffer from glucose-6-phosphate dehydrogenase deficiency in the US, Genetics Home Reference website
64. Amyotrophic lateral sclerosis, familial 10.00% 1 in 10 27.2 million 10% of all cases of amyotrophic lateral sclerosis are familial, Genetics Home Reference website
65. Depressive disorders 9.50% 1 in 10 25.8 million 9.5 percent of adult Americans (NIMH)
66. Rare diseases 9.19% 1 in 10 25 million about 25 million Americans (ORD); each disease less than 200,000 Americans by definition.
67. Presbyopia 9.00% 1 in 11 24.5 million 9.0% of population self-reported having presbyopia in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
68. Back Impairment 8.50% 1 in 11 23.1 million 85 per 1000 - NHIS95 (deformity or orthopedic impairment of back)
69. Heart disease 8.09% 1 in 12 22 million 22 million adults in the US 2000 (Centers for Disease Control and Prevention)
70. Hearing Impairment 8.09% 1 in 12 22 million 22 million; 158 per 1000 (NHIS95)
71. Thyroid disorders 7.35% 1 in 13 20 million 20 million Americans (NWHIC)
72. Human Papillomavirus 7.35% 1 in 13 20 million 20 million Americans currently infected (NIAID; CDC 2001)
73. Osteoarthritis 7.35% 1 in 13 20 million 20 million people (NIAMS); more than 16 million people (NWHIC)
74. Mood disorders 7.10% 1 in 14 19.3 million estimated 7.1% adults (USSG)
75. Ischemic heart disease 6.80% 1 in 14 18.5 million 68 per 1000 (NHIS95)
76. Sleep apnea 6.62% 1 in 15 18 million estimated 18 million Americans (NHLBI)
77. Asthma 6.40% 1 in 15 17.4 million 6.4% USA (NIAID); 17 million Americans (NIAID) including 5 million children; 8.1 million children (NHIS-97), 51 per 1000 - NHIS95; 14.5 million; 5% of population (NWHIC); 14.9 million in 1995 (NHLBI)
78. Acne 6.25% 1 in 16 17 million 17 million Americans, almost 85% of people 12-24 years of age.
79. Diabetes 5.88% 1 in 17 16 million 16 million Americans with 10.3 million diagnosed and 8.1 million women (NWHIC); 65 per 1000 - NHIS95; 8 million - perhaps 16 million if include not-yet-diagnosed.
80. Type 2 diabetes 5.88% 1 in 17 16 million 16 million Americans (NWHIC, includes undiagnosed); 7.2 million (actually diagnosed)
81. Gallstones 5.88% 1 in 17 16 million 16 to 22 million people in the USA 1976-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, NIDDK, 1994)
82. Crouzon Syndrome 5.88% 1 in 17 16 million 16 million newborns suffer from Crouzon syndrome, Genetics Home Reference website
83. Alcoholism 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
84. Alcohol abuse 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
85. Eczema 5.51% 1 in 18 15 million 15 million people (NIAMS); 10% infants/children estimated (NIAMS); 9% (NIAID); 8.5 million
86. Gynecomastia 5.51% 1 in 18 15 million 15 million - 15% of adult men to some extent (unreliable estimate)
87. Heartburn 5.51% 1 in 18 15 million 15 million Americans have it daily (NIDDK)
88. Depression 5.30% 1 in 18 14.4 million estimated 5.3% adults (USSG); 17 million people; approximately 4% of adolescents get seriously depressed (NIMH); annually 12% of women ; 7% of men; lifetime risk of an episode for women 20%. 3-4 million men USA.
89. Arrhythmias 5.30% 1 in 18 14.4 million 53 per 1000 (NHIS95: heart rhythm disorders); 21 per 1000 (NHIS95: heart murmurs)
90. Urinary stones 5.20% 1 in 19 14.1 million 5.2% of adults in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
91. Raynaud's phenomenon 5.00% 1 in 20 13.6 million 5-10% (NIAMS estimate). Scleroderma-related disorders including Raynaud's phenomenon between 250,000 and 992,500.
92. Uterine fibroids 5.00% 1 in 20 13.6 million 10-20% women (NWHIC)
93. Endometriosis 5.00% 1 in 20 13.6 million 10 to 20 percent of American women of childbearing age have endometriosis (NIDCD); up to 2 million women in the UK.
94. Red-green color blindness 5.00% 1 in 20 13.6 million about 10% of males
95. Congenital myotonic dystrophy 5.00% 1 in 20 13.6 million 5 per 100 000 people suffer from myotonic dystrophy in the US
96. X-linked adrenoleukodystrophy -- Addison disease only 5.00% 1 in 20 13.6 million 10% of males with X-linked adrenoleukodystrophy have the Addison only form of the disease, Genetics Home Reference website
97. COPD 4.96% 1 in 20 13.5 million 13.5 million Americans (NHLBI)
98. Coronary heart disease 4.85% 1 in 20 13.2 million estimated 13,200,000 in the USA 2001 (American Heart Association, 2004)
99. Urinary Incontinence 4.78% 1 in 20 13 million 13 million adults (NIDDK); 1 in 10 over 65 (NWHIC).
100. Rosacea 4.78% 1 in 20 13 million 13 million people in the United States (NIAMS)
101. Acute Bronchitis 4.60% 1 in 21 12.5 million 4.6 per 100 (NHIS96: acute bronchitis); 14.2 million cases annually
102. Varicose veins 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95)
103. Tinnitus 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95); 12 million Americans
104. Chronic Bronchitis 4.45% 1 in 22 12.1 million 12.1 million Americans (NHLBI)
105. Obstructive sleep apnea 4.41% 1 in 22 12 million 12 million Americans
106. Genetic Disease 4.41% 1 in 22 12 million 12 million Americans - unreliable estimate, (perhaps 2.5% births)
107. Phobias 4.23% 1 in 23 11.5 million 11.5 million adults (NIMH); 8.0% adults (NIMH)
108. Iron deficiency anemia 4.12% 1 in 24 11.2 million 187,979 annual cases in Victoria 1996 (DHS-VIC); 20% women of childbearing age; 2% adult men (NWHIC)
109. Cornea disorders 4.04% 1 in 24 11 million 11,000,000 people experience corneal disorders such as herpes or dry eye in the US (Research to Prevent Blindness, NISE, NSF)
110. Dysthymia 4.01% 1 in 24 10.9 million about 10.9 million American adults (NIMH); estimated 1.6% adults (USSG)
111. Presbycusis 3.90% 1 in 25 10.6 million 30-35% over 65 have some hearing loss, 40-50% over 70.
112. Hemorrhoids 3.82% 1 in 26 10.4 million 10.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
113. Social phobia 3.70% 1 in 27 10.1 million 5.3 million adult Americans (NIMH); 3.7% adults (NIMH); 2.0% adults (USSG)
114. Latent tuberculosis 3.68% 1 in 27 10 million estimated 10 to 15 million people in USA (NIAID)
115. Jaw conditions 3.68% 1 in 27 10 million estimated 10 million women in the USA (NWHIC)
116. Traveler's diarrhea 3.68% 1 in 27 10 million estimated 10 million (DBMD1)
117. Enteroviruses 3.68% 1 in 27 10 million estimated 10-15 million cases annually in USA (DVRD)
118. Age-related macular degeneration 3.68% 1 in 27 10 million 10,000,000 people have reduced vision due to age-related macular degeneration in the US (Research to Prevent Blindness, NISE, NSF)
119. Post-traumatic stress disorder 3.60% 1 in 27 9.8 million 5.2 million adult Americans (NIMH); 3.6% adults (NIMH); about 30% of war veterans.
120. Indigestion 3.50% 1 in 28 9.5 million 35 per 1000 - NHIS95 (frequent indigestion)
121. Dermatitis 3.30% 1 in 30 8 million 33 per 1000 (NHIS95)
122. Insect sting allergies 3.30% 1 in 30 8 million 3.3% (NIAID); up to 5% of the population (NHWIC)
123. Bursitis 3.20% 1 in 31 8.7 million 32 per 1000 (NHIS95)
124. Autoimmune diseases 3.13% 1 in 31 8.5 million 8,511,845 people in the USA 1996 2
125. Dry skin 3.10% 1 in 32 8.4 million 31 per 1000 - NHIS95 (trouble with dry/itching skin)
126. Disc Disorders 3.10% 1 in 32 8.4 million 31 per 1000 (NHIS95: intervertebrate disc disorders)
127. Acute urinary conditions 3.09% 1 in 32 8.4 million 8.405 million new conditions (NIDDK)
128. Acute Nonulcer dyspepsia 3.01% 1 in 33 8.2 million 8.2 million new cases (1988/NIDDK)
129. Paget's disease of bone 3.00% 1 in 33 8.2 million about 3% of people aged over 40; 10% by age 80.
130. Retinoblastoma 3.00% 1 in 33 8.2 million 3% of cancers in children under the age of 15 are due to retinoblastomas, Genetics Home Reference website
131. Congenital conditions 3.00% 1 in 33 8.2 million 3-4% of babies (NWHIC)
132. Gastroesophageal Reflux Disease 3.00% 1 in 33 8.2 million 3-7% of the population in the USA 1985 for "GERD and related esophageal disorders" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
133. Urinary tract infections (child) 3.00% 1 in 33 8.2 million 3% of girls and 1% of boys before age 11
134. Cerebrovascular Conditions 3.00% 1 in 33 8.2 million 30 per 1000 - NHIS95
135. Amyotrophic lateral sclerosis type 1 3.00% 1 in 33 8.2 million 3% of sporadic cases of amyotrophic lateral sclerosis are type 1, Genetics Home Reference website
136. Generalized anxiety disorder 2.80% 1 in 35 7.6 million 4 million adult Americans (NIMH); 2.8% adults (NIMH); estimated 3.4% adults (USSG)
137. Heart attack 2.76% 1 in 36 7.5 million 7.5 million people with AMI (NHLBI)
138. Squint 2.76% 1 in 36 7.5 million 7,500,000 people suffer from strabismus or cross eyes in the US (Research to Prevent Blindness, NISE, NSF)
139. Kidney disease 2.72% 1 in 36 7.4 million 7.4 million adults in the USA 1988-94 (American Journal of Kidney Disease)
140. Prostate conditions 2.60% 1 in 38 7.1 million 52 per 1000 men - NHIS95; 2,803 million men (NIDDK)
141. Ingrown nails 2.60% 1 in 38 7.1 million 26 per 1000 - NHIS95 (trouble with ingrown nails)
142. Middle ear infection 2.57% 1 in 38 7 million 7 million annually
143. Callus 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
144. Corns 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
145. Polycystic ovary syndrome 2.50% 1 in 40 6.8 million 5-10% women of childbearing age (20-40); 30% of women have some PCOS symptoms (NWHIC).
146. Fecal incontinence 2.39% 1 in 41 6.5 million 6.5 million Americans
147. Angina 2.35% 1 in 42 6.4 million 6.4 million Americans (NHLBI)
148. Specific phobias 2.32% 1 in 43 6.3 million estimated 6.3 million adult Americans (NIMH); estimated 8.3% adults (USSG)
149. Occupational Injuries 2.32% 1 in 43 6.3 million 6.3 million workers in 1994 (CDC-OC)
150. Obsessive-compulsive disorder 2.30% 1 in 43 6.3 million 3.3 million adult Americans (NIMH); 2.3% adults (NIMH); 1 in 50 people (NWHIC); 2.4% adults (USSG)
151. Cystitis 2.28% 1 in 43 6.2 million 6.2 million adults self-reported having a bladder infection for more than 3 months in the US 1988-1994 (Weighted Analysis of 1988-1994, NHANES, NIDDK)
152. Back pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
153. Chest pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
154. Nonulcer dyspepsia 2.13% 1 in 46 5.8 million 5.8 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
155. Anti-Social Personality Disorder 2.10% 1 in 47 5.7 million estimated 2.1% adults (USSG)
156. Periodontitis 2.07% 1 in 48 5.6 million 94,482 annual cases in Victoria 1996 (DHS-VIC)
157. Cataracts 2.02% 1 in 49 5.5 million 5,500,000 people have a cataract interfering with their vision in the US (Research to Prevent Blindness, NISE, NSF)
158. Psoriasis 2.02% 1 in 49 5.5 million 5.5 million people in the USA (NIAMS)
159. Autoimmune thyroid diseases 2.00% 1 in 50 5.4 million 4 out of 100 women some type of autoimmune thyroid disease
160. Borderline Personality Disorder 2.00% 1 in 50 5.4 million 2 percent of adults (NIMH)
161. Cyclic vomiting syndrome 2.00% 1 in 50 5.4 million 1 in 50 children (perhaps)
162. Penicillin allergy 2.00% 1 in 50 5.4 million 2-3% of people (2-3% of hospitalized patients)
163. Mitral-valve prolapse 2.00% 1 in 50 5.4 million 2% of the adult population (NHLBI estimate)
164. Hereditary nonpolyposis colon cancer 2.00% 1 in 50 5.4 million 2-7% of all colorectal cancers are due to hereditary nonpolyposis colorectal cancer
165. Bunions 1.92% 1 in 51 5.2 million 19.25 per 1000 - NHIS95 (trouble with bunions)
166. Female genital disorders 1.90% 1 in 52 5.2 million 38 per 1000 women (NHIS95)
167. Trichomoniasis 1.84% 1 in 54 5 million 5 million cases annually in the USA (CDC 2001)
168. Irritable bowel syndrome 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, 1994); 11 per 1000 (NHIS95)
169. Peptic Ulcer 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
170. Eating disorders 1.84% 1 in 54 5 million 5 million women (NWHIC); 1-4% of young women
171. Pneumonia 1.76% 1 in 56 4.8 million 4.8 million annual cases (1996); 1.8 per 100 (NHIS96)
172. Heart failure 1.76% 1 in 56 4.8 million 4.8 million (NHLBI); 2 to 3 million Americans (NHLBI)
173. Congestive Heart Failure 1.76% 1 in 56 4.8 million 4.8 million Americans (NHLBI); 2% age 40-59; 5% age 60-69; 10% over 70's
174. Panic disorder 1.70% 1 in 58 4.6 million approximately 2.4 million Americans (NIMH)
175. Atherosclerosis 1.70% 1 in 58 4.6 million 17 per 1000 - NHIS95
176. Learning disabilities 1.69% 1 in 59 4.6 million 4.6 million children (NHIS-97)
177. Stroke 1.69% 1 in 59 4.6 million estimated 4.6 million (NHLBI)
178. Automobile accidents injury 1.68% 1 in 59 4.6 million 4,563,000 cases requiring emergency department visits in 2000 (CDC)
179. Abdominal Hernia 1.65% 1 in 60 4.5 million 4.5 million people in the USA 1988-90 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
180. Constipation 1.62% 1 in 61 4.4 million 4.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
181. Edema 1.60% 1 in 62 4.4 million 1.6% of population self-reported having oedema in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
182. Tachycardia 1.60% 1 in 62 4.4 million 16 per 1000 (NHIS95)
183. Falls 1.52% 1 in 65 4.1 million 69,264 annual cases in Victoria 1996 (DHS-VIC)
184. Kidney conditions 1.50% 1 in 66 4.1 million 15 per 1000 (NHIS95: "kidney trouble")
185. Undescended Testicle 1.50% 1 in 66 4.1 million 3% of male babies; about 30% of premature male babies.
186. Childbirth 1.49% 1 in 67 4 million 4,043,000 annual live births ending Aug 2001 (NVSR 50:7 2002); 4,058,814 annually in 1999 in USA (CDC)
187. Shoulder conditions 1.47% 1 in 68 4 million about 4 million annual cases in USA (NIAMS)
188. Alzheimer's Disease 1.47% 1 in 68 4 million more than 4 million Americans (CDC); estimated 4 million people in the U.S (NHWIC)
189. Chlamydia 1.47% 1 in 68 4 million estimated 4 million cases (NIAID/CDC) [4-8 million cases] including undiagnosed (about 600,000 diagnosed).
190. Pregnancy 1.47% 1 in 68 4 million more than 4 million; 1 million adolescent U.S. females become pregnant every year
191. Drug abuse 1.47% 1 in 68 4 million more than 4 million women need treatment for drug abuse (NWHIC)
192. Chronic Hepatitis C 1.47% 1 in 68 4 million Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK).
193. Deafness 1.47% 1 in 68 4 million 4 million people (unreliable estimate)
194. Thrombotic thrombocytopenic purpura, acquired 1.47% 1 in 68 4 million estimated 4-7 million people are diagnosed with thrombotic thrombocytopenic purpura each year in the US, Genetics Home Reference website
195. Fibromyalgia 1.36% 1 in 73 3.7 million 3.7 million Americans (NIAMS)
196. Open Wound 1.32% 1 in 75 3.6 million 60,052 annual cases of open wounds in Victoria 1996 (DHS-VIC)
197. Color blindness 1.30% 1 in 76 3.5 million 13 per 1000 - NHIS95
198. Anemia 1.29% 1 in 77 3.5 million 3.5 million (NHLBI)
199. ADD 1.21% 1 in 82 3.3 million 3.3 million children have ADD in the USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
200. ADHD 1.21% 1 in 82 3.3 million 3.3 million children have ADD in the USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
201. Attention Deficit Hyperactivity Disorder 1.21% 1 in 82 3.3 million 3.3 million children have ADD in USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
202. Rheumatic fever 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95)
203. Bipolar disorder 1.20% 1 in 83 3.3 million 1.2 percent of the population; 2.3 million adult Americans (NIMH)
204. Colitis 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95: "enteritis or colitis")
205. Enteritis 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95: "enteritis or colitis")
206. Acute rheumatic fever 1.20% 1 in 83 3.3 million 12 per 1000 (NHIS95)
207. Agoraphobia 1.18% 1 in 84 3.2 million approximately 3.2 million American adults ages 18 to 54 (NIMH); estimated 4.9% adults (USSG)
208. Bladder conditions 1.15% 1 in 86 3.1 million 3.139 million cases (chronic, NIDDK); 25 per 1000 - NHIS95 (bladder disorders)
209. Graves Disease 1.12% 1 in 89 3 million 3,048,636 people in the USA 1996 2; 1.3 million people (NWHIC)
210. Pubic lice 1.10% 1 in 90 3 million 3 million new cases annually estimated (NIAID)
211. Rotavirus 1.10% 1 in 90 3 million 3 million cases in the USA each year.
212. Von Willebrand disease 1.10% 1 in 90 3 million estimated 3 million mostly undiagnosed
213. Open-angle glaucoma 1.10% 1 in 90 3 million about 3 million Americans, many not yet diagnosed.
214. Peanut allergies 1.10% 1 in 90 3 million 3 million Americans (peanut and tree nut combined; NIAID)
215. Dental conditions 1.10% 1 in 90 2 million 1.1 per 100 (NHIS96: acute dental conditions)
216. Stuttering 1.00% 1 in 100 2.7 million about 1% of adults
217. Deuteranopia 1.00% 1 in 100 2.7 million about 1% of white males
218. Protanopia 1.00% 1 in 100 2.7 million about 1% of white males
219. Food allergies 1.00% 1 in 100 2.7 million 1% of the adult population have a true immune reaction to food (NHWIC)
220. Latex allergies 1.00% 1 in 100 2.7 million 1-6% (NIAID)
221. Speech impairment 1.00% 1 in 100 2.7 million 10 per 1000 (NHIS95)
222. Glomus vagale tumors 1.00% 1 in 100 2.7 million 1% of glomus tumors are malignant
223. Gastritis 0.99% 1 in 100 2.7 million 2.7 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
224. Rheumatoid arthritis 0.92% 1 in 108 2.5 million 2.5 million Americans (NWHIC); 1% of US population (NIAMS)
225. Campylobacter food poisoning 0.92% 1 in 108 2.5 million 2.5 million cases per year (CDC estimate/NIAID); 2 million cases to 8 million cases a year
226. Paralysis 0.90% 1 in 111 2.4 million 9 per 1000 - NHIS95 (paralysis of extremeties complete/partial)
227. Vision Impairment 0.88% 1 in 113 2.4 million 2.4 million Americans
228. Death 0.88% 1 in 113 2.4 million 2,391,399 annual deaths in 1999 (NVHS Sep 2001); annual risk of dying about 0.877% (NVSR 2001)
229. Epilepsy 0.85% 1 in 118 2.3 million 2.3 million Americans (CDC)
230. Uveitis 0.85% 1 in 118 2.3 million 2,300,000 people suffer uveitis in the US (Research to Prevent Blindness, NISE, NSF)
231. Congenital heart defects 0.83% 1 in 120 2.3 million 1 million (NHLBI)
232. Schizophrenia 0.81% 1 in 123 2.2 million Approximately 2.2 million American adults (NIMH); estimated 1.3% adults (USSG); more than 2 million Americans
233. Adverse reaction 0.81% 1 in 123 2.2 million 2.2 million adverse drug reactions after administration of FDA-approved drugs in USA 1996 (American Medical Association)
234. Deviated Septum 0.80% 1 in 124 2.2 million 8 per 1000 - NHIS95
235. Glaucoma 0.74% 1 in 136 2 million 2,000,000 people are visually impaired by glaucoma in the US (Research to Prevent Blindness, NISE, NSF)
236. Vitiligo 0.74% 1 in 136 2 million 2 to 5 million people in the USA (1-2% worldwide); 1,059,560 people in the USA 1996 2
237. Male infertility 0.74% 1 in 136 2 million at least 2 million annual cases (based on NWHIC)
238. Female infertility 0.74% 1 in 136 2 million at least 2 million annual cases (based on NWHIC)
239. Diverticular Disease 0.74% 1 in 136 2 million 2 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
240. Hepatitis C 0.74% 1 in 136 2 million estimated 2 to 5 million HCV chronic carriers
241. Alcoholic liver disease 0.74% 1 in 136 2 million More than 2 million Americans (NIAAA)
242. Emphysema 0.74% 1 in 136 2 million 2 million Americans (NHLBI); 17 per 1000 - NHIS95; 2 million annually
243. Nosocomial infections 0.74% 1 in 136 2 million estimated 2 million cases annually or about 10% of American hospital patients (CDC/NNIS 1992)
244. Atrial Fibrillation 0.74% 1 in 136 2 million 2 million (NHLBI)
245. Mycoplasma pneumoniae 0.74% 1 in 136 2 million estimated 2 million cases annually (DBMD)
246. Polymyalgia rheumatica 0.70% 1 in 142 1.9 million 700 per 100,000 people over 50.
247. Chronic tonsilitis 0.70% 1 in 142 1.9 million 7 per 1000 - NHIS95 (chronic disease of tonsils or adenoids)
248. Amputation 0.70% 1 in 142 1.9 million 7 per 1000 (NHIS95: excludes toes/fingers only)
249. Binge eating disorder 0.70% 1 in 142 1.9 million 0.7% to 4% of the general population (NWHIC); 2-5% of adults (NIMH); 2% of adults (NIDDK); 2% adults or 1-2 million adults (NWHIC)
250. Birth Injury 0.70% 1 in 142 1.9 million 7 per 1,000 births3.
251. Retina Conditions 0.66% 1 in 151 1.8 million 1,800,000 people have severely impaired vision because of retinal disease in the US (Research to Prevent Blindness, NISE, NSF)
252. Hepatitis B 0.55% 1 in 181 1.5 million estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001)
253. Fractures 0.55% 1 in 181 1.5 million 1.5 million osteoporosis-related fractures
254. Bulimia nervosa 0.55% 1 in 181 1.5 million estimated 1.1 to 4.2 percent of females (NIMH); 2-3% of young women (NWHIC)
255. Hashimoto's Thyroiditis 0.55% 1 in 182 1.5 million 1,490,371 adults and 205,159 children in the USA 1996 2
256. Lupus 0.51% 1 in 194 1.4 million 1.4 million people in the United States, 1 in 85 (NWHIC)
257. Salmonella food poisoning 0.51% 1 in 194 1.4 million estimated 1.4 million cases (CDC estimate/NIAID, many unreported)
258. Mild Traumatic Brain Injury 0.51% 1 in 194 1.4 million Estimated 1.4 million MTBI injuries per year in the USA (CDC)
259. Wegener's granulomatosis 0.50% 1 in 200 1.4 million uncommon
260. HTLV 0.50% 1 in 200 1.4 million uncommon
261. HTLV-1 0.50% 1 in 200 1.4 million uncommon
262. Peyronie's disease 0.50% 1 in 200 1.4 million 1 per 100 men
263. Sebaceous cyst 0.50% 1 in 200 1.4 million 5 per 1000 - NHIS95
264. Cerebral cavernous malformations 0.50% 1 in 200 1.4 million 0.5% of people suffer from cerebral cavernous malformations worldwide, Genetics Home Reference website
265. Breast Milk Jaundice 0.50% 1 in 200 1.4 million 0.5%-2.4% of newborns develop breast milk jaundice
266. Bladder Incontinence (Pregnancy) 0.49% 1 in 203 1.3 million 1-in-3 pregnant women approximately
267. Cancer 0.46% 1 in 217 1.2 million 1,248,900 annual cases (SEER 2002 estimate)
268. Medical misadventure 0.42% 1 in 238 1.1 million 1.14 million total patient safety incidents occurred among 37 million hospitalisations in the US 2000-02 (Patient Safety in American Hospitals, Health Grades 2004)
269. Blindness 0.40% 1 in 247 1.1 million 1,100,000 people are legally blind in the US (Research to Prevent Blindness, NISE, NSF)
270. Celiac Disease 0.40% 1 in 249 1.1 million 1 in 250 Americans estimated rate; actual diagnosis rate is 1 in 4,700 Americans; 1 in 250 in Italy; 1 in 300 in Ireland; 20,000 diagnosed (Reader's Digest Feb 2004)
271. 2-methylbutyryl-coenzyme A dehydrogenase deficiency 0.40% 1 in 249 1.1 million 1 per 250 - 500 people from Hmong populations in southeast Asia and America suffer from 2-methylbutyryl-coenzyme A dehydrogenase deficiency though many are asymptomatic, Genetics Home Reference website
272. Familial Mediterranean fever 0.40% 1 in 249 1.1 million estimated 1 per 250 - 1,000 people of Armenian, Arabic, Turkish, Jewish and Mediterranean ancestry suffer from Familial Mediterranean Fever, Genetics Home Reverence website
273. Arm fracture 0.39% 1 in 255 1.1 million 17,819 annual cases in Victoria 1996 of radius/ulna (DHS-VIC)
274. Sports Injuries 0.38% 1 in 260 1 million 17,478 annual cases in Victoria 1996 (DHS-VIC)
275. Skin Cancer 0.37% 1 in 272 1 million more than 1 million annually (mostly the less dangerous types: basal and squamous)
276. Sjogren's Syndrome 0.37% 1 in 272 1 million 1 to 4 million people with Sjogren’s Syndrome (NIAMS)
277. Connective tissue disorders 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
278. Genital warts 0.37% 1 in 272 1 million 1 million annual cases in the USA (NIAID)
279. Pelvic Inflammatory Disease 0.37% 1 in 272 1 million 1 million women have a PID episode each year (NIAID)
280. Aphasia 0.37% 1 in 272 1 million 1 million Americans (NINDS)
281. Kidney stones 0.37% 1 in 272 1 million more than 1 million cases (1996, NIDDK)
282. Hemochromatosis 0.37% 1 in 272 1 million more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK); 1-in-200 to 1-in-300
283. Parkinson's Disease 0.37% 1 in 272 1 million 1 million people (unreliable estimate)
284. Dog bite 0.37% 1 in 272 1 million 1 million cases (unreliable estimate)
285. Heritable Disorders of Connective Tissue 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
286. Ankle injuries 0.37% 1 in 272 1 million 1 million annually (NIAMS); 85% are ankle sprains.
287. Hemochromatosis type 1 0.37% 1 in 272 1 million 1 million people suffer from hemochromatosis type 1 in the US, Genetics Home Reference website
288. Accidental Eye Injury 0.36% 1 in 277 978,987 16,413 annual cases in Victoria 1996 (DHS-VIC)
289. Selective IgA Deficiency 0.33% 1 in 300 906,666 1 in 300 (NIDCD); 1 in 600 (NIAID); 1 in 333 Caucasians.
290. Multiple endocrine neoplasia type 2 0.33% 1 in 300 906,666 about 1 per 300 000 people suffer from multiple endocrine neoplasia type 1 in the US, Genetics Home Reference website
291. Glutaricaciduria I 0.33% 1 in 300 906,666 estimated 1 per 300 people from the Ojibwa population of Canada suffer from glutaric academia type I, Genetics Home Reference website
292. HIV/AIDS 0.33% 1 in 302 900,000 900,000 Americans (NIAID, quarter are unaware)
293. Ankle sprain 0.31% 1 in 320 850,000 850,000 annually (NIAMS)
294. Interstitial cystitis 0.31% 1 in 321 847,000 847,000 in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
295. Neuralgia 0.30% 1 in 333 816,000 3 per 1000 - NHIS95 (neuralgia or neuritis unspecified)
296. Scoliosis 0.30% 1 in 333 816,000 3-per-1,000 to 5-per-1000 children (NIAMS)
297. Variegate porphyria 0.30% 1 in 333 816,000 approximately 3 per 1,000 white South Africans suffer from variegate porphyria, Genetics Home Reference website
298. Gonorrhea 0.29% 1 in 339 800,000 800,000 cases (CDC estimate/NIAID)
299. Chronic Hepatitis B 0.28% 1 in 362 750,000 750,000 people in the United States (NIAID)
300. Gout 0.28% 1 in 363 748,000 275 per 100,000 people (NIAMS)
301. Maple syrup urine disease 0.26% 1 in 384 706,493 estimated 1 per 385 infants suffer from maple syrup urine disease in the Old Order Mennonite population, Genetics Home Reference website
302. Spinal fracture 0.26% 1 in 388 700,000 more than 700,000 spinal fractures annually in the USA (the number caused by osteoporosis)
303. Poisoning 0.26% 1 in 391 694,829 11,649 annual cases in Victoria 1996 (DHS-VIC)
304. Edentulism 0.25% 1 in 400 681,706 11,429 annual cases in Victoria 1996 (DHS-VIC)
305. Acute Appendicitis 0.25% 1 in 400 680,000 25 per 10,000 (age 10-17), 1-2 per per 10,000 (under 4)
306. Red-green color vision defects 0.25% 1 in 400 680,000 estimated 0.5% of females of Northern European ancestry suffer from red-green color vision defects, Genetics Home Reference website
307. Pulmonary embolism 0.24% 1 in 418 650,000 approximately 650,000 cases annually in the USA
308. Bacterial vaginosis 0.24% 1 in 424 640,000 16% of pregnant women (DSTD)
309. Gall bladder conditions 0.23% 1 in 438 620,031 10,395 annual cases of gallbladder and bile duct disease in Victoria 1996 (DHS-VIC)
310. Caesarian Section 0.22% 1 in 453 600,000 more than 600,000 annually
311. Polycystic kidney disease 0.22% 1 in 453 600,000 600,000 Americans
312. Hysterectomy 0.22% 1 in 461 590,000 590,000 annually
313. Inflammatory bowel disease 0.20% 1 in 500 544,000 1 in 500 (NIAID); 300,000 people to 500,000 people NIDDK
314. Klinefelter syndrome 0.20% 1 in 500 544,000 1 per 500 - 1,000 males are affected by Klinefelter syndrome, Genetics Home Reference website
315. Congenital hip dislocation 0.20% 1 in 500 544,000 about 2 per 1000 births; up to 4 per 1000
316. Sickle Cell Anemia 0.20% 1 in 500 544,000 estimated 1 per 1,000 Hispanic Americans are affected by sickle cell disease in the US, Genetics Home Reference website
317. Autism 0.20% 1 in 500 544,000 1 in 500 to 1 in 2,500 (NIMH); 1-in-1000 to 2-in-1000, depending on diagnostic criteria
318. Nonaffective Psychosis 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
319. Somatization Disorder 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
320. Cerebral Palsy 0.20% 1 in 500 544,000 2 to 2.5 per 1,000 births (FMC)
321. Traumatic Brain Injury 0.20% 1 in 500 544,000 0.2% of population has an acquired brain injury in Australia 1998 (Australia’s Health 2004, AIHW)
322. Temporal arteritis 0.20% 1 in 500 544,000 200 per 100,000 people over 50.
323. Intussusception 0.20% 1 in 500 544,000 about 2 per 1000 cases in infants
324. Hypertrophic cardiomyopathy 0.20% 1 in 500 544,000 0.2 percent of the U.S. population
325. Sudden Infant Death Syndrome 0.20% 1 in 500 544,000 2 per 1,000
326. Gaucher disease type 1 0.20% 1 in 500 544,000 1 per 500 - 1,000 people of Ashkenazi Jewish heritage are affected by type 1 Gaucher disease, Genetics Home Reference website
327. Heterozygous Familial Hypercholesterolemia 0.20% 1 in 500 544,000 1 per 500 US people suffer from Heterozygous familial hypercholesterolemia.
328. Autosomal dominant polycystic kidney disease 0.20% 1 in 503 540,000 540,000 Americans approximately (90% of PKD)
329. Hand fracture 0.20% 1 in 507 536,287 8,991 annual cases in Victoria 1996 (DHS-VIC)
330. Crohn's disease 0.18% 1 in 544 500,000 500,000 Americans
331. Chronic Fatigue Syndrome 0.18% 1 in 544 500,000 500,000 Americans (CDC/NIAID)
332. Shingles 0.18% 1 in 544 500,000 500,000 cases (NIAID)
333. Inguinal hernia 0.18% 1 in 544 500,000 500,000 cases (NIDDK)
334. Pneumococcal pneumonia 0.18% 1 in 544 500,000 500,000 cases annually (NIAID)
335. Bedsores 0.17% 1 in 573 474,692 474,692 new cases of decubitus ulcer occurred in the US 2000-2002 (Patient Safety in American Hospitals, Health Grades 2004)
336. Viral Hepatitis 0.17% 1 in 601 452,000 about 452,000 annual cases based on incidence of HepA, HepB, HepC, and HepD (NIDDK 1990-1992)
337. Chronic Nonulcer dyspepsia 0.16% 1 in 612 444,000 444,000 new cases (1975/NIDDK)
338. Premature Birth 0.16% 1 in 618 440,000 440,000 cases (unreliable estimate)
339. Benign Prostate Hyperplasia 0.16% 1 in 627 433,216 7,263 annual cases in Victoria 1996 (DHS-VIC)
340. Liver conditions 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
341. Chronic liver disease 0.15% 1 in 679 400,000 400,000 people
342. Cirrhosis of the liver 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
343. Ocular Herpes 0.15% 1 in 679 400,000 400,000 Americans have had some form
344. Pernicious anemia 0.15% 1 in 680 399,454 399,455 people in the USA 1996 2
345. End-stage renal disease 0.14% 1 in 693 392,022 392,023 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
346. Multiple Sclerosis 0.14% 1 in 700 388,571 1-in-700 (NIAID)
347. Cleft palate 0.14% 1 in 700 388,571 about 1 in 700 births
348. Dementia 0.14% 1 in 738 368,320 6,175 annual cases in Victora 1996 (DHS-VIC)
349. Intestinal obstruction 0.13% 1 in 746 364,563 6,112 annual cases in Victoria 1996 (DHS-VIC)
350. Burns 0.13% 1 in 754 360,507 6,044 annual cases in Victora 1996 for fires/burns/scalds (DHS-VIC)
351. Ankylosing Spondylitis 0.13% 1 in 775 350,879 129 of every 100,000 people in the US (Mayo Clinic)
352. Type 1 diabetes 0.12% 1 in 800 340,000 1-in-800 (NIAID)
353. Down Syndrome 0.12% 1 in 800 340,000 1-in-800 overall births
354. Genital system cancer 0.12% 1 in 841 323,210 323,210 new cases for genital system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
355. Neural tube defect 0.12% 1 in 864 314,703 11.57 per 10,000 births with neural tube defects in the UK 2002 (University of Ulster, 2003)
356. Shoulder Fracture 0.12% 1 in 867 313,624 5,258 annual cases in Victoria 1996 of clavicle/scapula/humerus (DHS-VIC)
357. Scleroderma 0.11% 1 in 906 300,000 estimated 300,000 Americans (NWHIC)
358. Hip fracture 0.11% 1 in 906 300,000 more than 300,000 hip fractures annually (the number due to osteoporosis)
359. Machinery accidents 0.11% 1 in 942 288,453 4,836 annual cases in Victoria 1996 (DHS-VIC)
360. Kidney Dialysis 0.11% 1 in 946 287,493 287,494 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
361. Natural accidents 0.10% 1 in 958 283,800 4,758 annual cases in Victoria 1996 of natural/environmental factors (DHS-VIC)
362. Triple-X syndrome 0.10% 1 in 1,000 272,000 1 per 1,000 newborn girls suffer from triple X syndrome, Genetics Home Reference website
363. Tourette Syndrome 0.10% 1 in 1,000 272,000 estimated 1-10 per 1,000 children have Tourette syndrome, Genetics Home Reference website
364. Anorexia Nervosa 0.10% 1 in 1,000 272,000 estimated 0.1% adults (USSG); estimated 0.5 to 3.7 percent females (NIMH); 1% of adolescent girls (NWHIC)
365. Wolf-Parkinson-White syndrome 0.10% 1 in 1,000 272,000 1-3 per 1,000 people suffer from Wolff-Parkinson-White syndrome worldwide, Genetics Home Reference website
366. Clubfoot 0.10% 1 in 1,000 272,000 about 1 per 1,000 births3.
367. Noonan Syndrome 0.10% 1 in 1,000 272,000 estimated 1 per 1,000 - 2,500 people are affected by Noonan syndrome, Genetics Home Reference website
368. Ackee Fruit Food poisoning 0.10% 1 in 1,000 272,000 1 per 1000 people in the Caribbean develop ackee fruit poisoning each year
369. Ankle fracture 0.10% 1 in 1,048 259,524 4,351 annual cases in Victoria 1996 (DHS-VIC)
370. Face fracture 0.09% 1 in 1,063 255,826 4,289 annual cases in Victoria 1996 (DHS-VIC)
371. Digestive system cancer 0.09% 1 in 1,063 255,640 255,640 new cases for digestive system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
372. Wrist fracture 0.09% 1 in 1,088 250,000 at least 250,000 wrist fractures (the number caused by osteoporosis annually in the USA)
373. Fractured femur 0.09% 1 in 1,155 235,486 3,948 annual cases in Victoria 1996 (DHS-VIC)
374. Foot fracture 0.08% 1 in 1,240 219,262 3,676 annual cases in Victoria 1996 (DHS-VIC)
375. Fractured Lower Leg 0.08% 1 in 1,304 208,466 3,495 annual cases in Victoria 1996 (DHS-VIC)
376. Breast Cancer 0.08% 1 in 1,326 205,000 205,000 annual cases (SEER 2002 estimate); 180,000 annual cases (NCI); only about 1,000 men
377. Von Hippel-Lindau Disease 0.07% 1 in 1,359 200,000 rare
378. Zollinger-Ellison syndrome 0.07% 1 in 1,359 200,000 rare
379. Lichen sclerosis 0.07% 1 in 1,359 200,000 rare
380. Immune Thrombocytopenic Purpura 0.07% 1 in 1,359 200,000 rare.
381. Behcet's Disease 0.07% 1 in 1,359 200,000 rare in the USA; more common in Middle East, Asia, and Japan.
382. Penile candidiasis 0.07% 1 in 1,359 200,000 rare
383. Ascariasis 0.07% 1 in 1,359 200,000 rare
384. Zellweger Syndrome 0.07% 1 in 1,359 200,000 rare
385. Congenital SMA with arthrogryposis 0.07% 1 in 1,359 200,000 rare
386. Agenesis of the corpus callosum 0.07% 1 in 1,359 200,000 rare
387. Aicardi syndrome 0.07% 1 in 1,359 200,000 rare
388. Empty Sella Syndrome 0.07% 1 in 1,359 200,000 rare
389. Hydranencephaly 0.07% 1 in 1,359 200,000 rare
390. Klippel Feil Syndrome 0.07% 1 in 1,359 200,000 rare
391. Mobius syndrome 0.07% 1 in 1,359 200,000 rare
392. Chediak-Higashi Syndrome 0.07% 1 in 1,359 200,000 rare
393. Machado-Joseph Disease 0.07% 1 in 1,359 200,000 rare
394. Kearns-Sayre Syndrome 0.07% 1 in 1,359 200,000 rare
395. Alpers Syndrome 0.07% 1 in 1,359 200,000 rare
396. Agnosia 0.07% 1 in 1,359 200,000 rare
397. Alexander Syndrome 0.07% 1 in 1,359 200,000 rare
398. Alternating Hemiplegia 0.07% 1 in 1,359 200,000 rare
399. Binswanger's Disease 0.07% 1 in 1,359 200,000 rare
400. Brown-Sequard Syndrome 0.07% 1 in 1,359 200,000 rare
401. Fabry's Disease 0.07% 1 in 1,359 200,000 rare
402. Fahr's Syndrome 0.07% 1 in 1,359 200,000 rare
403. Hallervorden-Spatz disease 0.07% 1 in 1,359 200,000 rare
404. Joubert Syndrome 0.07% 1 in 1,359 200,000 rare
405. Krabbé Disease 0.07% 1 in 1,359 200,000 rare
406. Landau-Kleffner Syndrome 0.07% 1 in 1,359 200,000 rare
407. Microcephaly 0.07% 1 in 1,359 200,000 rare
408. Miller Fisher Syndrome 0.07% 1 in 1,359 200,000 rare
409. Moyamoya Disease 0.07% 1 in 1,359 200,000 rare
410. Parry Romberg Syndrome 0.07% 1 in 1,359 200,000 rare
411. Pelizaeus-Merzbacher Disease 0.07% 1 in 1,359 200,000 rare
412. Primary Lateral Sclerosis 0.07% 1 in 1,359 200,000 rare
413. Progressive Supranuclear Palsy 0.07% 1 in 1,359 200,000 rare
414. Rasmussen's Encephalitis 0.07% 1 in 1,359 200,000 rare
415. Sandhoff Disease 0.07% 1 in 1,359 200,000 rare
416. Schilder's Disease 0.07% 1 in 1,359 200,000 rare
417. Septo-Optic Dysplasia 0.07% 1 in 1,359 200,000 rare
418. Soto's Syndrome 0.07% 1 in 1,359 200,000 rare
419. Stiff-Person Syndrome 0.07% 1 in 1,359 200,000 rare
420. Subacute Sclerosing Panencephalitis 0.07% 1 in 1,359 200,000 rare - because of the rarity of measles due to vaccination programs.
421. Ménétrier's disease 0.07% 1 in 1,359 200,000 rare
422. Goodpasture syndrome 0.07% 1 in 1,359 200,000 rare.
423. Encephaloceles 0.07% 1 in 1,359 200,000 rare
424. Narcolepsy 0.07% 1 in 1,359 200,000 200,000 Americans (NHLBI estimate); 50,000 diagnosed.
425. Mastocytosis 0.07% 1 in 1,359 200,000 rare
426. Cutaneous mastocytosis 0.07% 1 in 1,359 200,000 rare
427. Restrictive cardiomyopathy 0.07% 1 in 1,359 200,000 rare
428. Prostate Cancer 0.07% 1 in 1,439 189,000 189,000 annual cases in USA (SEER 2002 estimate); 168,665 new cases (NIDDK)
429. Respiratory system cancer 0.07% 1 in 1,458 186,550 186,550 new cases for respiratory system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
430. Norwalk-like viruses 0.07% 1 in 1,502 181,000 estimated 181,000 cases annually in USA (CDC-OC)
431. Aortic aneurysm 0.07% 1 in 1,537 176,913 2,966 annual cases in Victoria 1996 (DHS-VIC)
432. Hydrocephalus 0.06% 1 in 1,547 175,711 6.46 per 10,000 births in the UK 2002 for hydrocephaly (University of Ulster, 2003)
433. Lung cancer 0.06% 1 in 1,605 169,400 169,400 annual cases (SEER 2002 estimate: lung and bronchus cancers)
434. Charcot-Marie-Tooth Disorder 0.06% 1 in 1,813 150,000 150,000 people are affected by Charcot-Marie-Tooth disease in the US, Genetics Home Reference website
435. Adult respiratory distress syndrome 0.06% 1 in 1,813 150,000 150,000 adults (NHLBI)
436. Colorectal cancer 0.05% 1 in 1,834 148,300 148,300 annual cases = 107,300 annual cases of colon cancer and 41,000 annual cases of rectum cancer(SEER 2002 estimate)
437. Hepatorenal tyrosinemia 0.05% 1 in 1,845 147,345 1 per 1,846 people from the Saguenay-La St. Jean region of Quebec suffer from tyrosinemia type 1, Genetics Home Reference website
438. Méničre's disease 0.05% 1 in 1,973 137,847 about 10,000 people in Australia
439. Jacobs syndrome 0.05% 1 in 2,000 136,000 1-in-2000 approximately.
440. Keratoconus 0.05% 1 in 2,000 136,000 1-in-2000 Americans
441. Brugada Syndrome 0.05% 1 in 2,000 136,000 estimated 5 per 10,000 people suffer from Brugada syndrome worldwide, Genetic Home Reference website
442. 47 XYY syndrome 0.05% 1 in 2,000 136,000 1 per 1,000 males are born with 47,XYY syndrome, Genetics Home Reference website
443. Gestational diabetes 0.05% 1 in 2,014 135,000 135,000 pregnant women get the condition every year; 3-5% of pregnant women.
444. Chickenpox 0.04% 1 in 2,254 120,624 120,624 annually (1995); 46,016 annual cases notified in USA 1999 (MMWR 1999); 199.14 per 100,000 in Canada 20004
445. Hip Replacement 0.04% 1 in 2,266 120,000 120,000 annually (NIAMS); 120,000 annual hip replacement operations in the USA.
446. Whiplash 0.04% 1 in 2,266 120,000 120,000 annually
447. Turner Syndrome 0.04% 1 in 2,500 108,800 1 per 2,500 live female births are affected by Turner syndrome, Genetics Home Reference website
448. Autoimmune Lymphoproliferative Syndrome 0.04% 1 in 2,719 100,000 very rare; NIAID mentions 58 individuals
449. Neonatal lupus 0.04% 1 in 2,719 100,000 very rare
450. Lyme disease 0.04% 1 in 2,719 100,000 estimated 100,000 cases annually (NIAID/USA)
451. Androgen Insensitivity Syndrome 0.04% 1 in 2,719 100,000 very rare
452. Porencephaly 0.04% 1 in 2,719 100,000 extremely rare
453. Schizencephaly 0.04% 1 in 2,719 100,000 extremely rare
454. Hyperparathyroidism 0.04% 1 in 2,719 100,000 100,000 cases per year in the USA
455. Retinitis Pigmentosa 0.04% 1 in 2,719 100,000 100,000 people have retinitis pigmentosa which can cause retinal deterioration and blindness in the US (Research to Prevent Blindness, NISE, NSF)
456. Urinary system cancer 0.04% 1 in 2,764 98,400 98,400 new cases for urinary system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
457. Septicemia 0.04% 1 in 2,767 98,300 1,648 annual cases in Victora 1996 (DHS-VIC)
458. Accidental death 0.03% 1 in 2,906 93,591 93,592 annual cases in 2000 (CDC); 97,860 annual cases in 1999 (NVSR Sep 2001)
459. Edwards Syndrome 0.03% 1 in 3,000 90,666 1 per 5,000 - 6,000 newborns are affected by Trisomy 18, Genetics Home Reference website
460. Velocardiofacial syndrome 0.03% 1 in 3,000 90,666 1-in-3000 approximately.
461. Fragile-X Syndrome 0.03% 1 in 3,000 90,666 approximately 1 per 8,000 females suffer from fragile X syndrome, Genetics Home Reference website
462. Familial emphysema 0.03% 1 in 3,000 90,666 70,000 Americans
463. Neurofibromatosis-1 0.03% 1 in 3,000 90,666 1 per 3,000 - 4,000 people suffer from neurofibromatosis type 1 worldwide, Genetics Home Reference website
464. Neurofibromatosis 0.03% 1 in 3,000 90,666 about 1 in 30005.
465. Congenital hypothyroidsim 0.03% 1 in 3,000 90,666 1 per 3,000 - 4,000 newborns are affected by congenital hypothyroidsim in North America, Europe, Japan and Australia, Genetics Home Reference website
466. Suffocation 0.03% 1 in 3,285 82,790 1,388 annual cases in Victoria 1996 of suffocation and foreign bodies (DHS-VIC)
467. Vagina cancer 0.03% 1 in 3,333 81,600 3 in 10,000 for DES-related cases of vaginal cancer.
468. Diethylstilbestrol 0.03% 1 in 3,333 81,600 3 per 10,000 with a risk of vaginal cancer; probably higher if include other complications of DES
469. Acute Pancreatitis 0.03% 1 in 3,400 80,000 80,000 cases occur in the USA (NIDDK); 17 per 100,000 new cases
470. Muscular dystrophy, Duchenne and Becker type 0.03% 1 in 3,500 77,714 1 per 3,500 - 5,000 male newborns suffer from muscular dystrophy, Duchenne and Becker types, Genetics Home Reference website
471. Vertebral fracture 0.03% 1 in 3,619 75,155 1,260 annual cases in Victoria 1996 (DHS-VIC)
472. Heroin dependence 0.03% 1 in 3,692 73,664 1,235 annual cases in Victoria 1996 (DHS-VIC)
473. Hereditary sensory and autonomic neuropathy 3 0.03% 1 in 3,700 73,513 estimated 1 per 3,700 people of Ashkenazi Jewish ancestry suffer from familial dysautonomia, Genetics Home Reference website
474. Escherichia coli O157:H7 0.03% 1 in 3,726 73,000 estimated 73,000 annual cases of infection in USA (DBMD)
475. Cannabis dependence 0.03% 1 in 3,759 72,351 1,213 annual cases in Victoria 1996 (DHS-VIC)
476. Sedative dependence 0.03% 1 in 3,759 72,351 1,213 annual cases in Victoria 1996 (DHS-VIC)
477. Syphilis 0.03% 1 in 3,885 70,000 70,000 cases (NIAID; CDC 2001)
478. Ectopic pregnancy 0.03% 1 in 3,885 70,000 70,000 cases annually; about 1 in 250 pregnancies.
479. Hepatitis D 0.03% 1 in 3,885 70,000 70,000 new cases in the USA 1990 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
480. Congenital hypothyroidism 0.03% 1 in 4,000 68,000 about 1 in 4000 babies
481. Chromosome 22q11.2 deletion syndrome 0.03% 1 in 4,000 68,000 estimated 1 per 4,000 newborns are affected by chromosome 22q11.2 deletion syndrome, Genetics Home Reference website
482. Diabetic Retinopathy 0.02% 1 in 4,184 65,000 65,000 diabetics develop proliferative retinopathy, the most sight-threatening stage in the US (Research to Prevent Blindness, NISE, NSF)
483. Holoprosencephaly 0.02% 1 in 4,201 64,736 2.38 per 10,000 births in the UK 2002 for arhinencephaly/holprosencephaly (University of Ulster, 2003)
484. Multiple Myeloma 0.02% 1 in 4,317 63,000 about 63,000 people affected by multiple myeloma ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
485. Primary Glomerulonephritis 0.02% 1 in 4,428 61,422 61,423 people with Primary Glomerulonephritis in the USA 1996 2
486. IgA nephropathy 0.02% 1 in 4,428 61,422 61,423 people in the USA 1996 2
487. Lymphoma 0.02% 1 in 4,466 60,900 60,900 annual cases in USA (SEER 2002 estimate)
488. Pelvic fracture 0.02% 1 in 4,475 60,780 1,019 annual cases in Victoria 1996 (DHS-VIC)
489. Bladder Cancer 0.02% 1 in 4,814 56,500 bladder cancer is the fourth most common type of cancer in men in the US, Genetics Home Reference website
490. Patau syndrome 0.02% 1 in 5,000 54,400 1-in-5000 approximately.
491. Sarcoidosis 0.02% 1 in 5,000 54,400 20 per 100,000 overall; 5 in 100,000 white people; 40 out of 100,000 black people; Scandinavia 64 out of 100,000 people
492. Aortic coarctation 0.02% 1 in 5,000 54,400 1 in 5000 babies
493. Marfan syndrome 0.02% 1 in 5,000 54,400 1 per 5,000 people are affected by Marfan syndrome worldwide, Genetics Home Reference website
494. Alpha 1-Antitrypsin Deficiency 0.02% 1 in 5,000 54,400 1 per 5,000 - 7,000 people suffer from alpha-1 antitrypsin deficiency in North America, Genetics Home Reference website
495. Hereditary hemorrhagic telangiectasia 0.02% 1 in 5,000 54,400 estimated 1 per 5,000 - 10,000 people suffer from hereditary hemorrhagic telangiectasia worldwide, Genetics Home Reference website
496. Non-Hodgkin's Lymphoma 0.02% 1 in 5,046 53,900 53,900 annual cases in USA (SEER 2002 estimate)
497. Melanoma 0.02% 1 in 5,074 53,600 53,600 annual cases (SEER 2002 estimate: skin melanomas)
498. Cardiomyopathy 0.02% 1 in 5,439 50,000 50,000 Americans (NHLBI)
499. Pancreatitis 0.02% 1 in 5,882 46,240 17 new cases per 100,000 in the USA 1976-88 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
500. Duchenne Muscular Dystrophy 0.02% 1 in 6,000 45,333 about 1 in 3000 males5.
501. Spinal Muscular Atrophy 0.02% 1 in 6,000 45,333 1 per 6,000 - 10,000 people suffer from spinal muscular atrophy, Genetics Home Reference website
502. Dentinogenesis 0.02% 1 in 6,000 45,333 estimated 1 per 6,000 - 8,000 people suffer from dentinogenesis imperfecta, Genetics Home Reference website
503. Giardia 0.02% 1 in 6,138 44,308 16.29 per 100,000 in Canada 20004
504. Canavan disease 0.02% 1 in 6,400 42,500 1 per 6,400 - 13,500 people of Ashkenazi Jewish heritage suffer from Canavan disease, Genetics Home Reference website
505. Skull fracture 0.02% 1 in 6,413 42,409 711 annual cases in Victoria 1996 (DHS-VIC)
506. Diabetes Insipidus 0.01% 1 in 6,666 40,800 less than 15 per 100,000 hospitalized patients
507. Coccidioidomycosis 0.01% 1 in 6,666 40,800 15 cases per 100,000 population in Arizona in 1995 (DBMD)
508. Rectal cancer 0.01% 1 in 6,704 40,569 40,570 new cases for rectum cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
509. Bell's Palsy 0.01% 1 in 6,800 40,000 40,000 annual cases in Americans
510. Neonatal Respiratory Distress Syndrome 0.01% 1 in 6,800 40,000 40,000 infants and 150,000 adults with adult RDS (NHLBI)
511. Endometrial Cancer 0.01% 1 in 6,921 39,300 39,300 annual cases in USA (SEER 2002 estimate)
512. Romano-Ward syndrome 0.01% 1 in 7,000 38,857 estimated 1 per 7,000 people suffer from Romano-Ward syndrome worldwide, Genetics Home Reference website
513. Prolactinoma 0.01% 1 in 7,142 38,080 less than 14 per 100,000 (the rate for pituitary tumors)
514. Pituitary Cancer 0.01% 1 in 7,142 38,080 14 per 100,000 people (NIDDK)
515. Williams Syndrome 0.01% 1 in 7,500 36,266 estimated 1 per 7,500 - 20,000 people suffer from Williams syndrome, Genetics Home Reference website
516. Stickler Syndrome 0.01% 1 in 7,500 36,266 estimated 1 per 7,500 - 9,000 newborns suffer from Stickler syndrome, Genetics Home Reference website
517. Hepatitis A 0.01% 1 in 8,500 32,000 32,000 new cases in the USA 1992 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
518. Kidney Cancer 0.01% 1 in 8,553 31,800 31,800 annual cases in USA (SEER 2002 estimate); more than 28,000 cases annually in the United States
519. Leukemia 0.01% 1 in 8,831 30,800 30,800 annual cases in USA (SEER 2002 estimate) including 10,800 lymphocytic, 15,000 myeloid and 5,000 other leukemias; about 29,000 cases annually (NCI); nearly 27,000 adults and more than 2,000 children annually.
520. Pancreatic cancer 0.01% 1 in 8,976 30,300 30,300 annual cases (SEER 2002 estimate)
521. Suicide 0.01% 1 in 9,315 29,200 29,199 annual cases of actual suicide in 1999 USA (NVHS Sep 2001)
522. Oral cancer 0.01% 1 in 9,411 28,900 28,900 annual cases (SEER 2002 estimate)
523. Firearm Injury 0.01% 1 in 9,420 28,873 28,874 annual cases causing death in 1999 USA (NVSR Sep 2001)
524. Tuberous sclerosis 0.01% 1 in 10,000 27,200 less than 1 in 10,000
525. Autoimmune Thrombocytopenia 0.01% 1 in 10,000 27,200 less than 10 per 100,000 cases and 1-4 per 100,000 in children2
526. Prader-Willi syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 25,000 people suffer from Prader-Willi syndrome, Genetics Home Reference website
527. Phenylketonuria 0.01% 1 in 10,000 27,200 1 per 10,000 - 15,000 newborns are diagnosed with phenylketonuria in the US, Genetics Home Reference website
528. Rett's syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 22,000 females suffer from Rett syndrome, Genetics Home Reference website
529. Osteogenesis imperfecta 0.01% 1 in 10,000 27,200 6-7 per 100,000 people are affected by osteogenesis imperfecta worldwide, Genetics Home Reference website
530. Cornelia de Lange Syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 30,000 newborns suffer from Cornelia de Lange syndrome, Genetics Home Reference website
531. Cystinuria 0.01% 1 in 10,000 27,200 approximately 1 per 10,000 people are affected by cystinuria, Genetics Home Reference website
532. Chromosome 13 trisomy syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 newborns are affected by Trisomy 13, Genetics Home Reference website
533. Congenital myopathy 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 people from Scandinavia suffer from myotonia congenita worldwide, Genetics Home Reference website
534. Blue-yellow color vision defects 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 people suffer from blue-yellow color vision defects worldwide, Genetics Home Reference website
535. 2-methylglutaconic aciduria type 3 0.01% 1 in 10,000 27,200 1 per 10,000 newborns from Iraqi Jewish populations suffer from 2-methylglutaconic aciduria type 3, Genetics Home Reference website
536. Waardenburg syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 20,000 people suffer from Waardenburg syndrome, Genetics Home Reference website
537. Endocrine system cancer 0.01% 1 in 10,658 25,520 25,520 new cases for endocrine system cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
538. E-coli food poisoning 0.01% 1 in 10,879 25,000 25,000 cases per year estimated
539. Meningitis 0.01% 1 in 10,879 25,000 approximately 25,000 cases of bacterial meningitis annually in USA; 206 annual cases in Victoria 1996 (DHS-VIC)
540. Fetal alcohol syndrome 0.01% 1 in 11,111 24,479 0.9 per 10,000 births (Caucasians); Asians 0.3, Hispanics 0.8, African Americans 6.0, and Native Americans 29.9 (NWHIC).
541. Amputated thumb 0.01% 1 in 11,573 23,500 394 annual cases in Victoria 1996 (DHS-VIC)
542. Ovarian Cancer 0.01% 1 in 11,673 23,300 23,300 annual cases in USA (SEER 2002 estimate); about 1 in 57 women in the United States (NCI)
543. Angelman syndrome 0.01% 1 in 12,000 22,666 1 per 12,000 - 20,000 people are affected by Angelman syndrome, Genetics Home Reference website
544. Invasive candidiasis 0.01% 1 in 12,500 21,760 8 per 100,000 for candidemia (DBMD)
545. Adrenal hypoplasia congenital, X-linked 0.01% 1 in 12,500 21,760 1 per 12,500 newborns suffer from adrenal hypoplasia congenita in the US, Genetics Home Reference website
546. Stomach cancer 0.01% 1 in 12,592 21,600 21,600 annual cases (SEER 2002 estimate); about 24,000 annual cases in the United States (NCI)
547. Amputated finger 0.01% 1 in 13,066 20,816 349 annual cases in Victoria 1996 (DHS-VIC)
548. Thyroid cancer 0.01% 1 in 13,140 20,700 20,700 annual cases in USA (SEER 2002 estimate); 19,500 annual cases in the USA (NCI); 14,900 women and 4,600 men annually (NCI).
549. Brain tumor, adult 0.01% 1 in 13,268 20,500 estimated 20,500 new cases of brain cancer will be diagnosed in the US in 2007, National Cancer Institute website
550. Uterine Cancer 0.01% 1 in 13,333 20,400 4,500 women in the UK 2001 (National Statistics, UK Government Census, 2001)
551. Ross River virus 0.01% 1 in 13,513 20,128 7.4 new cases per 100,000 population of Ross River Virus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
552. Hemophilia 0.01% 1 in 13,600 20,000 20,000 people in the United States (NHLBI)
553. Placenta previa 0.01% 1 in 13,600 20,000 1 in 200 pregnancies (FMC)
554. Amelogenesis Imperfecta 0.01% 1 in 14,000 19,428 estimated 1 per 14,000 people suffer from amelogenesis imperfecta in the US, Genetics Home Reference website
555. Coffin-Lowry syndrome 0.01% 1 in 14,285 19,040 estimated 7 per 100,000 people have Coffin-Lowry syndrome in western Europe and North America, Genetics Home Reference website
556. Transplants 0.01% 1 in 14,315 19,000 more than 19,000 transplants annually in USA (NIAID)
557. Group B Streptococcal Infections 0.01% 1 in 14,492 18,767 6.9 cases per 100,000 (DBMD)
558. Tuberculosis 0.01% 1 in 14,814 18,360 18,361 cases annually in the USA (1998); 8 million people worldwide develop active TB and 3 million die; 17,531 annual cases notified in USA 1999 (MMWR 1999); 5.50 per 100,000 in Canada 20004
559. Smith-Magenis Syndrome 0.01% 1 in 15,000 18,133 1 per 15,000 undiagnosed and diagnosed people are affected by Smith-Magenis syndrome worldwide , Genetics Home Reference website
560. Hypochondroplasia 0.01% 1 in 15,000 18,133 estimated 1 per 15,000 - 40,000 newborns suffer from hypochondroplasia, Genetics Home Reference website
561. Rabies 0.01% 1 in 15,111 18,000 18,000 cases (of rabies shots rather than actual rabies)
562. Shigellosis 0.01% 1 in 15,524 17,521 17,521 annual cases of shigellosis notified in USA 1999 (MMWR 1999)
563. Brain cancer 0.01% 1 in 16,000 17,000 17,000 annual cases in USA (SEER 2002 estimate: brain and other nervous system)
564. Homicide 0.01% 1 in 16,105 16,889 16,889 annual cases in 1999 including 10,828 for firearms (NVSR Sep 2001)
565. Liver cancer 0.01% 1 in 16,385 16,600 16,600 annual cases (SEER 2002 estimate)
566. Spina bifida 0.01% 1 in 16,666 16,320 6 per 100,000 births
567. Usher Syndrome 0.01% 1 in 17,000 16,000 16,000 Americans
568. Medium-Chain Acyl-CoA Dehydrogenase Deficiency 0.01% 1 in 17,000 16,000 1 per 17,000 people suffer from medium-chain acyl-CoA dehydrogenase deficiency in the US, Genetics Home Reference website
569. Kidney transplant 0.01% 1 in 17,741 15,331 15,331 procedures in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
570. Alkaptonuria 0.01% 1 in 19,000 14,315 1 per 19,000 people suffer from alkaptonuria in parts of Slovakia, Genetics Home Reference website
571. Myelodysplastic syndromes 0.01% 1 in 19,428 14,000 14,000 people are diagnosed with myelodysplastic syndrome each year in the US (American Cancer Society, Medical News Today)
572. Myasthenia Gravis 0.00% 1 in 20,000 13,600 about 5 per 100,000 to 14 per 100,000 (NWHIC)
573. Adrenoleukodystrophy 0.00% 1 in 20,000 13,600 1 per 20,000 people suffer from X-linked adrenoleukodystrophy, Genetics Home reference website
574. Autosomal Recessive Polycystic Kidney Disease 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 people suffer from the autosomal recessive type of polycystic kidney disease, Genetics Home Reference website
575. Werner syndrome 0.00% 1 in 20,000 13,600 1 per 20,000 - 40,000 people suffer from Werner syndrome in Japan, Genetics Home Reference website
576. Smith-Lemli-Opitz Syndrome 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 newborns suffer from Smith-Lemli-Opitz syndrome, Genetics Home Reference website
577. Alagille Syndrome 0.00% 1 in 20,000 13,600 1 per 20,000 - 70,000 people suffer from Alagille syndrome, Genetics Home Reference website
578. Polycystic kidney disease type 1 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 people are affected by autosomal dominant polycystic kidney disease, Genetics Home Reference website
579. Oculocutaneous albinism 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 people suffer from oculocutaneous albinism, Genetic Home Reference website
580. Thanatophoric dysplasia 0.00% 1 in 20,000 13,600 1 per 20,000 - 50,000 newborns are affected by Thanatophoric dysplasia, Genetics Home Reference website
581. Dermatomyositis 0.00% 1 in 20,205 13,461 13,462 people with polymyositis/dermatomyositis in the USA 1996 2
582. Cervical Cancer 0.00% 1 in 20,923 13,000 13,000 annual cases in USA (SEER 2002 estimate)
583. Barmah Forest virus 0.00% 1 in 21,739 12,512 4.6 new cases per 100,000 population of Barmah Forest Virus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
584. Larynx Cancer 0.00% 1 in 22,666 12,000 12,000 annual cases in the United States (NCI); 8,900 annual cases (SEER 2002 estimate)
585. Acute myeloid leukemia 0.00% 1 in 22,818 11,919 11,920 new cases for Acute Myeloid Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
586. Rheumatic heart disease 0.00% 1 in 23,505 11,571 194 annual cases in Victoria 1996 (DHS-VIC)
587. Acromegaly 0.00% 1 in 25,000 10,880 40-60 per million affected people at any time
588. Pseudoxanthoma elasticum 0.00% 1 in 25,000 10,880 1 per 25,000 - 100,000 people are affected by pseudoxanthoma elasticum, Genetics Home Reference website
589. Neurofibromatosis-2 0.00% 1 in 25,000 10,880 1 per 25,000 people suffer from neurofibromatosis type 2, Genetics Home Reference website
590. Usher Syndrome Type 1 0.00% 1 in 25,000 10,880 more than 4 per 100,000 people suffer from Usher syndrome type I, Genetics Home Reference website
591. Q fever 0.00% 1 in 25,641 10,608 3.9 new cases per 100,000 population of Q Fever were notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
592. Cystinosis 0.00% 1 in 26,000 10,461 1 per 26,000 newborns suffer from cystinosis in the Brittany province in France, Genetics Home Reference website
593. Mouth cancer 0.00% 1 in 26,984 10,080 10,080 new cases for mouth cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
594. Toxocariasis 0.00% 1 in 27,200 10,000 estimated 10,000 annual cases in USA (DPD)
595. Avascular necrosis 0.00% 1 in 27,200 10,000 10,000 to 20,000 annual cases (NIAMS)
596. Primary biliary cirrhosis 0.00% 1 in 29,462 9,231 9,232 people in the USA 1996 2
597. Wilson's Disease 0.00% 1 in 30,000 9,066 approximately 1 per 30,000 people suffer from Wilson disease, Genetics Home Reference website
598. Muenke Syndrome 0.00% 1 in 30,000 9,066 estimated 1 per 30,000 newborns suffer from Muenke syndrome, Genetics Home Reference website
599. Galactosemia I 0.00% 1 in 30,000 9,066 1 per 30,000 liver births are affected by inherited galactosemia, Genetics Home Reference website
600. Achromatopsia type 1 0.00% 1 in 30,000 9,066 estimated 1 per 30,000 people suffer from complete achromatopsia, Genetics Home Reference website
601. Familial polyposis, autosomal recessive 0.00% 1 in 30,000 9,066 1 per 30,000 people are affected by familial adenomatous polyposis in the US, Genetics Home Reference website
602. Leber hereditary optic neuropathy 0.00% 1 in 30,000 9,066 1 per 30,000 - 50,000 people suffer from Leber hereditary optic neuropathy in northeast England and Finland, Genetics Home Reference website
603. Viral meningitis 0.00% 1 in 30,452 8,932 8,932 new cases in America 1995 (Meningitis Foundation of America, CDC, 1994)
604. Cystic Fibrosis 0.00% 1 in 31,000 8,774 1 per 31,000 Asian American newborns suffer from cystic fibrosis in the US, genetics Home Reference website
605. Group A Streptococcal Infections 0.00% 1 in 31,249 8,704 3.2 cases per 100,000 (DBMD)
606. Soft Tissue Sarcoma 0.00% 1 in 32,771 8,300 8,300 annual cases (SEER 2002 estimate)
607. Pharynx cancer 0.00% 1 in 32,969 8,250 8,250 new cases for pharynx cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
608. Chronic lymphocytic leukemia 0.00% 1 in 33,211 8,190 8,190 new cases for Chronic Lymphocytic Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
609. Huntington's Disease 0.00% 1 in 33,333 8,160 estimated 3-7 per 100,000 people of European ancestry suffer from Huntington disease, Genetics Home Reference website
610. Colonic volvulus 0.00% 1 in 33,333 8,160 3 per 100,000 persons per year
611. Multiple endocrine neoplasia type 1 0.00% 1 in 33,333 8,160 3 per 100,000 up to 20 per 100,000 (NIDDK)
612. Osteogenesis imperfecta Type I 0.00% 1 in 33,333 8,160 3-4 per 100,000 people are affected by osteogenesis imperfecta type I worldwide, Genetics Home Reference website
613. Osteogenesis imperfecta type IV 0.00% 1 in 33,333 8,160 3-4 per 100,000 people are affected by osteogenesis imperfecta type IV worldwide, Genetics Home Reference website
614. Testicular Cancer 0.00% 1 in 36,266 7,500 7,500 annual cases in USA (SEER 2002 estimate)
615. Whooping Cough 0.00% 1 in 36,731 7,405 7,405 cases annually in USA (1998); under-diagnosis of cases in adults means the real prevalence may be much higher
616. Tongue Cancer 0.00% 1 in 37,158 7,320 7,320 new cases for tongue cancer in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
617. Gall Bladder Cancer 0.00% 1 in 38,309 7,100 7,100 annual cases (SEER 2002 estimate: gallbladder and other biliary)
618. Hodgkin's Disease 0.00% 1 in 38,857 7,000 7,000 annual cases in USA (SEER 2002 estimate); less than 1 percent of all cases of cancer
619. Ataxia Telangiectasia 0.00% 1 in 40,000 6,800 1 per 40,000 - 100,000 people worldwide suffer from ataxia-telangiectasia, Genetics Home Reference website
620. Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 - 120,000 people suffer from very long-chain acyl-CoA dehydrogenase deficiency, Genetics Home Reference website
621. Short-Chain Acyl-CoA Dehydrogenase Deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 - 100, 000 newborns suffer from short-chain acyl-CoA dehydrogenase deficiency in the US, Genetics Home Reference website
622. Pompe disease 0.00% 1 in 40,000 6,800 1 per 40,000 people suffer from Pompe disease, Genetics Home Reference website
623. Carnitine transporter deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 newborns suffer from primary carnitine deficiency in Japan, Genetics Home Reference website
624. Achondrogenesis 0.00% 1 in 40,000 6,800 1 per 40,000 - 60,000 people are affected by achondrogenesis type 2 and hypochondrogenesis, Genetics Home Reference website
625. Niemann-Pick disease, type A 0.00% 1 in 40,000 6,800 approximately 1 per 40,000 people of Ashkenazi Jewish descent have Niemann-Pick disease type A, Genetics Home Reference website
626. Friedreich ataxia 0.00% 1 in 40,000 6,800 estimated 1 per 40,000 people are affected by Friedreich ataxia, Genetics Home Reference website
627. Infant Cytomegalic virus 0.00% 1 in 45,333 6,000 6,000 babies
628. Bloom Syndrome 0.00% 1 in 48,000 5,666 1 per 48,000 people of Ashkenazi Jewish descent suffer from Bloom syndrome, Genetics Home Reference website
629. Small intestine cancer, adult 0.00% 1 in 48,226 5,639 estimated 5,640 new cases of small intestine cancer will be diagnosed in the US in 2007, National Cancer Institute website
630. Motor neuron diseases 0.00% 1 in 49,566 5,487 92 annual cases in Victoria 1996 (DHS-VIC)
631. Gaucher Disease 0.00% 1 in 50,000 5,440 1 per 50,000 - 100,000 people are affected by Gaucher disease, Genetics Home Reference website
632. Alport Syndrome 0.00% 1 in 50,000 5,440 1 per 50,000 newborns suffer from Alport syndrome, Genetics Home Reference website
633. Treacher-Collins Syndrome 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 people suffer from Treacher Collins syndrome, Genetics Home Reference website
634. Acidemia, methylmalonic 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 - 100,000 suffer from Methylmalonic acidemia, Genetics Home Reference website
635. 3-methylcrotonyl-CoA carboxylase deficiency 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 people suffer from 3-methylcrotonyl-CoA carboxylase deficiency, Genetics Home Reference website
636. Severe combined immunodeficiency, X-linked 0.00% 1 in 50,000 5,440 1 per 50,000 - 100,000 births are affected by X-linked severe combined immunodeficiency, Genetics Home Reference website
637. Hereditary neuropathy with liability to pressure palsies 0.00% 1 in 50,000 5,440 2-5 per 100,000 people suffer from hereditary neuropathy with liability to pressure palsies, Genetics Home Reference website
638. Small Intestine Cancer 0.00% 1 in 51,320 5,300 5,300 annual cases (SEER 2002 estimate)
639. Amyotrophic lateral sclerosis 0.00% 1 in 54,400 5,000 4-8 per 1000,000 people suffer from amyotrophic lateral sclerosis worldwide, Genetics Home Reference website
640. Bronchopulmonary dysplasia 0.00% 1 in 54,400 5,000 5,000 to 10,000 new cases
641. Brainerd diarrhea 0.00% 1 in 54,400 5,000 estimated 5,000-8,000 patients (DBMD)
642. Citrullinemia I 0.00% 1 in 57,000 4,771 1 per 57,000 people have citrullinemia I worldwide , Genetics Home Reference website
643. Reiter’s syndrome 0.00% 1 in 57,142 4,760 3.5 per 100,000 men under age 50 get Reiter’s syndrome each year
644. Anal Cancer 0.00% 1 in 58,494 4,649 estimated 4,650 new cases of anal cancer will be diagnosed in the US in 2007, National Cancer Institute website
645. Autoimmune uveitis 0.00% 1 in 58,658 4,637 4,637 people in the USA 1996 2
646. Chronic myeloid leukemia 0.00% 1 in 59,130 4,600 4,600 new cases for Chronic Myeloid Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
647. Biotinidase deficiency 0.00% 1 in 60,000 4,533 about 1 per 60,000 newborns suffer from profound or partial biotinidase deficiency, Genetics Home Reference website
648. Oxalosis, type I 0.00% 1 in 60,000 4,533 estimated 1 per 60,000 - 120,000 births are affected by primary hyperoxaluria, type I, Genetics Home Reference website
649. Ellis-van Creveld syndrome 0.00% 1 in 60,000 4,533 1 per 60,000 - 200,000 newborns are affected by Ellis-van Creveld syndrome worldwide, Genetics Home Reference website
650. Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency 0.00% 1 in 62,000 4,387 estimated 1 per 62,000 people suffer from long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency in Finland, Genetics Home Reference website
651. Corneal Dystrophies 0.00% 1 in 64,761 4,200 4,200 people have reduced vision because of corneal dystrophies in the US (Research to Prevent Blindness, NISE, NSF)
652. Anencephaly 0.00% 1 in 68,000 4,000 less than 4,000 cases (the rate for spina bifida and anencephaly, NWHIC)
653. Acute lymphocytic leukemia 0.00% 1 in 71,018 3,830 3,830 new cases for Acute Lymphocytic Leukemia in the US 2004 (Cancer Facts and Figures, American Cancer Society, 2004)
654. Vulva cancer 0.00% 1 in 71,578 3,800 3,800 annual cases in USA (SEER 2002 estimate)
655. Vulvar cancer 0.00% 1 in 77,936 3,489 estimated 3,490 new cases of vulvar cancer will be diagnosed in the US in 2007, National Cancer Institute website
656. Autoimmune Hemolytic Anemia 0.00% 1 in 80,000 3,400 1 per 80,000 cases to 2.6 per 100,000 (as reported in Rose and Mackay 19986)
657. Ornithine transcarbamylase (OTC) Deficiency 0.00% 1 in 80,000 3,400 estimated 1 per 80,000 people suffer fro ornithine transcarbamylase deficiency, Genetics Home Reference website
658. Holocarboxylase synthetase deficiency 0.00% 1 in 87,000 3,126 estimated 1 per 87,000 people are affected by holocarboxylase synthetase deficiency, Genetics Home Reference website
659. Amyloidosis 0.00% 1 in 90,666 3,000 less than 3,000 people in the US (Mayo Clinic)
660. Addison's Disease 0.00% 1 in 100,000 2,720 1 in 100,000; 13,335 people in the USA 1996 2
661. Guillain-Barre Syndrome 0.00% 1 in 100,000 2,720 about 1 in 100,000 (NWHIC)
662. Mycobacterium avium Complex 0.00% 1 in 100,000 2,720 1 per 100,000 annually (DBMD)
663. Aspergillosis 0.00% 1 in 100,000 2,720 1-2 per 100,000 per year (DBMD)
664. X-Linked Agammaglobulinemia 0.00% 1 in 100,000 2,720 1-in-100,000
665. Menkes Disease 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer Menkes syndrome, Genetics Home Reference website
666. Hypokalemic periodic paralysis 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from hypokalemic periodic paralysis, Genetics Home Reference website
667. Yersiniosis 0.00% 1 in 100,000 2,720 approx 1 per 100,000 annually (DBMD); 19 cases in NJ 1998 (NJ DHSS)
668. Pneumococcal meningitis 0.00% 1 in 100,000 2,720 about 1 to 2 per 100,000 in the USA
669. Cushing's syndrome 0.00% 1 in 100,000 2,720 2-5 per million (NIDCD); 10 per million; 10-15 per million
670. Drowning 0.00% 1 in 100,000 2,720 1 per 100,000 population drowns in Australia 2002 (Australia’s Health 2004, AIHW)
671. Apert syndrome 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from Apert syndrome, Genetics Home Reference website
672. Pfeiffer syndrome 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from Pfeiffer syndrome, Genetics Home Reference website
673. Blastomycosis 0.00% 1 in 100,000 2,720 1-2 cases per 100,000 (DBMD)
674. Rubinstein-Taybi Syndrome 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 - 125,000 newborns suffer from Rubinstein-Taybi syndrome, Genetics Home Reference website
675. Holt-Oram Syndrome 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer from Holt-Oram disease, Genetics Home Reference website
676. Diastrophic dysplasia 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 newborns are affected by diastrophic dysplasia, Genetics Home Reference website
677. Krabbe leukodystrophy 0.00% 1 in 100,000 2,720 1 per 100,000 people are affected by Krabbe disease in the US, Genetics Home Reference website
678. Gaucher disease type 3 0.00% 1 in 100,000 2,720 less than 1 per 100,000 births are affected by Gaucher disease type 3, Genetics Home Reference website
679. Emery-Dreifuss muscular dystrophy, X-linked 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer from X-linked Emery-Dreifuss muscular dystrophy, Genetics Home Reference website
680. Citrullinemia II 0.00% 1 in 100,000 2,720 1 per 100,000 - 230,000 people have citrullinemia II in Japan , Genetics Home Reference website
681. Paramyotonia congenita 0.00% 1 in 100,000 2,720 less than 1 per 100,000 people are affected by paramyotonia congenital, Genetics Home Reference website
682. Porphyria cutanea tarda, familial type 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by porphyria cutanea tarda, Genetics Home Reference website
683. Osteogenesis imperfecta type IIII 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by osteogenesis imperfecta type IIII worldwide, Genetics Home Reference website
684. Osteogenesis imperfecta type II 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by osteogenesis imperfecta type II worldwide, Genetics Home Reference website
685. Klinefelter syndrome variant 0.00% 1 in 100,000 2,720 1 per 50,000 males are affected by Klinefelter syndrome variants, Genetics Home Reference website
686. Propionic academia 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 live births suffer from propionic academia in the US, Genetics Home Reference website
687. Infant Death 0.00% 1 in 102,719 2,648 2,648 annual cases (NVSR Sep 2001); 7.1 per 1,000 infant deaths (per births) in USA 1999 (NVSR Sep 2001)
688. Meningococcal disease 0.00% 1 in 108,756 2,500 2,501 annual cases notified in USA 1999 (MMWR 1999)
689. Listeriosis 0.00% 1 in 108,800 2,500 estimated 2,500 annually in USA (DBMD)
690. Amputated toe 0.00% 1 in 111,223 2,445 41 annual cases in Victoria 1996 (DHS-VIC)
691. Bone cancer 0.00% 1 in 113,333 2,400 2,400 annual cases (SEER 2002 estimate: bones and joints)
692. Ureter cancer 0.00% 1 in 113,333 2,400 2,400 annual cases in USA (SEER 2002 estimate)
693. Invasive group A Streptococcal disease 0.00% 1 in 114,189 2,382 2,382 annual cases notified in USA 1999 (MMWR 1999); 1.95 per 100,000 in Canada 20004
694. Cryptosporiosis 0.00% 1 in 115,205 2,360 2,361 annual cases notified in USA 1999 (MMWR 1999)
695. Eye cancer 0.00% 1 in 123,636 2,200 2,200 annual cases (SEER 2002 estimate: eye and orbit)
696. Niemann-Pick disease, type C2 0.00% 1 in 150,000 1,813 approximately 1 per 150,000 people have Niemann-Pick disease type C, Genetics Home Reference website
697. Amebiasis 0.00% 1 in 150,800 1,803 54 cases in NJ 1998 (NJ DHSS)
698. Malaria 0.00% 1 in 151,111 1,800 1,800 cases annually (1997); 1,666 annual cases notified in USA 1999 (MMWR 1999)
699. Cryptococcal Meningitis 0.00% 1 in 200,000 1,360 about 5 per million
700. Cri-du-chat syndrome 0.00% 1 in 200,000 1,360 1 per 200,000-500,000 newborns are affected by Cri-du-chat syndrome, Genetics Home Reference website
701. Hyperkalemic periodic paralysis 0.00% 1 in 200,000 1,360 1 per 200,000 people are affected by hyperkalemic periodic paralysis, Genetics Home Reference website
702. Unexplained Illness 0.00% 1 in 200,000 1,360 At least 0.5 cases per 100,000 (DBMD)
703. Homocystinuria 0.00% 1 in 200,000 1,360 at least 1 per 200,000 - 335,000 people are affected by homocystinuria worldwide, Genetics Home Reference website
704. Jervell and Lange-Nielsen Syndrome 0.00% 1 in 200,000 1,360 at least 1 per 200,00 people suffer from Jervell and Lange-Nielsen syndrome in Denmark, Genetics Home Reference website
705. Cowden's syndrome 0.00% 1 in 200,000 1,360 estimated 1 per 200,000 people are affected by Cowden's syndrome, Genetic Home Reference website
706. Penis Cancer 0.00% 1 in 226,666 1,200 1,200 annual cases in USA (SEER 2002 estimate)
707. Autoimmune Hepatitis 0.00% 1 in 235,294 1,156 1,156 people in the USA 1996 2
708. Legionnaires' disease 0.00% 1 in 245,487 1,107 1,108 annual cases notified in USA 1999 (MMWR 1999)
709. Ehlers-Danlos syndrome 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 people suffer from the vascular type of Ehlers-Danlos syndrome, Genetics Home Reference website
710. Peutz-Jeghers Syndrome 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 - 300,000 people suffer from Peutz-Jeghers syndrome, Genetics Home Reference website
711. Oculocutaneous tyrosinemia 0.00% 1 in 250,000 1,087 1 per 250,000 people suffer from tyrosinemia type 2, Genetics Home Reference website
712. Pyruvate carboxylase deficiency 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 births are affected by pyruvate carboxylase deficiency, Genetics Home Reference website
713. Isovaleric academia 0.00% 1 in 250,000 1,087 1 per 250,000 births are affected by isovaleric academia in the US, Genetics Home Reference website
714. Kawasaki disease 0.00% 1 in 271,440 1,002 30 cases in NJ 1998 (NJ DHSS)
715. Thalassemia 0.00% 1 in 272,000 1,000 1,000 people with Cooley's anemia (NHLBI)
716. Secondary pulmonary hypertension 0.00% 1 in 272,000 1,000 about 1,000 new cases of pulmonary arterial hypertension are diagnosed each year in the US, Genetics Home Reference website
717. Arginase deficiency 0.00% 1 in 300,000 906 estimated 1 per 300,000 - 1,000,000 people suffer from arginase deficiency, Genetics Home Reference website
718. Lesch-Nyhan syndrome 0.00% 1 in 380,000 715 1 per 380,000 people are affected by Lesch-Nyhan syndrome worldwide, Genetics Home Reference website
719. Incontinentia Pigmenti 0.00% 1 in 388,571 700 700 - 1,000 cases of incontinentia pigmenti have been reported, Genetics Home Reference website
720. Vibrio parahaemolyticus 0.00% 1 in 400,000 680 0.25 per 100,000 (DBMD 1997)
721. Barth Syndrome 0.00% 1 in 400,000 680 1 per 200,000 male infants suffer from 2-methylglutaconic aciduria type 2, Genetics Home Reference website
722. Necrotizing fasciitis 0.00% 1 in 453,333 600 600 cases (DBMD)
723. Rocky Mountain spotted fever 0.00% 1 in 469,775 578 579 annual cases notified in USA 1999 (MMWR 1999)
724. Congenital syphilis 0.00% 1 in 489,208 556 556 annual cases notified in USA 1999 (MMWR 1999)
725. Cryptococcosis 0.00% 1 in 500,000 544 0.2-0.9 cases per 100,000 in the general population (DBMD)
726. SCID 0.00% 1 in 500,000 543 approximately 1-per-500,000 (NIDCD); 1-per-million
727. Gaucher disease type 2 0.00% 1 in 500,000 543 less than 1 per 500,000 births are affected by Gaucher disease type 2, Genetics Home Reference website
728. Amputated arm 0.00% 1 in 506,683 536 9 annual cases in Victoria 1996 (DHS-VIC)
729. Muscular Dystrophy 0.00% 1 in 544,000 500 500 - 600 male newborns are diagnosed with muscular dystrophy each year in the US, Duchenne and Becker types, Genetics Home Reference website
730. Lymphangioleiomyomatosis 0.00% 1 in 544,000 500 Several hundred people in the USA (NHLBI)
731. Nocardiosis 0.00% 1 in 544,000 500 estimated 500-1,000 annual cases in USA (DBMD)
732. Maternal death 0.00% 1 in 695,652 391 391 women in 1999 (NVSR Sep 2001)
733. Mumps 0.00% 1 in 702,842 387 387 annual cases notified in USA 1999 (MMWR 1999); rare due to MMR vaccination
734. Rubella 0.00% 1 in 747,252 364 364 cases annually (1998); incidence greatly reduced by MMR vaccination programs
735. Typhoid fever 0.00% 1 in 786,127 346 346 annual cases notified in USA 1999 (MMWR 1999)
736. Carbamoyl-phosphate synthase 1 deficiency 0.00% 1 in 800,000 340 estimated 1 per 800,000 newborns suffer from carbamoyl phosphate synthetase I deficiency in Japan, Genetics Home Reference website
737. Ehrlichiosis 0.00% 1 in 900,662 301 302 annual cases (203 of human granulocytic ehrlichiosis and 99 of human monocytic ehrlichiosis) notified in USA 1999 (MMWR 1999)
738. Vibrio vulnificus 0.00% 1 in 906,666 300 less than 300 cases in 1988-1995 (DBMD)
739. Primary pulmonary hypertension 0.00% 1 in 906,666 300 300 new cases annually (NHLBI)
740. Prion disease 0.00% 1 in 906,666 300 approximately 300 cases of prion disease are diagnosed in the US each year, Genetics Home Reference website
741. Granuloma inguinale 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of donovanosis was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
742. Arbovirus 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of arbovirus infection was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
743. Hepatitis E 0.00% 1 in 1 million 272 0.1 new cases per 100,000 population of Hepatitis E was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)
744. Creutzfeldt-Jakob Disease 0.00% 1 in 1 million 271 1-per-million
745. Familial hyperchylomicronemia 0.00% 1 in 1 million 271 1 per 1 million suffer from familial lipoprotein lipase deficiency worldwide, Genetics Home Reference website
746. Crouzonodermoskeletal syndrome 0.00% 1 in 1 million 271 1 per 1 million people are affected by Crouzonodermoskeletal syndrome, Genetics Home Reference website
747. Pantothenate kinase-associated neurodegeneration 0.00% 1 in 1 million 271 estimated 1-3 per 1 million people are affected by Hallervorden-Spatz disease worldwide, Genetics Home Reference website
748. Homozygous Familial Hypercholesterolemia 0.00% 1 in 1 million 271 1 per 1 million US people suffer from Homozygous familial hypercholesterolemia.
749. Hemophilus influenzae B 0.00% 1 in 1 million 260 261 annual cases of invasive HIB in USA 1999 (MMWR 1999)
750. Vibrio 0.00% 1 in 1.2 million 233 7 cases in NJ 1998 (NJ DHSS)
751. Babesiosis 0.00% 1 in 1.2 million 233 7 cases in NJ 1998 (NJ DHSS)
752. Hemolytic uremic syndrome 0.00% 1 in 1.3 million 201 202 cases of postdiarrheal HUS in 28 USA states 2001 (Morbidity and Mortality Weekly Report, 2003)
753. Mucopolysaccharidosis type I Hurler-Scheie syndrome 0.00% 1 in 1.4 million 200 about 200 people ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
754. Botulism food poisoning 0.00% 1 in 1.8 million 153 154 annual cases notified in USA 1999 including 23 foodborne, 92 infant, and 39 other (MMWR 1999)
755. Chancroid 0.00% 1 in 1.9 million 143 143 annual cases notified in USA 1999 (MMWR 1999); rare in the USA but with occasional outbreaks.
756. Myositis ossificans 0.00% 1 in 2 million 135 estimated 1 per 2 million people are affected by fibrodysplasia ossificans progressiva, Genetics Home Reference website
757. Toxic Shock Syndrome 0.00% 1 in 2.4 million 112 113 annual cases notified in USA 1999 (MMWR 1999); 1-2 per 100,000 (DBMD)
758. Leprosy 0.00% 1 in 2.5 million 108 108 annual cases notified in USA 1999 (MMWR 1999)
759. Glucagonoma 0.00% 1 in 2.7 million 100 only 100 cases since 1974 (Ganda, 1997)
760. Leptospirosis 0.00% 1 in 2.7 million 100 100-200 cases annually in USA (DBMD)
761. Measles 0.00% 1 in 2.7 million 100 100 cases annually (1998); once common, now greatly reduced by MMR vaccination programs; 100 annual cases notified in USA 1999 (MMWR 1999)
762. Dengue fever 0.00% 1 in 2.7 million 100 about 100 to 200 cases annually in USA (NIAID)
763. POEMS 0.00% 1 in 2.7 million 100 about 100 known cases (Ganda [1997])
764. Infant botulism food poisoning 0.00% 1 in 2 million 92 92 annual cases notified in USA 1999 (MMWR 1999)
765. Brucellosis 0.00% 1 in 3.3 million 82 82 annual cases notified in USA 1999 (MMWR 1999)
766. Pregnancy-associated osteoporosis 0.00% 1 in 3.4 million 80 80 annual cases (NWHIC)
767. Encephalitis, California serogroup viral 0.00% 1 in 3.9 million 70 70 annual cases notified in USA 1999 (MMWR 1999)
768. Chronic Granulomatous Disease 0.00% 1 in 4 million 67 1-in-4 million to 5 million (NIAID)
769. Streptococcal Toxic Shock Syndrome 0.00% 1 in 4.5 million 61 61 annual cases notified in USA 1999 (MMWR 1999)
770. Cyclosporiasis 0.00% 1 in 4.9 million 55 56 annual cases notified in USA 1999 (MMWR 1999)
771. Beta ketothiolase deficiency 0.00% 1 in 5.4 million 49 50 - 60 cases of beta-ketothiolase deficiency have been reported worldwide, Genetics Home Reference website
772. Rheumatic conditions 0.00% 1 in 6.3 million 43 nearly 43 Americans have arthritis or a rheumatic disease (CDC); 40 million people in the United States (NIAMS)
773. Tetanus 0.00% 1 in 6.8 million 40 40 annual cases notified in USA 1999 (MMWR 1999); rare due to vaccination.
774. Hantavirus 0.00% 1 in 8.2 million 32 33 annual cases of Hantavirus pulmonary syndrome notified in USA 1999 (MMWR 1999)
775. Marine toxins 0.00% 1 in 9.1 million 29 approximately 30 cases annually in USA (DBMD)
776. Baylisascaris 0.00% 1 in 9.1 million 29 fewer than 30 cases have been reported (DPD)
777. Carnitine-acylcarnitine translocase deficiency 0.00% 1 in 9.1 million 29 about 30 cases of carnitine-acylcarnitine translocase deficiency have been confirmed, Genetics Home Reference website
778. Short QT syndrome 0.00% 1 in 9.1 million 29 less than 30 cases of short QT syndrome have been reported, Genetics Home Reference website
779. X-linked sideroblastic anemia 0.00% 1 in 12 million 22 several hundred cases of X-linked sideroblastic anemia have been reported worldwide, Genetics Home Reference website
780. East African Trypanosomiasis 0.00% 1 in 12 million 21 21 cases in USA (DPD)
781. Somatostatinoma 0.00% 1 in 13.6 million 20 20 known cases in the literature (Ganda, 1997)
782. Malonic aciduria 0.00% 1 in 13.6 million 20 less than 20 cases of malonic aciduria have been reported, Genetics Home Reference website
783. 3-methylglutaconic aciduria, type 1 0.00% 1 in 13.6 million 20 less than 20 cases of 2-methylglutaconic aciduria type 1 have been reported, Genetics Home Reference website
784. Alstrom disease 0.00% 1 in 14.1 million 19 about 425 cases of Alstrom disease reported worldwide, Genetics Home Reference website
785. Cadasil 0.00% 1 in 15 million 18 about 400 people have been diagnosed with CADASIL worldwide, Genetics Home Reference website
786. Psittacosis 0.00% 1 in 17 million 16 16 annual cases notified in USA 1999 (MMWR 1999)
787. Trichinosis 0.00% 1 in 22.7 million 11 12 annual cases notified in USA 1999 (MMWR 1999)
788. Plague 0.00% 1 in 30.2 million 9 9 annual cases of plague notified in USA 1999 (MMWR 1999)
789. Rubella congenital syndrome 0.00% 1 in 30.2 million 9 9 annual cases notified in USA 1999 (MMWR 1999)
790. Cholera 0.00% 1 in 45.3 million 5 6 annual cases notified in USA 1999 (MMWR 1999)
791. Gastrointestinal Basidiobolomycosis 0.00% 1 in 45.3 million 5 6 cases ever in history (CDC-OC)
792. Eastern equine encephalitis 0.00% 1 in 54.4 million 5 5 annual cases notified in USA 1999 (MMWR 1999)
793. Isobutyryl-coenzyme A dehydrogenase deficiency 0.00% 1 in 54.4 million 5 less than 5 cases of isobutyryl-coenzyme A dehydrogenase deficiency have been reported, Genetics Home Reference website
794. HMG-CoA lyase deficiency 0.00% 1 in 60 million 4 less than 100 people have been diagnosed with HMG-CoA lyase deficiency worldwide, Genetics Home Reference website
795. Andersen-Tawil syndrome 0.00% 1 in 60 million 4 100 people have been reported with Andersen-Tawil syndrome worldwide, Genetics Home Reference
796. St. Louis encephalitis 0.00% 1 in 68 million 4 4 annual cases notified in USA 1999 (MMWR 1999)
797. Respiratory diphtheria 0.00% 1 in 100 million 2 Approximately 0.001 per 100,000 in USA (DBMD)
798. Cutaneous diphtheria 0.00% 1 in 100 million 2 Approximately 0.001 cases per 100,000 population in the U.S. since 1980 (DBMD)
799. Tangier disease 0.00% 1 in 120 million 2 about 50 cases of Tangier disease have been diagnosed worldwide, Genetics Home Reference website
800. Carnitine palmitoyl transferase 1 deficiency 0.00% 1 in 120 million 2 less than 50 people suffer from Jervell and Lange-Nielsen syndrome worldwide, Genetics Home Reference website
801. Ethylmalonic aciduria 0.00% 1 in 200 million 1 about 30 cases of ethylmalonic encephalopathy have been reported worldwide, Genetics Home Reference website
802. Hydatidiform mole 0.00% 1 in 272 million 1 about 1 in 2000 pregnancies
803. Diphtheria 0.00% 1 in 272 million 1 1 annual case notified in USA 1999 (MMWR 1999)
804. Yellow fever 0.00% 1 in 272 million 1 1 annual case notified in USA 1999 (MMWR 1999)
805. Pseudotumor Cerebri 0.00% 1 in 272 million 1 about 1-2 people per 100,000 population have benign intracranial hypertension in the US (Association for Spina Bifida and Hydrocephalus)
806. Japanese encephalitis 0.00% 1 in 272 million 1 1 case annually in USA (DVBID)
807. Western equine encephalitis 0.00% 1 in 272 million 1 1 annual cases notified in USA 1999 (MMWR 1999)
808. Melioidosis 0.00% 1 in never 0 0-5 cases annually (DBMD)
809. Anthrax 0.00% 1 in never 0 0 annual cases notified in USA 1999 (MMWR 1999)
810. Polio 0.00% 1 in never 0 0 annual cases of paralytic poliomyelitis notified in USA 1999 (MMWR 1999)
811. Smallpox 0.00% 1 in never 0 0 cases throughout the world.
812. Lymphatic Filariasis 0.00% 1 in never 0 about 0 cases in the USA (DPD)
813. Kuru 0.00% 1 in never 0 0%; the disease is almost extinct.
814. Glanders 0.00% 1 in never 0 0 cases (CDC)
815. Viral Hemorrhagic Fevers 0.00% 1 in never 0 0 new cases of viral haemorrhagic fever per 100,000 population was notified in Australia 2002 (Yohannes K, Roche P, Blumer C et al. 2004, Australia’s Health 2004, AIHW)


Footnotes:
1. Traveller's Diarrhea, CDC/DBMD, Nov 21, 2006
2. Rose and Mackay, 1998, The Autoimmune Diseases, Third Edition
3. Childhood Symptoms, Edward R. Brace, John P. Pacanowski, Ed Weiner, 1992
4. Notifiable Diseases Online, PPHB, Canada, 2000
5. Pathophysiology of Disease, Stephen J. McPhee, Vishwanash R. Lingappa, Willim F. Ganong, Jack D. Lang, Prentice Hall, 1995
6. The Autoimmune Diseases, Noel R. Rose, Ian R. Mackay, 1998
 

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