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Conditions by Prevalence

Conditions here are listed according to prevalence, which is the estimated number of people who have the condition at a given time. This measure may differ from the incidence of the condition, which refers to new annual cases, and the rates below do not include incidence data in computations. For comparison, see conditions by people affected (prevalence or incidence), and conditions by incidence. See also details about prevalence and incidence statistics for more information. In most cases, rates refer to the USA or other industrialized nations.

Condition Percent Rate US People Data
1. Respiratory conditions 78.90% 1 in 1 214.6 million 78.9 per 100 (NHIS96)
2. Nonsyndromic deafness 70.00% 1 in 1 190.4 million 70-80% of cases of congenital hearing loss are not associated with any syndrome in the US, Genetics Home Reference website
3. Cytomegalovirus 50.00% 1 in 2 136 million 50% approximately; almost half of young adults (NIAID)
4. Cold sores 50.00% 1 in 2 136 million estimated 50 to 80% of Americans have HSV-1
5. Refractive Eye Disorders 44.12% 1 in 2 120 million 120 million people
6. High Cholesterol 37.13% 1 in 3 101 million estimated 101 million Americans have cholesterol >= 200 mg/dL (CDC)
7. Overweight 35.70% 1 in 3 97.1 million 97.1 million American adults
8. Chronic Illness 33.09% 1 in 3 90 million 90 million people in USA (CDC)
9. Tetrahydrobiopterin Deficiency 30.00% 1 in 3 81.6 million 30% of infants born with high phenylalanine levels have tetrahydrobiopterin deficiency in China, Genetics Home Reference website
10. Familial atrial fibrillation 30.00% 1 in 3 81.6 million estimated 30% of cases of atrial fibrillation are inherited (familial), Genetics Home Reference website
11. Myopia 25.74% 1 in 3 70 million 70 million Americans; over 25 percent of all adult Americans.
12. Insulin Resistance 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
13. Metabolic Syndrome 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
14. Genital herpes 24.63% 1 in 4 67 million 67 million people (NIAID)
15. Sexually Transmitted Diseases 23.90% 1 in 4 65 million 65 million people living with an incurable STD (CDC)
16. Cardiovascular Disease 22.72% 1 in 4 61.8 million 61,800,000 cases in the USA (American Heart Association, 2004)
17. Hyperopia 22.40% 1 in 4 60.9 million 22.4% of population self-reported having long-sightedness in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
18. Smoking 22.30% 1 in 4 60.7 million 22.3% of Americans smoke (CDC); 23 million American women smoke (NHLBI)
19. Toxoplasmosis 22.06% 1 in 4 60 million More than 60 million in USA but few have symptoms (DPD)
20. Digestive Diseases 22.06% 1 in 4 60 million 60 to 70 million cases in the USA 1985 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447)
21. Epstein-Barr virus 20.00% 1 in 5 54.4 million as many as 20% of people carry the virus in their throats
22. Hypertension 18.38% 1 in 5 50 million 50 million Americans (NHLBI); 217 per 1000 (NHIS95)
23. Dandruff 18.38% 1 in 5 50 million 50 million
24. Allergies 18.38% 1 in 5 50 million 50-60 million (NIAID); 9-16% (NIAID); 50 million cases annually (NIAID); 10% of American women (NHWIC); 8,526,000 children respiratory allergies (NHIS-97); 7,304,000 children non-respiratory allergies (NHIS-97)
25. Headache 16.54% 1 in 6 45 million 45 million Americans get chronic headaches. 20 million American women (NWHIC).
26. Chronic headache 16.54% 1 in 6 45 million estimated 45 million Americans (NINDS)
27. Astigmatism 16.54% 1 in 6 45 million 45 million Americans (dubious estimate based on "two thirds of people with myopia also have astigmatism")
28. Impaired glucose tolerance 15.07% 1 in 6 41 million estimated 41 million people aged 40-74 have pre-diabetes in the US 1988-94 (National Diabetes Statistics fact sheet, NIDDK, 2003)
29. Premenstrual syndrome 15.00% 1 in 6 40.8 million 30-40% women suffer some impairment of daily activity (NWHIC); 75% women have some symptoms; 3-8% women have severe PMS (NWHIC).
30. Orthopedic disorders 14.90% 1 in 6 40.5 million 149 per 1000 - NHIS95
31. Sleep disorders 14.71% 1 in 6 40 million approximately 40 million Americans (NHLBI)
32. Obesity 14.63% 1 in 6 39.8 million 39.8 million American adults; more than 57% of American adults are overweight (CDC)
33. Arthritis 13.60% 1 in 7 37 million 37 million Americans (NIAMS)
34. Sinusitis 13.60% 1 in 7 37 million 37 million annually in the USA; 33 million reported to CDC (NIAID)
35. Hay fever 12.87% 1 in 7 35 million 35 million Americans (NIAID: pollen allergies)
36. Pollen allergy 12.87% 1 in 7 35 million estimated 35 million Americans with pollen allergies (NIAID)
37. Androgenetic alopecia 12.87% 1 in 7 35 million estimated 35 million men suffer from androgenetic alopecia in the US, Genetics Home Reference website
38. Chronic Sinusitis 12.60% 1 in 7 34.3 million 12.6% (NIAID); 152 per 1000 - NHIS95
39. Insomnia 11.76% 1 in 8 32 million 32 million (unreliable estimate)
40. Chronic lower respiratory diseases 11.76% 1 in 8 32 million estimated 32 million including 15 million undiagnosed
41. Lung conditions 11.03% 1 in 9 30 million more than 30 million Americans with chronic lung diseases (NWHIC)
42. Impotence 11.03% 1 in 9 30 million 30 million men (NIDDK)
43. Lactose Intolerance 11.03% 1 in 9 30 million 30 million people to 50 million people (NIDDK 1994); about 25% of population (1994/NIDDK)
44. Osteoporosis 10.29% 1 in 9 28 million 28 million Americans (10 million with osteoporosis; 18 million with low bone mass); eight million American women and 2 million men (NWHIC)
45. Migraine 10.29% 1 in 9 28 million 28 million Americans (NINDS)
46. Mole 10.00% 1 in 10 27.2 million common; most people have 10-40 moles.
47. Molluscum contagiosum 10.00% 1 in 10 27.2 million Common.
48. Scabies 10.00% 1 in 10 27.2 million common
49. Retroverted uterus 10.00% 1 in 10 27.2 million about 1 in 5 women
50. Allergic rhinitis 10.00% 1 in 10 27.2 million 10% of the population with allergic rhinitis/hay fever in the US (Mayo Clinic)
51. Otosclerosis 10.00% 1 in 10 27.2 million as many as 10% of Caucasians have the condition but most do not get symptoms; about 1 in 100 cases actually lose hearing from otosclerosis
52. Extra Nipples 10.00% 1 in 10 27.2 million about 1 in 10 people but most are small and mistaken for freckles or moles
53. Glucose-6-Phosphate Dehydrogenase Deficiency 10.00% 1 in 10 27.2 million 1 in 10 African-American males suffer from glucose-6-phosphate dehydrogenase deficiency in the US, Genetics Home Reference website
54. Amyotrophic lateral sclerosis, familial 10.00% 1 in 10 27.2 million 10% of all cases of amyotrophic lateral sclerosis are familial, Genetics Home Reference website
55. Depressive disorders 9.50% 1 in 10 25.8 million 9.5 percent of adult Americans (NIMH)
56. Rare diseases 9.19% 1 in 10 25 million about 25 million Americans (ORD); each disease less than 200,000 Americans by definition.
57. Presbyopia 9.00% 1 in 11 24.5 million 9.0% of population self-reported having presbyopia in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
58. Back Impairment 8.50% 1 in 11 23.1 million 85 per 1000 - NHIS95 (deformity or orthopedic impairment of back)
59. Heart disease 8.09% 1 in 12 22 million 22 million adults in the US 2000 (Centers for Disease Control and Prevention)
60. Hearing Impairment 8.09% 1 in 12 22 million 22 million; 158 per 1000 (NHIS95)
61. Thyroid disorders 7.35% 1 in 13 20 million 20 million Americans (NWHIC)
62. Human Papillomavirus 7.35% 1 in 13 20 million 20 million Americans currently infected (NIAID; CDC 2001)
63. Osteoarthritis 7.35% 1 in 13 20 million 20 million people (NIAMS); more than 16 million people (NWHIC)
64. Mood disorders 7.10% 1 in 14 19.3 million estimated 7.1% adults (USSG)
65. Ischemic heart disease 6.80% 1 in 14 18.5 million 68 per 1000 (NHIS95)
66. Sleep apnea 6.62% 1 in 15 18 million estimated 18 million Americans (NHLBI)
67. Asthma 6.40% 1 in 15 17.4 million 6.4% USA (NIAID); 17 million Americans (NIAID) including 5 million children; 8.1 million children (NHIS-97), 51 per 1000 - NHIS95; 14.5 million; 5% of population (NWHIC); 14.9 million in 1995 (NHLBI)
68. Acne 6.25% 1 in 16 17 million 17 million Americans, almost 85% of people 12-24 years of age.
69. Diabetes 5.88% 1 in 17 16 million 16 million Americans with 10.3 million diagnosed and 8.1 million women (NWHIC); 65 per 1000 - NHIS95; 8 million - perhaps 16 million if include not-yet-diagnosed.
70. Type 2 diabetes 5.88% 1 in 17 16 million 16 million Americans (NWHIC, includes undiagnosed); 7.2 million (actually diagnosed)
71. Gallstones 5.88% 1 in 17 16 million 16 to 22 million people in the USA 1976-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, NIDDK, 1994)
72. Crouzon Syndrome 5.88% 1 in 17 16 million 16 million newborns suffer from Crouzon syndrome, Genetics Home Reference website
73. Alcoholism 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
74. Alcohol abuse 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
75. Eczema 5.51% 1 in 18 15 million 15 million people (NIAMS); 10% infants/children estimated (NIAMS); 9% (NIAID); 8.5 million
76. Gynecomastia 5.51% 1 in 18 15 million 15 million - 15% of adult men to some extent (unreliable estimate)
77. Heartburn 5.51% 1 in 18 15 million 15 million Americans have it daily (NIDDK)
78. Depression 5.30% 1 in 18 14.4 million estimated 5.3% adults (USSG); 17 million people; approximately 4% of adolescents get seriously depressed (NIMH); annually 12% of women ; 7% of men; lifetime risk of an episode for women 20%. 3-4 million men USA.
79. Arrhythmias 5.30% 1 in 18 14.4 million 53 per 1000 (NHIS95: heart rhythm disorders); 21 per 1000 (NHIS95: heart murmurs)
80. Urinary stones 5.20% 1 in 19 14.1 million 5.2% of adults in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
81. Raynaud's phenomenon 5.00% 1 in 20 13.6 million 5-10% (NIAMS estimate). Scleroderma-related disorders including Raynaud's phenomenon between 250,000 and 992,500.
82. Uterine fibroids 5.00% 1 in 20 13.6 million 10-20% women (NWHIC)
83. Endometriosis 5.00% 1 in 20 13.6 million 10 to 20 percent of American women of childbearing age have endometriosis (NIDCD); up to 2 million women in the UK.
84. Red-green color blindness 5.00% 1 in 20 13.6 million about 10% of males
85. Congenital myotonic dystrophy 5.00% 1 in 20 13.6 million 5 per 100 000 people suffer from myotonic dystrophy in the US
86. COPD 4.96% 1 in 20 13.5 million 13.5 million Americans (NHLBI)
87. Coronary heart disease 4.85% 1 in 20 13.2 million estimated 13,200,000 in the USA 2001 (American Heart Association, 2004)
88. Urinary Incontinence 4.78% 1 in 20 13 million 13 million adults (NIDDK); 1 in 10 over 65 (NWHIC).
89. Rosacea 4.78% 1 in 20 13 million 13 million people in the United States (NIAMS)
90. Varicose veins 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95)
91. Tinnitus 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95); 12 million Americans
92. Chronic Bronchitis 4.45% 1 in 22 12.1 million 12.1 million Americans (NHLBI)
93. Obstructive sleep apnea 4.41% 1 in 22 12 million 12 million Americans
94. Genetic Disease 4.41% 1 in 22 12 million 12 million Americans - unreliable estimate, (perhaps 2.5% births)
95. Phobias 4.23% 1 in 23 11.5 million 11.5 million adults (NIMH); 8.0% adults (NIMH)
96. Cornea disorders 4.04% 1 in 24 11 million 11,000,000 people experience corneal disorders such as herpes or dry eye in the US (Research to Prevent Blindness, NISE, NSF)
97. Dysthymia 4.01% 1 in 24 10.9 million about 10.9 million American adults (NIMH); estimated 1.6% adults (USSG)
98. Presbycusis 3.90% 1 in 25 10.6 million 30-35% over 65 have some hearing loss, 40-50% over 70.
99. Hemorrhoids 3.82% 1 in 26 10.4 million 10.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
100. Latent tuberculosis 3.68% 1 in 27 10 million estimated 10 to 15 million people in USA (NIAID)
101. Jaw conditions 3.68% 1 in 27 10 million estimated 10 million women in the USA (NWHIC)
102. Age-related macular degeneration 3.68% 1 in 27 10 million 10,000,000 people have reduced vision due to age-related macular degeneration in the US (Research to Prevent Blindness, NISE, NSF)
103. Indigestion 3.50% 1 in 28 9.5 million 35 per 1000 - NHIS95 (frequent indigestion)
104. Dermatitis 3.30% 1 in 30 8 million 33 per 1000 (NHIS95)
105. Insect sting allergies 3.30% 1 in 30 8 million 3.3% (NIAID); up to 5% of the population (NHWIC)
106. Bursitis 3.20% 1 in 31 8.7 million 32 per 1000 (NHIS95)
107. Autoimmune diseases 3.13% 1 in 31 8.5 million 8,511,845 people in the USA 1996 1
108. Dry skin 3.10% 1 in 32 8.4 million 31 per 1000 - NHIS95 (trouble with dry/itching skin)
109. Disc Disorders 3.10% 1 in 32 8.4 million 31 per 1000 (NHIS95: intervertebrate disc disorders)
110. Paget's disease of bone 3.00% 1 in 33 8.2 million about 3% of people aged over 40; 10% by age 80.
111. Retinoblastoma 3.00% 1 in 33 8.2 million 3% of cancers in children under the age of 15 are due to retinoblastomas, Genetics Home Reference website
112. Congenital conditions 3.00% 1 in 33 8.2 million 3-4% of babies (NWHIC)
113. Gastroesophageal Reflux Disease 3.00% 1 in 33 8.2 million 3-7% of the population in the USA 1985 for "GERD and related esophageal disorders" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
114. Urinary tract infections (child) 3.00% 1 in 33 8.2 million 3% of girls and 1% of boys before age 11
115. Cerebrovascular Conditions 3.00% 1 in 33 8.2 million 30 per 1000 - NHIS95
116. Amyotrophic lateral sclerosis type 1 3.00% 1 in 33 8.2 million 3% of sporadic cases of amyotrophic lateral sclerosis are type 1, Genetics Home Reference website
117. Heart attack 2.76% 1 in 36 7.5 million 7.5 million people with AMI (NHLBI)
118. Squint 2.76% 1 in 36 7.5 million 7,500,000 people suffer from strabismus or cross eyes in the US (Research to Prevent Blindness, NISE, NSF)
119. Kidney disease 2.72% 1 in 36 7.4 million 7.4 million adults in the USA 1988-94 (American Journal of Kidney Disease)
120. Prostate conditions 2.60% 1 in 38 7.1 million 52 per 1000 men - NHIS95; 2,803 million men (NIDDK)
121. Ingrown nails 2.60% 1 in 38 7.1 million 26 per 1000 - NHIS95 (trouble with ingrown nails)
122. Callus 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
123. Corns 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
124. Polycystic ovary syndrome 2.50% 1 in 40 6.8 million 5-10% women of childbearing age (20-40); 30% of women have some PCOS symptoms (NWHIC).
125. Fecal incontinence 2.39% 1 in 41 6.5 million 6.5 million Americans
126. Angina 2.35% 1 in 42 6.4 million 6.4 million Americans (NHLBI)
127. Specific phobias 2.32% 1 in 43 6.3 million estimated 6.3 million adult Americans (NIMH); estimated 8.3% adults (USSG)
128. Cystitis 2.28% 1 in 43 6.2 million 6.2 million adults self-reported having a bladder infection for more than 3 months in the US 1988-1994 (Weighted Analysis of 1988-1994, NHANES, NIDDK)
129. Back pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
130. Nonulcer dyspepsia 2.13% 1 in 46 5.8 million 5.8 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
131. Anti-Social Personality Disorder 2.10% 1 in 47 5.7 million estimated 2.1% adults (USSG)
132. Cataracts 2.02% 1 in 49 5.5 million 5,500,000 people have a cataract interfering with their vision in the US (Research to Prevent Blindness, NISE, NSF)
133. Psoriasis 2.02% 1 in 49 5.5 million 5.5 million people in the USA (NIAMS)
134. Autoimmune thyroid diseases 2.00% 1 in 50 5.4 million 4 out of 100 women some type of autoimmune thyroid disease
135. Borderline Personality Disorder 2.00% 1 in 50 5.4 million 2 percent of adults (NIMH)
136. Cyclic vomiting syndrome 2.00% 1 in 50 5.4 million 1 in 50 children (perhaps)
137. Penicillin allergy 2.00% 1 in 50 5.4 million 2-3% of people (2-3% of hospitalized patients)
138. Mitral-valve prolapse 2.00% 1 in 50 5.4 million 2% of the adult population (NHLBI estimate)
139. Hereditary nonpolyposis colon cancer 2.00% 1 in 50 5.4 million 2-7% of all colorectal cancers are due to hereditary nonpolyposis colorectal cancer
140. Social phobia 1.95% 1 in 51 5.3 million 5.3 million adult Americans (NIMH); 3.7% adults (NIMH); 2.0% adults (USSG)
141. Bunions 1.92% 1 in 51 5.2 million 19.25 per 1000 - NHIS95 (trouble with bunions)
142. Post-traumatic stress disorder 1.91% 1 in 52 5.2 million 5.2 million adult Americans (NIMH); 3.6% adults (NIMH); about 30% of war veterans.
143. Female genital disorders 1.90% 1 in 52 5.2 million 38 per 1000 women (NHIS95)
144. Irritable bowel syndrome 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, 1994); 11 per 1000 (NHIS95)
145. Peptic Ulcer 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
146. Eating disorders 1.84% 1 in 54 5 million 5 million women (NWHIC); 1-4% of young women
147. Heart failure 1.76% 1 in 56 4.8 million 4.8 million (NHLBI); 2 to 3 million Americans (NHLBI)
148. Congestive Heart Failure 1.76% 1 in 56 4.8 million 4.8 million Americans (NHLBI); 2% age 40-59; 5% age 60-69; 10% over 70's
149. Atherosclerosis 1.70% 1 in 58 4.6 million 17 per 1000 - NHIS95
150. Learning disabilities 1.69% 1 in 59 4.6 million 4.6 million children (NHIS-97)
151. Stroke 1.69% 1 in 59 4.6 million estimated 4.6 million (NHLBI)
152. Abdominal Hernia 1.65% 1 in 60 4.5 million 4.5 million people in the USA 1988-90 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
153. Constipation 1.62% 1 in 61 4.4 million 4.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
154. Edema 1.60% 1 in 62 4.4 million 1.6% of population self-reported having oedema in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
155. Tachycardia 1.60% 1 in 62 4.4 million 16 per 1000 (NHIS95)
156. Kidney conditions 1.50% 1 in 66 4.1 million 15 per 1000 (NHIS95: "kidney trouble")
157. Alzheimer's Disease 1.47% 1 in 68 4 million more than 4 million Americans (CDC); estimated 4 million people in the U.S (NHWIC)
158. Drug abuse 1.47% 1 in 68 4 million more than 4 million women need treatment for drug abuse (NWHIC)
159. Generalized anxiety disorder 1.47% 1 in 68 4 million 4 million adult Americans (NIMH); 2.8% adults (NIMH); estimated 3.4% adults (USSG)
160. Chronic Hepatitis C 1.47% 1 in 68 4 million Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK).
161. Deafness 1.47% 1 in 68 4 million 4 million people (unreliable estimate)
162. Thrombotic thrombocytopenic purpura, acquired 1.47% 1 in 68 4 million estimated 4-7 million people are diagnosed with thrombotic thrombocytopenic purpura each year in the US, Genetics Home Reference website
163. Fibromyalgia 1.36% 1 in 73 3.7 million 3.7 million Americans (NIAMS)
164. Color blindness 1.30% 1 in 76 3.5 million 13 per 1000 - NHIS95
165. Anemia 1.29% 1 in 77 3.5 million 3.5 million (NHLBI)
166. ADD 1.21% 1 in 82 3.3 million 3.3 million children have ADD in the USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
167. ADHD 1.21% 1 in 82 3.3 million 3.3 million children have ADD in the USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
168. Attention Deficit Hyperactivity Disorder 1.21% 1 in 82 3.3 million 3.3 million children have ADD in USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
169. Obsessive-compulsive disorder 1.21% 1 in 82 3.3 million 3.3 million adult Americans (NIMH); 2.3% adults (NIMH); 1 in 50 people (NWHIC); 2.4% adults (USSG)
170. Bipolar disorder 1.20% 1 in 83 3.3 million 1.2 percent of the population; 2.3 million adult Americans (NIMH)
171. Agoraphobia 1.18% 1 in 84 3.2 million approximately 3.2 million American adults ages 18 to 54 (NIMH); estimated 4.9% adults (USSG)
172. Graves Disease 1.12% 1 in 89 3 million 3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC)
173. Von Willebrand disease 1.10% 1 in 90 3 million estimated 3 million mostly undiagnosed
174. Open-angle glaucoma 1.10% 1 in 90 3 million about 3 million Americans, many not yet diagnosed.
175. Peanut allergies 1.10% 1 in 90 3 million 3 million Americans (peanut and tree nut combined; NIAID)
176. Dental conditions 1.10% 1 in 90 2 million 1.1 per 100 (NHIS96: acute dental conditions)
177. Stuttering 1.00% 1 in 100 2.7 million about 1% of adults
178. Deuteranopia 1.00% 1 in 100 2.7 million about 1% of white males
179. Protanopia 1.00% 1 in 100 2.7 million about 1% of white males
180. Food allergies 1.00% 1 in 100 2.7 million 1% of the adult population have a true immune reaction to food (NHWIC)
181. Latex allergies 1.00% 1 in 100 2.7 million 1-6% (NIAID)
182. Speech impairment 1.00% 1 in 100 2.7 million 10 per 1000 (NHIS95)
183. Glomus vagale tumors 1.00% 1 in 100 2.7 million 1% of glomus tumors are malignant
184. Gastritis 0.99% 1 in 100 2.7 million 2.7 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
185. Rheumatoid arthritis 0.92% 1 in 108 2.5 million 2.5 million Americans (NWHIC); 1% of US population (NIAMS)
186. Paralysis 0.90% 1 in 111 2.4 million 9 per 1000 - NHIS95 (paralysis of extremeties complete/partial)
187. Panic disorder 0.88% 1 in 113 2.4 million approximately 2.4 million Americans (NIMH)
188. Vision Impairment 0.88% 1 in 113 2.4 million 2.4 million Americans
189. Epilepsy 0.85% 1 in 118 2.3 million 2.3 million Americans (CDC)
190. Uveitis 0.85% 1 in 118 2.3 million 2,300,000 people suffer uveitis in the US (Research to Prevent Blindness, NISE, NSF)
191. Schizophrenia 0.81% 1 in 123 2.2 million Approximately 2.2 million American adults (NIMH); estimated 1.3% adults (USSG); more than 2 million Americans
192. Deviated Septum 0.80% 1 in 124 2.2 million 8 per 1000 - NHIS95
193. Glaucoma 0.74% 1 in 136 2 million 2,000,000 people are visually impaired by glaucoma in the US (Research to Prevent Blindness, NISE, NSF)
194. Vitiligo 0.74% 1 in 136 2 million 2 to 5 million people in the USA (1-2% worldwide); 1,059,560 people in the USA 1996 1
195. Diverticular Disease 0.74% 1 in 136 2 million 2 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
196. Hepatitis C 0.74% 1 in 136 2 million estimated 2 to 5 million HCV chronic carriers
197. Alcoholic liver disease 0.74% 1 in 136 2 million More than 2 million Americans (NIAAA)
198. Emphysema 0.74% 1 in 136 2 million 2 million Americans (NHLBI); 17 per 1000 - NHIS95; 2 million annually
199. Atrial Fibrillation 0.74% 1 in 136 2 million 2 million (NHLBI)
200. Polymyalgia rheumatica 0.70% 1 in 142 1.9 million 700 per 100,000 people over 50.
201. Chronic tonsilitis 0.70% 1 in 142 1.9 million 7 per 1000 - NHIS95 (chronic disease of tonsils or adenoids)
202. Amputation 0.70% 1 in 142 1.9 million 7 per 1000 (NHIS95: excludes toes/fingers only)
203. Binge eating disorder 0.70% 1 in 142 1.9 million 0.7% to 4% of the general population (NWHIC); 2-5% of adults (NIMH); 2% of adults (NIDDK); 2% adults or 1-2 million adults (NWHIC)
204. Retina Conditions 0.66% 1 in 151 1.8 million 1,800,000 people have severely impaired vision because of retinal disease in the US (Research to Prevent Blindness, NISE, NSF)
205. Hepatitis B 0.55% 1 in 181 1.5 million estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001)
206. Bulimia nervosa 0.55% 1 in 181 1.5 million estimated 1.1 to 4.2 percent of females (NIMH); 2-3% of young women (NWHIC)
207. Hashimoto's Thyroiditis 0.55% 1 in 182 1.5 million 1,490,371 adults and 205,159 children in the USA 1996 1
208. Lupus 0.51% 1 in 194 1.4 million 1.4 million people in the United States, 1 in 85 (NWHIC)
209. Wegener's granulomatosis 0.50% 1 in 200 1.4 million uncommon
210. HTLV 0.50% 1 in 200 1.4 million uncommon
211. HTLV-1 0.50% 1 in 200 1.4 million uncommon
212. Peyronie's disease 0.50% 1 in 200 1.4 million 1 per 100 men
213. Sebaceous cyst 0.50% 1 in 200 1.4 million 5 per 1000 - NHIS95
214. Cerebral cavernous malformations 0.50% 1 in 200 1.4 million 0.5% of people suffer from cerebral cavernous malformations worldwide, Genetics Home Reference website
215. Bladder Incontinence (Pregnancy) 0.49% 1 in 203 1.3 million 1-in-3 pregnant women approximately
216. Blindness 0.40% 1 in 247 1.1 million 1,100,000 people are legally blind in the US (Research to Prevent Blindness, NISE, NSF)
217. Celiac Disease 0.40% 1 in 249 1.1 million 1 in 250 Americans estimated rate; actual diagnosis rate is 1 in 4,700 Americans; 1 in 250 in Italy; 1 in 300 in Ireland; 20,000 diagnosed (Reader's Digest Feb 2004)
218. 2-methylbutyryl-coenzyme A dehydrogenase deficiency 0.40% 1 in 249 1.1 million 1 per 250 - 500 people from Hmong populations in southeast Asia and America suffer from 2-methylbutyryl-coenzyme A dehydrogenase deficiency though many are asymptomatic, Genetics Home Reference website
219. Familial Mediterranean fever 0.40% 1 in 249 1.1 million estimated 1 per 250 - 1,000 people of Armenian, Arabic, Turkish, Jewish and Mediterranean ancestry suffer from Familial Mediterranean Fever, Genetics Home Reverence website
220. Sjogren's Syndrome 0.37% 1 in 272 1 million 1 to 4 million people with Sjogren’s Syndrome (NIAMS)
221. Connective tissue disorders 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
222. Congenital heart defects 0.37% 1 in 272 1 million 1 million (NHLBI)
223. Aphasia 0.37% 1 in 272 1 million 1 million Americans (NINDS)
224. Hemochromatosis 0.37% 1 in 272 1 million more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK); 1-in-200 to 1-in-300
225. Parkinson's Disease 0.37% 1 in 272 1 million 1 million people (unreliable estimate)
226. Heritable Disorders of Connective Tissue 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
227. Hemochromatosis type 1 0.37% 1 in 272 1 million 1 million people suffer from hemochromatosis type 1 in the US, Genetics Home Reference website
228. Selective IgA Deficiency 0.33% 1 in 300 906,666 1 in 300 (NIDCD); 1 in 600 (NIAID); 1 in 333 Caucasians.
229. Multiple endocrine neoplasia type 2 0.33% 1 in 300 906,666 about 1 per 300 000 people suffer from multiple endocrine neoplasia type 1 in the US, Genetics Home Reference website
230. Glutaricaciduria I 0.33% 1 in 300 906,666 estimated 1 per 300 people from the Ojibwa population of Canada suffer from glutaric academia type I, Genetics Home Reference website
231. HIV/AIDS 0.33% 1 in 302 900,000 900,000 Americans (NIAID, quarter are unaware)
232. Interstitial cystitis 0.31% 1 in 321 847,000 847,000 in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
233. Neuralgia 0.30% 1 in 333 816,000 3 per 1000 - NHIS95 (neuralgia or neuritis unspecified)
234. Scoliosis 0.30% 1 in 333 816,000 3-per-1,000 to 5-per-1000 children (NIAMS)
235. Variegate porphyria 0.30% 1 in 333 816,000 approximately 3 per 1,000 white South Africans suffer from variegate porphyria, Genetics Home Reference website
236. Chronic Hepatitis B 0.28% 1 in 362 750,000 750,000 people in the United States (NIAID)
237. Gout 0.28% 1 in 363 748,000 275 per 100,000 people (NIAMS)
238. Maple syrup urine disease 0.26% 1 in 384 706,493 estimated 1 per 385 infants suffer from maple syrup urine disease in the Old Order Mennonite population, Genetics Home Reference website
239. Red-green color vision defects 0.25% 1 in 400 680,000 estimated 0.5% of females of Northern European ancestry suffer from red-green color vision defects, Genetics Home Reference website
240. Bacterial vaginosis 0.24% 1 in 424 640,000 16% of pregnant women (DSTD)
241. Polycystic kidney disease 0.22% 1 in 453 600,000 600,000 Americans
242. Inflammatory bowel disease 0.20% 1 in 500 544,000 1 in 500 (NIAID); 300,000 people to 500,000 people NIDDK
243. Klinefelter syndrome 0.20% 1 in 500 544,000 1 per 500 - 1,000 males are affected by Klinefelter syndrome, Genetics Home Reference website
244. Autism 0.20% 1 in 500 544,000 1 in 500 to 1 in 2,500 (NIMH); 1-in-1000 to 2-in-1000, depending on diagnostic criteria
245. Nonaffective Psychosis 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
246. Somatization Disorder 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
247. Traumatic Brain Injury 0.20% 1 in 500 544,000 0.2% of population has an acquired brain injury in Australia 1998 (Australia’s Health 2004, AIHW)
248. Temporal arteritis 0.20% 1 in 500 544,000 200 per 100,000 people over 50.
249. Hypertrophic cardiomyopathy 0.20% 1 in 500 544,000 0.2 percent of the U.S. population
250. Gaucher disease type 1 0.20% 1 in 500 544,000 1 per 500 - 1,000 people of Ashkenazi Jewish heritage are affected by type 1 Gaucher disease, Genetics Home Reference website
251. Heterozygous Familial Hypercholesterolemia 0.20% 1 in 500 544,000 1 per 500 US people suffer from Heterozygous familial hypercholesterolemia.
252. Autosomal dominant polycystic kidney disease 0.20% 1 in 503 540,000 540,000 Americans approximately (90% of PKD)
253. Crohn's disease 0.18% 1 in 544 500,000 500,000 Americans
254. Chronic Fatigue Syndrome 0.18% 1 in 544 500,000 500,000 Americans (CDC/NIAID)
255. Liver conditions 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
256. Chronic liver disease 0.15% 1 in 679 400,000 400,000 people
257. Cirrhosis of the liver 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
258. Ocular Herpes 0.15% 1 in 679 400,000 400,000 Americans have had some form
259. Pernicious anemia 0.15% 1 in 680 399,454 399,455 people in the USA 1996 1
260. End-stage renal disease 0.14% 1 in 693 392,022 392,023 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
261. Multiple Sclerosis 0.14% 1 in 700 388,571 1-in-700 (NIAID)
262. Ankylosing Spondylitis 0.13% 1 in 775 350,879 129 of every 100,000 people in the US (Mayo Clinic)
263. Type 1 diabetes 0.12% 1 in 800 340,000 1-in-800 (NIAID)
264. Scleroderma 0.11% 1 in 906 300,000 estimated 300,000 Americans (NWHIC)
265. Kidney Dialysis 0.11% 1 in 946 287,493 287,494 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
266. Triple-X syndrome 0.10% 1 in 1,000 272,000 1 per 1,000 newborn girls suffer from triple X syndrome, Genetics Home Reference website
267. Sickle Cell Anemia 0.10% 1 in 1,000 272,000 estimated 1 per 1,000 Hispanic Americans are affected by sickle cell disease in the US, Genetics Home Reference website
268. Tourette Syndrome 0.10% 1 in 1,000 272,000 estimated 1-10 per 1,000 children have Tourette syndrome, Genetics Home Reference website
269. Anorexia Nervosa 0.10% 1 in 1,000 272,000 estimated 0.1% adults (USSG); estimated 0.5 to 3.7 percent females (NIMH); 1% of adolescent girls (NWHIC)
270. Wolf-Parkinson-White syndrome 0.10% 1 in 1,000 272,000 1-3 per 1,000 people suffer from Wolff-Parkinson-White syndrome worldwide, Genetics Home Reference website
271. Noonan Syndrome 0.10% 1 in 1,000 272,000 estimated 1 per 1,000 - 2,500 people are affected by Noonan syndrome, Genetics Home Reference website
272. Von Hippel-Lindau Disease 0.07% 1 in 1,359 200,000 rare
273. Zollinger-Ellison syndrome 0.07% 1 in 1,359 200,000 rare
274. Lichen sclerosis 0.07% 1 in 1,359 200,000 rare
275. Immune Thrombocytopenic Purpura 0.07% 1 in 1,359 200,000 rare.
276. Behcet's Disease 0.07% 1 in 1,359 200,000 rare in the USA; more common in Middle East, Asia, and Japan.
277. Penile candidiasis 0.07% 1 in 1,359 200,000 rare
278. Ascariasis 0.07% 1 in 1,359 200,000 rare
279. Zellweger Syndrome 0.07% 1 in 1,359 200,000 rare
280. Congenital SMA with arthrogryposis 0.07% 1 in 1,359 200,000 rare
281. Agenesis of the corpus callosum 0.07% 1 in 1,359 200,000 rare
282. Aicardi syndrome 0.07% 1 in 1,359 200,000 rare
283. Empty Sella Syndrome 0.07% 1 in 1,359 200,000 rare
284. Hydranencephaly 0.07% 1 in 1,359 200,000 rare
285. Klippel Feil Syndrome 0.07% 1 in 1,359 200,000 rare
286. Mobius syndrome 0.07% 1 in 1,359 200,000 rare
287. Chediak-Higashi Syndrome 0.07% 1 in 1,359 200,000 rare
288. Machado-Joseph Disease 0.07% 1 in 1,359 200,000 rare
289. Kearns-Sayre Syndrome 0.07% 1 in 1,359 200,000 rare
290. Alpers Syndrome 0.07% 1 in 1,359 200,000 rare
291. Agnosia 0.07% 1 in 1,359 200,000 rare
292. Alexander Syndrome 0.07% 1 in 1,359 200,000 rare
293. Alternating Hemiplegia 0.07% 1 in 1,359 200,000 rare
294. Binswanger's Disease 0.07% 1 in 1,359 200,000 rare
295. Brown-Sequard Syndrome 0.07% 1 in 1,359 200,000 rare
296. Fabry's Disease 0.07% 1 in 1,359 200,000 rare
297. Fahr's Syndrome 0.07% 1 in 1,359 200,000 rare
298. Hallervorden-Spatz disease 0.07% 1 in 1,359 200,000 rare
299. Joubert Syndrome 0.07% 1 in 1,359 200,000 rare
300. Krabbé Disease 0.07% 1 in 1,359 200,000 rare
301. Landau-Kleffner Syndrome 0.07% 1 in 1,359 200,000 rare
302. Microcephaly 0.07% 1 in 1,359 200,000 rare
303. Miller Fisher Syndrome 0.07% 1 in 1,359 200,000 rare
304. Moyamoya Disease 0.07% 1 in 1,359 200,000 rare
305. Parry Romberg Syndrome 0.07% 1 in 1,359 200,000 rare
306. Pelizaeus-Merzbacher Disease 0.07% 1 in 1,359 200,000 rare
307. Primary Lateral Sclerosis 0.07% 1 in 1,359 200,000 rare
308. Progressive Supranuclear Palsy 0.07% 1 in 1,359 200,000 rare
309. Rasmussen's Encephalitis 0.07% 1 in 1,359 200,000 rare
310. Sandhoff Disease 0.07% 1 in 1,359 200,000 rare
311. Schilder's Disease 0.07% 1 in 1,359 200,000 rare
312. Septo-Optic Dysplasia 0.07% 1 in 1,359 200,000 rare
313. Soto's Syndrome 0.07% 1 in 1,359 200,000 rare
314. Stiff-Person Syndrome 0.07% 1 in 1,359 200,000 rare
315. Subacute Sclerosing Panencephalitis 0.07% 1 in 1,359 200,000 rare - because of the rarity of measles due to vaccination programs.
316. Ménétrier's disease 0.07% 1 in 1,359 200,000 rare
317. Goodpasture syndrome 0.07% 1 in 1,359 200,000 rare.
318. Encephaloceles 0.07% 1 in 1,359 200,000 rare
319. Narcolepsy 0.07% 1 in 1,359 200,000 200,000 Americans (NHLBI estimate); 50,000 diagnosed.
320. Mastocytosis 0.07% 1 in 1,359 200,000 rare
321. Cutaneous mastocytosis 0.07% 1 in 1,359 200,000 rare
322. Restrictive cardiomyopathy 0.07% 1 in 1,359 200,000 rare
323. Charcot-Marie-Tooth Disorder 0.06% 1 in 1,813 150,000 150,000 people are affected by Charcot-Marie-Tooth disease in the US, Genetics Home Reference website
324. Hepatorenal tyrosinemia 0.05% 1 in 1,845 147,345 1 per 1,846 people from the Saguenay-La St. Jean region of Quebec suffer from tyrosinemia type 1, Genetics Home Reference website
325. Ménière's disease 0.05% 1 in 1,973 137,847 about 10,000 people in Australia
326. Jacobs syndrome 0.05% 1 in 2,000 136,000 1-in-2000 approximately.
327. Keratoconus 0.05% 1 in 2,000 136,000 1-in-2000 Americans
328. Brugada Syndrome 0.05% 1 in 2,000 136,000 estimated 5 per 10,000 people suffer from Brugada syndrome worldwide, Genetic Home Reference website
329. 47 XYY syndrome 0.05% 1 in 2,000 136,000 1 per 1,000 males are born with 47,XYY syndrome, Genetics Home Reference website
330. Turner Syndrome 0.04% 1 in 2,500 108,800 1 per 2,500 live female births are affected by Turner syndrome, Genetics Home Reference website
331. Autoimmune Lymphoproliferative Syndrome 0.04% 1 in 2,719 100,000 very rare; NIAID mentions 58 individuals
332. Neonatal lupus 0.04% 1 in 2,719 100,000 very rare
333. Androgen Insensitivity Syndrome 0.04% 1 in 2,719 100,000 very rare
334. Porencephaly 0.04% 1 in 2,719 100,000 extremely rare
335. Schizencephaly 0.04% 1 in 2,719 100,000 extremely rare
336. Retinitis Pigmentosa 0.04% 1 in 2,719 100,000 100,000 people have retinitis pigmentosa which can cause retinal deterioration and blindness in the US (Research to Prevent Blindness, NISE, NSF)
337. Neurofibromatosis-1 0.03% 1 in 3,000 90,666 1 per 3,000 - 4,000 people suffer from neurofibromatosis type 1 worldwide, Genetics Home Reference website
338. Congenital hypothyroidsim 0.03% 1 in 3,000 90,666 1 per 3,000 - 4,000 newborns are affected by congenital hypothyroidsim in North America, Europe, Japan and Australia, Genetics Home Reference website
339. Vagina cancer 0.03% 1 in 3,333 81,600 3 in 10,000 for DES-related cases of vaginal cancer.
340. Diethylstilbestrol 0.03% 1 in 3,333 81,600 3 per 10,000 with a risk of vaginal cancer; probably higher if include other complications of DES
341. Muscular dystrophy, Duchenne and Becker type 0.03% 1 in 3,500 77,714 1 per 3,500 - 5,000 male newborns suffer from muscular dystrophy, Duchenne and Becker types, Genetics Home Reference website
342. Hereditary sensory and autonomic neuropathy 3 0.03% 1 in 3,700 73,513 estimated 1 per 3,700 people of Ashkenazi Jewish ancestry suffer from familial dysautonomia, Genetics Home Reference website
343. Familial emphysema 0.03% 1 in 3,885 70,000 70,000 Americans
344. Chromosome 22q11.2 deletion syndrome 0.03% 1 in 4,000 68,000 estimated 1 per 4,000 newborns are affected by chromosome 22q11.2 deletion syndrome, Genetics Home Reference website
345. Multiple Myeloma 0.02% 1 in 4,317 63,000 about 63,000 people affected by multiple myeloma ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
346. Primary Glomerulonephritis 0.02% 1 in 4,428 61,422 61,423 people with Primary Glomerulonephritis in the USA 1996 1
347. IgA nephropathy 0.02% 1 in 4,428 61,422 61,423 people in the USA 1996 1
348. Edwards Syndrome 0.02% 1 in 5,000 54,400 1 per 5,000 - 6,000 newborns are affected by Trisomy 18, Genetics Home Reference website
349. Sarcoidosis 0.02% 1 in 5,000 54,400 20 per 100,000 overall; 5 in 100,000 white people; 40 out of 100,000 black people; Scandinavia 64 out of 100,000 people
350. Marfan syndrome 0.02% 1 in 5,000 54,400 1 per 5,000 people are affected by Marfan syndrome worldwide, Genetics Home Reference website
351. Alpha 1-Antitrypsin Deficiency 0.02% 1 in 5,000 54,400 1 per 5,000 - 7,000 people suffer from alpha-1 antitrypsin deficiency in North America, Genetics Home Reference website
352. Hereditary hemorrhagic telangiectasia 0.02% 1 in 5,000 54,400 estimated 1 per 5,000 - 10,000 people suffer from hereditary hemorrhagic telangiectasia worldwide, Genetics Home Reference website
353. Cardiomyopathy 0.02% 1 in 5,439 50,000 50,000 Americans (NHLBI)
354. Spinal Muscular Atrophy 0.02% 1 in 6,000 45,333 1 per 6,000 - 10,000 people suffer from spinal muscular atrophy, Genetics Home Reference website
355. Dentinogenesis 0.02% 1 in 6,000 45,333 estimated 1 per 6,000 - 8,000 people suffer from dentinogenesis imperfecta, Genetics Home Reference website
356. Canavan disease 0.02% 1 in 6,400 42,500 1 per 6,400 - 13,500 people of Ashkenazi Jewish heritage suffer from Canavan disease, Genetics Home Reference website
357. Neonatal Respiratory Distress Syndrome 0.01% 1 in 6,800 40,000 40,000 infants and 150,000 adults with adult RDS (NHLBI)
358. Romano-Ward syndrome 0.01% 1 in 7,000 38,857 estimated 1 per 7,000 people suffer from Romano-Ward syndrome worldwide, Genetics Home Reference website
359. Williams Syndrome 0.01% 1 in 7,500 36,266 estimated 1 per 7,500 - 20,000 people suffer from Williams syndrome, Genetics Home Reference website
360. Stickler Syndrome 0.01% 1 in 7,500 36,266 estimated 1 per 7,500 - 9,000 newborns suffer from Stickler syndrome, Genetics Home Reference website
361. Tuberous sclerosis 0.01% 1 in 10,000 27,200 less than 1 in 10,000
362. Prader-Willi syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 25,000 people suffer from Prader-Willi syndrome, Genetics Home Reference website
363. Phenylketonuria 0.01% 1 in 10,000 27,200 1 per 10,000 - 15,000 newborns are diagnosed with phenylketonuria in the US, Genetics Home Reference website
364. Rett's syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 22,000 females suffer from Rett syndrome, Genetics Home Reference website
365. Cornelia de Lange Syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 30,000 newborns suffer from Cornelia de Lange syndrome, Genetics Home Reference website
366. Cystinuria 0.01% 1 in 10,000 27,200 approximately 1 per 10,000 people are affected by cystinuria, Genetics Home Reference website
367. Chromosome 13 trisomy syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 newborns are affected by Trisomy 13, Genetics Home Reference website
368. Congenital myopathy 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 people from Scandinavia suffer from myotonia congenita worldwide, Genetics Home Reference website
369. Blue-yellow color vision defects 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 people suffer from blue-yellow color vision defects worldwide, Genetics Home Reference website
370. 2-methylglutaconic aciduria type 3 0.01% 1 in 10,000 27,200 1 per 10,000 newborns from Iraqi Jewish populations suffer from 2-methylglutaconic aciduria type 3, Genetics Home Reference website
371. Waardenburg syndrome 0.01% 1 in 10,000 27,200 estimated 1 per 10,000 - 20,000 people suffer from Waardenburg syndrome, Genetics Home Reference website
372. Angelman syndrome 0.01% 1 in 12,000 22,666 1 per 12,000 - 20,000 people are affected by Angelman syndrome, Genetics Home Reference website
373. Adrenal hypoplasia congenital, X-linked 0.01% 1 in 12,500 21,760 1 per 12,500 newborns suffer from adrenal hypoplasia congenita in the US, Genetics Home Reference website
374. Uterine Cancer 0.01% 1 in 13,333 20,400 4,500 women in the UK 2001 (National Statistics, UK Government Census, 2001)
375. Hemophilia 0.01% 1 in 13,600 20,000 20,000 people in the United States (NHLBI)
376. Amelogenesis Imperfecta 0.01% 1 in 14,000 19,428 estimated 1 per 14,000 people suffer from amelogenesis imperfecta in the US, Genetics Home Reference website
377. Coffin-Lowry syndrome 0.01% 1 in 14,285 19,040 estimated 7 per 100,000 people have Coffin-Lowry syndrome in western Europe and North America, Genetics Home Reference website
378. Smith-Magenis Syndrome 0.01% 1 in 15,000 18,133 1 per 15,000 undiagnosed and diagnosed people are affected by Smith-Magenis syndrome worldwide , Genetics Home Reference website
379. Hypochondroplasia 0.01% 1 in 15,000 18,133 estimated 1 per 15,000 - 40,000 newborns suffer from hypochondroplasia, Genetics Home Reference website
380. Fragile-X Syndrome 0.01% 1 in 16,000 17,000 approximately 1 per 8,000 females suffer from fragile X syndrome, Genetics Home Reference website
381. Osteogenesis imperfecta 0.01% 1 in 16,666 16,320 6-7 per 100,000 people are affected by osteogenesis imperfecta worldwide, Genetics Home Reference website
382. Usher Syndrome 0.01% 1 in 17,000 16,000 16,000 Americans
383. Medium-Chain Acyl-CoA Dehydrogenase Deficiency 0.01% 1 in 17,000 16,000 1 per 17,000 people suffer from medium-chain acyl-CoA dehydrogenase deficiency in the US, Genetics Home Reference website
384. Alkaptonuria 0.01% 1 in 19,000 14,315 1 per 19,000 people suffer from alkaptonuria in parts of Slovakia, Genetics Home Reference website
385. Myasthenia Gravis 0.00% 1 in 20,000 13,600 about 5 per 100,000 to 14 per 100,000 (NWHIC)
386. Adrenoleukodystrophy 0.00% 1 in 20,000 13,600 1 per 20,000 people suffer from X-linked adrenoleukodystrophy, Genetics Home reference website
387. Autosomal Recessive Polycystic Kidney Disease 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 people suffer from the autosomal recessive type of polycystic kidney disease, Genetics Home Reference website
388. Werner syndrome 0.00% 1 in 20,000 13,600 1 per 20,000 - 40,000 people suffer from Werner syndrome in Japan, Genetics Home Reference website
389. Smith-Lemli-Opitz Syndrome 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 newborns suffer from Smith-Lemli-Opitz syndrome, Genetics Home Reference website
390. Alagille Syndrome 0.00% 1 in 20,000 13,600 1 per 20,000 - 70,000 people suffer from Alagille syndrome, Genetics Home Reference website
391. Polycystic kidney disease type 1 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 - 40,000 people are affected by autosomal dominant polycystic kidney disease, Genetics Home Reference website
392. Oculocutaneous albinism 0.00% 1 in 20,000 13,600 estimated 1 per 20,000 people suffer from oculocutaneous albinism, Genetic Home Reference website
393. Thanatophoric dysplasia 0.00% 1 in 20,000 13,600 1 per 20,000 - 50,000 newborns are affected by Thanatophoric dysplasia, Genetics Home Reference website
394. Dermatomyositis 0.00% 1 in 20,205 13,461 13,462 people with polymyositis/dermatomyositis in the USA 1996 1
395. Acromegaly 0.00% 1 in 25,000 10,880 40-60 per million affected people at any time
396. Pseudoxanthoma elasticum 0.00% 1 in 25,000 10,880 1 per 25,000 - 100,000 people are affected by pseudoxanthoma elasticum, Genetics Home Reference website
397. Neurofibromatosis-2 0.00% 1 in 25,000 10,880 1 per 25,000 people suffer from neurofibromatosis type 2, Genetics Home Reference website
398. Usher Syndrome Type 1 0.00% 1 in 25,000 10,880 more than 4 per 100,000 people suffer from Usher syndrome type I, Genetics Home Reference website
399. Cystinosis 0.00% 1 in 26,000 10,461 1 per 26,000 newborns suffer from cystinosis in the Brittany province in France, Genetics Home Reference website
400. Primary biliary cirrhosis 0.00% 1 in 29,462 9,231 9,232 people in the USA 1996 1
401. Wilson's Disease 0.00% 1 in 30,000 9,066 approximately 1 per 30,000 people suffer from Wilson disease, Genetics Home Reference website
402. Muenke Syndrome 0.00% 1 in 30,000 9,066 estimated 1 per 30,000 newborns suffer from Muenke syndrome, Genetics Home Reference website
403. Galactosemia I 0.00% 1 in 30,000 9,066 1 per 30,000 liver births are affected by inherited galactosemia, Genetics Home Reference website
404. Achromatopsia type 1 0.00% 1 in 30,000 9,066 estimated 1 per 30,000 people suffer from complete achromatopsia, Genetics Home Reference website
405. Familial polyposis, autosomal recessive 0.00% 1 in 30,000 9,066 1 per 30,000 people are affected by familial adenomatous polyposis in the US, Genetics Home Reference website
406. Leber hereditary optic neuropathy 0.00% 1 in 30,000 9,066 1 per 30,000 - 50,000 people suffer from Leber hereditary optic neuropathy in northeast England and Finland, Genetics Home Reference website
407. Cystic Fibrosis 0.00% 1 in 31,000 8,774 1 per 31,000 Asian American newborns suffer from cystic fibrosis in the US, genetics Home Reference website
408. Huntington's Disease 0.00% 1 in 33,333 8,160 estimated 3-7 per 100,000 people of European ancestry suffer from Huntington disease, Genetics Home Reference website
409. Multiple endocrine neoplasia type 1 0.00% 1 in 33,333 8,160 3 per 100,000 up to 20 per 100,000 (NIDDK)
410. Osteogenesis imperfecta Type I 0.00% 1 in 33,333 8,160 3-4 per 100,000 people are affected by osteogenesis imperfecta type I worldwide, Genetics Home Reference website
411. Osteogenesis imperfecta type IV 0.00% 1 in 33,333 8,160 3-4 per 100,000 people are affected by osteogenesis imperfecta type IV worldwide, Genetics Home Reference website
412. Ataxia Telangiectasia 0.00% 1 in 40,000 6,800 1 per 40,000 - 100,000 people worldwide suffer from ataxia-telangiectasia, Genetics Home Reference website
413. Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 - 120,000 people suffer from very long-chain acyl-CoA dehydrogenase deficiency, Genetics Home Reference website
414. Short-Chain Acyl-CoA Dehydrogenase Deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 - 100, 000 newborns suffer from short-chain acyl-CoA dehydrogenase deficiency in the US, Genetics Home Reference website
415. Pompe disease 0.00% 1 in 40,000 6,800 1 per 40,000 people suffer from Pompe disease, Genetics Home Reference website
416. Carnitine transporter deficiency 0.00% 1 in 40,000 6,800 1 per 40,000 newborns suffer from primary carnitine deficiency in Japan, Genetics Home Reference website
417. Achondrogenesis 0.00% 1 in 40,000 6,800 1 per 40,000 - 60,000 people are affected by achondrogenesis type 2 and hypochondrogenesis, Genetics Home Reference website
418. Niemann-Pick disease, type A 0.00% 1 in 40,000 6,800 approximately 1 per 40,000 people of Ashkenazi Jewish descent have Niemann-Pick disease type A, Genetics Home Reference website
419. Friedreich ataxia 0.00% 1 in 40,000 6,800 estimated 1 per 40,000 people are affected by Friedreich ataxia, Genetics Home Reference website
420. Bloom Syndrome 0.00% 1 in 48,000 5,666 1 per 48,000 people of Ashkenazi Jewish descent suffer from Bloom syndrome, Genetics Home Reference website
421. Gaucher Disease 0.00% 1 in 50,000 5,440 1 per 50,000 - 100,000 people are affected by Gaucher disease, Genetics Home Reference website
422. Alport Syndrome 0.00% 1 in 50,000 5,440 1 per 50,000 newborns suffer from Alport syndrome, Genetics Home Reference website
423. Treacher-Collins Syndrome 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 people suffer from Treacher Collins syndrome, Genetics Home Reference website
424. Acidemia, methylmalonic 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 - 100,000 suffer from Methylmalonic acidemia, Genetics Home Reference website
425. 3-methylcrotonyl-CoA carboxylase deficiency 0.00% 1 in 50,000 5,440 estimated 1 per 50,000 people suffer from 3-methylcrotonyl-CoA carboxylase deficiency, Genetics Home Reference website
426. Severe combined immunodeficiency, X-linked 0.00% 1 in 50,000 5,440 1 per 50,000 - 100,000 births are affected by X-linked severe combined immunodeficiency, Genetics Home Reference website
427. Hereditary neuropathy with liability to pressure palsies 0.00% 1 in 50,000 5,440 2-5 per 100,000 people suffer from hereditary neuropathy with liability to pressure palsies, Genetics Home Reference website
428. Citrullinemia I 0.00% 1 in 57,000 4,771 1 per 57,000 people have citrullinemia I worldwide , Genetics Home Reference website
429. Autoimmune uveitis 0.00% 1 in 58,658 4,637 4,637 people in the USA 1996 1
430. Biotinidase deficiency 0.00% 1 in 60,000 4,533 about 1 per 60,000 newborns suffer from profound or partial biotinidase deficiency, Genetics Home Reference website
431. Oxalosis, type I 0.00% 1 in 60,000 4,533 estimated 1 per 60,000 - 120,000 births are affected by primary hyperoxaluria, type I, Genetics Home Reference website
432. Ellis-van Creveld syndrome 0.00% 1 in 60,000 4,533 1 per 60,000 - 200,000 newborns are affected by Ellis-van Creveld syndrome worldwide, Genetics Home Reference website
433. Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency 0.00% 1 in 62,000 4,387 estimated 1 per 62,000 people suffer from long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency in Finland, Genetics Home Reference website
434. Corneal Dystrophies 0.00% 1 in 64,761 4,200 4,200 people have reduced vision because of corneal dystrophies in the US (Research to Prevent Blindness, NISE, NSF)
435. Ornithine transcarbamylase (OTC) Deficiency 0.00% 1 in 80,000 3,400 estimated 1 per 80,000 people suffer fro ornithine transcarbamylase deficiency, Genetics Home Reference website
436. Holocarboxylase synthetase deficiency 0.00% 1 in 87,000 3,126 estimated 1 per 87,000 people are affected by holocarboxylase synthetase deficiency, Genetics Home Reference website
437. Amyloidosis 0.00% 1 in 90,666 3,000 less than 3,000 people in the US (Mayo Clinic)
438. Addison's Disease 0.00% 1 in 100,000 2,720 1 in 100,000; 13,335 people in the USA 1996 1
439. Guillain-Barre Syndrome 0.00% 1 in 100,000 2,720 about 1 in 100,000 (NWHIC)
440. X-Linked Agammaglobulinemia 0.00% 1 in 100,000 2,720 1-in-100,000
441. Menkes Disease 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer Menkes syndrome, Genetics Home Reference website
442. Hypokalemic periodic paralysis 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from hypokalemic periodic paralysis, Genetics Home Reference website
443. Apert syndrome 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from Apert syndrome, Genetics Home Reference website
444. Pfeiffer syndrome 0.00% 1 in 100,000 2,720 1 per 100,000 people suffer from Pfeiffer syndrome, Genetics Home Reference website
445. Rubinstein-Taybi Syndrome 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 - 125,000 newborns suffer from Rubinstein-Taybi syndrome, Genetics Home Reference website
446. Holt-Oram Syndrome 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer from Holt-Oram disease, Genetics Home Reference website
447. Diastrophic dysplasia 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 newborns are affected by diastrophic dysplasia, Genetics Home Reference website
448. Krabbe leukodystrophy 0.00% 1 in 100,000 2,720 1 per 100,000 people are affected by Krabbe disease in the US, Genetics Home Reference website
449. Gaucher disease type 3 0.00% 1 in 100,000 2,720 less than 1 per 100,000 births are affected by Gaucher disease type 3, Genetics Home Reference website
450. Emery-Dreifuss muscular dystrophy, X-linked 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 people suffer from X-linked Emery-Dreifuss muscular dystrophy, Genetics Home Reference website
451. Citrullinemia II 0.00% 1 in 100,000 2,720 1 per 100,000 - 230,000 people have citrullinemia II in Japan , Genetics Home Reference website
452. Paramyotonia congenita 0.00% 1 in 100,000 2,720 less than 1 per 100,000 people are affected by paramyotonia congenital, Genetics Home Reference website
453. Porphyria cutanea tarda, familial type 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by porphyria cutanea tarda, Genetics Home Reference website
454. Osteogenesis imperfecta type IIII 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by osteogenesis imperfecta type IIII worldwide, Genetics Home Reference website
455. Osteogenesis imperfecta type II 0.00% 1 in 100,000 2,720 1-2 per 100,000 people are affected by osteogenesis imperfecta type II worldwide, Genetics Home Reference website
456. Klinefelter syndrome variant 0.00% 1 in 100,000 2,720 1 per 50,000 males are affected by Klinefelter syndrome variants, Genetics Home Reference website
457. Propionic academia 0.00% 1 in 100,000 2,720 estimated 1 per 100,000 live births suffer from propionic academia in the US, Genetics Home Reference website
458. Niemann-Pick disease, type C2 0.00% 1 in 150,000 1,813 approximately 1 per 150,000 people have Niemann-Pick disease type C, Genetics Home Reference website
459. Cri-du-chat syndrome 0.00% 1 in 200,000 1,360 1 per 200,000-500,000 newborns are affected by Cri-du-chat syndrome, Genetics Home Reference website
460. Hyperkalemic periodic paralysis 0.00% 1 in 200,000 1,360 1 per 200,000 people are affected by hyperkalemic periodic paralysis, Genetics Home Reference website
461. Homocystinuria 0.00% 1 in 200,000 1,360 at least 1 per 200,000 - 335,000 people are affected by homocystinuria worldwide, Genetics Home Reference website
462. Jervell and Lange-Nielsen Syndrome 0.00% 1 in 200,000 1,360 at least 1 per 200,00 people suffer from Jervell and Lange-Nielsen syndrome in Denmark, Genetics Home Reference website
463. Cowden's syndrome 0.00% 1 in 200,000 1,360 estimated 1 per 200,000 people are affected by Cowden's syndrome, Genetic Home Reference website
464. Autoimmune Hepatitis 0.00% 1 in 235,294 1,156 1,156 people in the USA 1996 1
465. Amyotrophic lateral sclerosis 0.00% 1 in 250,000 1,087 4-8 per 1000,000 people suffer from amyotrophic lateral sclerosis worldwide, Genetics Home Reference website
466. Ehlers-Danlos syndrome 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 people suffer from the vascular type of Ehlers-Danlos syndrome, Genetics Home Reference website
467. Peutz-Jeghers Syndrome 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 - 300,000 people suffer from Peutz-Jeghers syndrome, Genetics Home Reference website
468. Oculocutaneous tyrosinemia 0.00% 1 in 250,000 1,087 1 per 250,000 people suffer from tyrosinemia type 2, Genetics Home Reference website
469. Pyruvate carboxylase deficiency 0.00% 1 in 250,000 1,087 estimated 1 per 250,000 births are affected by pyruvate carboxylase deficiency, Genetics Home Reference website
470. Isovaleric academia 0.00% 1 in 250,000 1,087 1 per 250,000 births are affected by isovaleric academia in the US, Genetics Home Reference website
471. Thalassemia 0.00% 1 in 272,000 1,000 1,000 people with Cooley's anemia (NHLBI)
472. Secondary pulmonary hypertension 0.00% 1 in 272,000 1,000 about 1,000 new cases of pulmonary arterial hypertension are diagnosed each year in the US, Genetics Home Reference website
473. Arginase deficiency 0.00% 1 in 300,000 906 estimated 1 per 300,000 - 1,000,000 people suffer from arginase deficiency, Genetics Home Reference website
474. Lesch-Nyhan syndrome 0.00% 1 in 380,000 715 1 per 380,000 people are affected by Lesch-Nyhan syndrome worldwide, Genetics Home Reference website
475. Incontinentia Pigmenti 0.00% 1 in 388,571 700 700 - 1,000 cases of incontinentia pigmenti have been reported, Genetics Home Reference website
476. Barth Syndrome 0.00% 1 in 400,000 680 1 per 200,000 male infants suffer from 2-methylglutaconic aciduria type 2, Genetics Home Reference website
477. Cryptococcosis 0.00% 1 in 500,000 544 0.2-0.9 cases per 100,000 in the general population (DBMD)
478. SCID 0.00% 1 in 500,000 543 approximately 1-per-500,000 (NIDCD); 1-per-million
479. Cushing's syndrome 0.00% 1 in 500,000 543 2-5 per million (NIDCD); 10 per million; 10-15 per million
480. Gaucher disease type 2 0.00% 1 in 500,000 543 less than 1 per 500,000 births are affected by Gaucher disease type 2, Genetics Home Reference website
481. Lymphangioleiomyomatosis 0.00% 1 in 544,000 500 Several hundred people in the USA (NHLBI)
482. Carbamoyl-phosphate synthase 1 deficiency 0.00% 1 in 800,000 340 estimated 1 per 800,000 newborns suffer from carbamoyl phosphate synthetase I deficiency in Japan, Genetics Home Reference website
483. Familial hyperchylomicronemia 0.00% 1 in 1 million 271 1 per 1 million suffer from familial lipoprotein lipase deficiency worldwide, Genetics Home Reference website
484. Crouzonodermoskeletal syndrome 0.00% 1 in 1 million 271 1 per 1 million people are affected by Crouzonodermoskeletal syndrome, Genetics Home Reference website
485. Pantothenate kinase-associated neurodegeneration 0.00% 1 in 1 million 271 estimated 1-3 per 1 million people are affected by Hallervorden-Spatz disease worldwide, Genetics Home Reference website
486. Homozygous Familial Hypercholesterolemia 0.00% 1 in 1 million 271 1 per 1 million US people suffer from Homozygous familial hypercholesterolemia.
487. Mucopolysaccharidosis type I Hurler-Scheie syndrome 0.00% 1 in 1.4 million 200 about 200 people ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
488. Myositis ossificans 0.00% 1 in 2 million 135 estimated 1 per 2 million people are affected by fibrodysplasia ossificans progressiva, Genetics Home Reference website
489. Glucagonoma 0.00% 1 in 2.7 million 100 only 100 cases since 1974 (Ganda, 1997)
490. POEMS 0.00% 1 in 2.7 million 100 about 100 known cases (Ganda [1997])
491. Chronic Granulomatous Disease 0.00% 1 in 4 million 67 1-in-4 million to 5 million (NIAID)
492. Beta ketothiolase deficiency 0.00% 1 in 5.4 million 49 50 - 60 cases of beta-ketothiolase deficiency have been reported worldwide, Genetics Home Reference website
493. Rheumatic conditions 0.00% 1 in 6.3 million 43 nearly 43 Americans have arthritis or a rheumatic disease (CDC); 40 million people in the United States (NIAMS)
494. Carnitine-acylcarnitine translocase deficiency 0.00% 1 in 9.1 million 29 about 30 cases of carnitine-acylcarnitine translocase deficiency have been confirmed, Genetics Home Reference website
495. Short QT syndrome 0.00% 1 in 9.1 million 29 less than 30 cases of short QT syndrome have been reported, Genetics Home Reference website
496. X-linked sideroblastic anemia 0.00% 1 in 12 million 22 several hundred cases of X-linked sideroblastic anemia have been reported worldwide, Genetics Home Reference website
497. Somatostatinoma 0.00% 1 in 13.6 million 20 20 known cases in the literature (Ganda, 1997)
498. Malonic aciduria 0.00% 1 in 13.6 million 20 less than 20 cases of malonic aciduria have been reported, Genetics Home Reference website
499. 3-methylglutaconic aciduria, type 1 0.00% 1 in 13.6 million 20 less than 20 cases of 2-methylglutaconic aciduria type 1 have been reported, Genetics Home Reference website
500. Alstrom disease 0.00% 1 in 14.1 million 19 about 425 cases of Alstrom disease reported worldwide, Genetics Home Reference website
501. Cadasil 0.00% 1 in 15 million 18 about 400 people have been diagnosed with CADASIL worldwide, Genetics Home Reference website
502. Isobutyryl-coenzyme A dehydrogenase deficiency 0.00% 1 in 54.4 million 5 less than 5 cases of isobutyryl-coenzyme A dehydrogenase deficiency have been reported, Genetics Home Reference website
503. HMG-CoA lyase deficiency 0.00% 1 in 60 million 4 less than 100 people have been diagnosed with HMG-CoA lyase deficiency worldwide, Genetics Home Reference website
504. Andersen-Tawil syndrome 0.00% 1 in 60 million 4 100 people have been reported with Andersen-Tawil syndrome worldwide, Genetics Home Reference
505. Tangier disease 0.00% 1 in 120 million 2 about 50 cases of Tangier disease have been diagnosed worldwide, Genetics Home Reference website
506. Carnitine palmitoyl transferase 1 deficiency 0.00% 1 in 120 million 2 less than 50 people suffer from Jervell and Lange-Nielsen syndrome worldwide, Genetics Home Reference website
507. Ethylmalonic aciduria 0.00% 1 in 200 million 1 about 30 cases of ethylmalonic encephalopathy have been reported worldwide, Genetics Home Reference website
508. Pseudotumor Cerebri 0.00% 1 in 272 million 1 about 1-2 people per 100,000 population have benign intracranial hypertension in the US (Association for Spina Bifida and Hydrocephalus)


Footnotes:
1. Rose and Mackay, 1998, The Autoimmune Diseases, Third Edition
 

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