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Diseases » Machado-Joseph Disease » Inheritance
 

Inheritance and Genetics of Machado-Joseph Disease

Inheritance of Machado-Joseph Disease:

Autosomal dominant diseases are usually inherited from the one parent who already has the disease. Rare cases of sporadic genetic disease with neither parent having the disease can also occur. See inheritance of autosomal dominant diseases.

Genetics of Machado-Joseph Disease:

Machado-Joseph disease is inherited in an autosomal dominant manner. The signs and symptoms of the disease usually get worse as the disease is passed from one generation to the next.

Machado-Joseph Disease: Inheritance and Genetics Details

Inheritance properties of Machado-Joseph Disease:

  Disease inherited from: Usually inherited from one parent who has Machado-Joseph Disease; see inheritance of autosomal dominant diseases.

  Gender bias in inheritance: Male and female children are equally at risk of autosomal dominant diseases.

Inheritance Patterns

Inheritance odds for Machado-Joseph Disease:

  Overall odds of inheritance: Usually inherited from one parent who has Machado-Joseph Disease; see inheritance of autosomal dominant diseases.

  Sibling of diseased child odds of inheriting disease: Usually 50% for autosomal dominant diseases.

  Overall odds of inheriting from mother: Usually 50% for autosomal dominant diseases.

  Overall odds of inheriting from father: Usually 50% for autosomal dominant diseases.

  Mother to son inheritance odds: Usually 50% for autosomal dominant diseases.

  Father to son inheritance odds: Usually 50% for autosomal dominant diseases.

  Mother to daughter inheritance odds: Usually 50% for autosomal dominant diseases.

  Father to daughter inheritance odds: Usually 50% for autosomal dominant diseases.

  Inheritance from one diseased parent odds: Usually 50% for autosomal dominant diseases.

  Inheritance from two diseased parents odds: Usually 75% (50% disease, 25% double dominant) for autosomal dominant diseases.

Genetic Carriers

Genetic carriers of Machado-Joseph Disease:

  Carriers possible for disease?: No, not for autosomal dominant diseases.

  Odds daughter becomes genetic carrier: 0%. There are no carriers for autosomal dominant diseases.

  Odds son becomes genetic carrier: 0%. There are no carriers for autosomal dominant diseases.

Inheritance Features

Inheritance features for Machado-Joseph Disease:

  Inheritance pattern: Vertical inheritance for autosomal dominant disease.

  Sporadic form of disease possible?: Yes, only one genetic mutation is required for a sporadic version of an autosomal dominant disease.

  Double dominant form of disease possible?: Yes, double dominance is definitely applicable for autosomal dominance.

  Inheritance from one double dominant parent: Usually 100% inheritance from a double dominant form of an autosomal dominant disease.

Machado-Joseph Disease: Genetics Information

Genetics of Machado-Joseph Disease: MJD is an inherited, autosomal dominant disease, meaning that if a child inherits one copy of the defective gene from either parent, the child will develop symptoms of the disease. People with a defective gene have a 50 percent chance of passing the mutation on to their children. (Source: excerpt from NINDS Machado-Joseph Disease Information Page: NINDS)

About inheritance and genetics:

Inheritance of Machado-Joseph Disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

 

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