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Treatments for Mesangial proliferative glomerulonephritis

Treatment List for Mesangial proliferative glomerulonephritis

The list of treatments mentioned in various sources for Mesangial proliferative glomerulonephritis includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.

  • Treatment of mesangial proliferative glomerulonephritis is dependant upon the cause of the disease, whether it is acute or chronic, the severity of renal impairment, as well as the age and comorbidities of the patient. Treatments include:
    • Antibiotics - for disease associated with infection
    • Corticosteroids - Pulse steroids followed by maintenance treatment
    • Immunosuppressants - cyclophosphamide, azathioprine
    • Fish oil - for progressive IgA nephropathy
    • Antihypertensives - for management of high blood pressure, both in the acute and chronic phase
    • Fluid restriction - for significant oedema
    • Diuretics - for fluid overload
    • Avoidance of medications that may contribute to further renal damage - NSAID's, IV contrast
    • Renal dialysis - may be required for severe renal failure in the acute phase, or chronic renal failure
    • Dietary management depending on the severity of renal impairment
      • Protein management - depends on the amount of protein lost in the urine and the degree of renal failure
      • Salt and water restriction as necessary to manage fluid overload
      • Phosphate restriction
      • Potassium restriction as necessary
    • Management of chronic renal failure as required
      • Erythropoietin agonists - for management of anaemia associated with chronic renal failure
      • Phosphate binders - for management of hyperphosphatemia in chronic renal failure
      • Calcium supplements - for hypocalcaemia associated with chronic renal failure
      • Calcitriol and other Vitamin D supplements - for hypocalcaemia and hyperparathyroidism associated with chronic renal failure
      • Sodium bicarbonate - for acid-base disturbance
      • Renal dialysis - used when there are manifestations of uraemia and the GFR is < 10mL/min
      • Renal transplantation

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