Clinical Trials for Migraine

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Migraine is grouped into the following categories:-

• View by trial name
• View by drugs used in Migraine clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Migraine:

• Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - AST-726 Low dose,AST-726 High dose,AST-726 Placebo
• A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate,propranolol
• Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. - This study is currently recruiting patients (Current: 23 Nov 2006) - Topiramate
• Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - topiramate; almotriptan malate
• A 1-Year Study in Adolescents to Assess the Long-Term Safety of Almotriptan Malate When Treating Their Migraine Headaches - This study is currently recruiting patients (Current: 23 Nov 2006) - almotriptan malate
• Evaluation of the Efficacy and Safety of Laxymig as Prophylactic Treatment in Patients With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Laxymig ER (drug)
• Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006) - Dronabinol MDI
• Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006) - Tonabersat
• Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. - This study has been completed (Current: 23 Nov 2006) - CGRP
• Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine - This study has been completed (Current: 23 Nov 2006) - Topiramate
• A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Topiramate
• Study With Migraid Device in Acute, Early Treatment of Migraine With Typical Aura - This study has been completed (Current: 23 Nov 2006)
• Functional MRI (fMRI) in CGRP Induced Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - infusion of calcitonin gene related peptide (CGRP)
• A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• The Effectiveness and Safety of Topiramate on Prevention of Chronic Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Effectivensss and Safety of Topiramate for the Prevention of Migraine Attacks in Children - This study is currently recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines - This study is currently recruiting patients (Current: 23 Nov 2006) - dexamethasone 10mg IV
• TREXIMA for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1) - This study is currently recruiting patients (Current: 23 Nov 2006) - sumatriptan succinate / naproxen sodium
• The Prolonged Use of Topiramate for Preventing Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006) - Topiramate
• Trexima In The Acute Treatment Of Multiple Migraine Attacks - This study is no longer recruiting patients (Current: 23 Nov 2006) - sumatriptan succinate/naproxen sodium
• An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Efficacy of RWJ-333369 in the Prevention of Migraine - This study has been completed (Current: 23 Nov 2006) - RWJ-333369
• A Study to Measure the Safety and Effectiveness of Zonisamide in Subjects With Migraine Headache - This study has been completed (Current: 23 Nov 2006) - zonisamide
• Migraine and Recurrent Abdominal Pain in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Role of CGRPand Nociceptin in Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• This Phase III, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Multi-Center Study Designed to Evaluate the Safety and Efficacy of Prophylactic Depakote ER in the Treatment of Adolescent Migraine. - This study is currently recruiting patients (Current: 23 Nov 2006) - divalproex sodium
• Study Designed to Evaluate the Safety of Prophylactic Depakote ER in the Treatment of Adolescents With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - divalproex sodium
• A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity - This study has been completed (Current: 23 Nov 2006) - dihydroergotamine mesylate
• Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial. - This study is no longer recruiting patients (Current: 23 Nov 2006) - 17-beta-estradiol (drug)
• Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers - This study is currently recruiting patients (Current: 23 Nov 2006) - almotriptan or pseudoephedrine
• A Study of 3 Dosage Strengths of Aalmotriptan Malate (AXERT) in the Treatment of Acute Migraine in Adolescents - This study is no longer recruiting patients (Current: 23 Nov 2006) - almotriptan malate
• A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine Headache - This study is no longer recruiting patients (Current: 23 Nov 2006) - almotriptan malate
• Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention. - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• An Open Label Extension of a Study of Topiramate in Chronic Migraine. - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• The Effectiveness of Almotriptan Malate (AXERT) 12.5 Milligrams When Taken at the Onset of Migraine Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - almotriptan malate
• Oral Dexamethasone for Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Dexamethasone
• Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain - This study is currently recruiting patients (Current: 23 Nov 2006) - OraVescent Fentanyl
• Study Of Trexima In The Acute Treatment Of Multiple Migraine Attacks - This study is no longer recruiting patients (Current: 23 Nov 2006) - sumatriptan succinate/naproxen sodium
• Use Of GW274150 In The Prophylactic Treatment Of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - GW274150
• Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in Migraineurs - This study has been completed (Current: 23 Nov 2006) - Vasoactive intestinal peptide
• Evaluate Safety/Effectiveness of PFO Closure With the BioSTAR(R) Septal Repair Implant to Resolve Refractory Migraine w/ Aura - This study is currently recruiting patients (Current: 23 Nov 2006)
• Treatment for Migraines With an Implantable Device - This study is currently recruiting patients (Current: 23 Nov 2006)
• Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers? - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Topiramate
• A Study Comparing the Effectiveness and Safety of ULTRACET (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache - This study is no longer recruiting patients (Current: 23 Nov 2006) - tramadol HCl/acetaminophen
• A Quality of Life Study in Patients With Migraines - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy of rTMS in the Treatment of Patients With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack - This study is currently recruiting patients (Current: 23 Nov 2006) - PRO-513
• Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan - This study is currently recruiting patients (Current: 23 Nov 2006) - Sumatriptan Succinate
• Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines? - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Rizatriptan
• A Clinical Trial Comparing Two Different Medications to Determine Which One is Better for Patients With an Acute Migraines in the Emergency Department - This study is currently recruiting patients (Current: 23 Nov 2006) - Prochlorperazine,Metoclopramide
• A Placebo-Controlled Adaptive Treatment Assignment Study of Intravenous COL-144 in the Acute Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - COL-144
• Two Rizatriptan Prescribing Portions for Treatment of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - rizatriptan
• Use Of SB-705498 In The Acute Treatment Of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - SB-705498
• An Adaptive Design Trial Of GW274150 In The Treatment Of Acute Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - GW274150
• Menstrual Migraine Treatment With TREXIMA - This study is currently recruiting patients (Current: 23 Nov 2006) - sumatriptan succinate/naproxen sodium
• TREXIMA For Menstrual Migraine in Women With Dysmenorrhea - This study is currently recruiting patients (Current: 23 Nov 2006) - sumatriptan succinate/naproxen sodium
• Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders. - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Combination Product (sumatriptan succinate / naproxen sodium)
• Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders. - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Combination Product (sumatriptan succinate / naproxen sodium)
• Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches - This study has been terminated (Current: 23 Nov 2006) - NPS 1776
• Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Octreotide
• A Double Blind Randomized Controlled of Placebo and Nebulized Lidocaine for Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006) - Lidocaine
• Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache - This study has been completed (Current: 23 Nov 2006) - Soy Isoflavones
• ESCAPE Migraine Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches - This study is currently recruiting patients (Current: 23 Nov 2006) - Rozerem
• A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches - This study is currently recruiting patients (Current: 23 Nov 2006) - botulinum toxin type A
• Premium Migraine Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cortical Reorganisation in Patients With Primary Headache Disorders - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tonabersat in the Prophylaxis of Migraine With Aura - This study is currently recruiting patients (Current: 23 Nov 2006) - Tonabersat
• PACAP38s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow - This study is currently recruiting patients (Current: 23 Nov 2006) - PACAP38
• A Phase III Open-Label, Multi-Center, Long-Term Extension Study of Depakote ER in Subjects Who Either Completed or Prematurely Discontinued Due to Ineffectiveness From Study M02-488. - This study is currently recruiting patients (Current: 23 Nov 2006) - divalproex sodium
• Psychological Assessment and Treatment of Chronic Benign Headache - This study has been completed (Current: 23 Nov 2006)
• Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - MK0462, rizatriptan benzoate / Duration of Treatment: 1day,Comparator: placebo / Duration of Treatment: 1 day
• Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - MK0462, rizatriptan benzoate / Duration of Treatment: 1day,Comparator: placebo / Duration of Treatment: 1 day
• Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - MK0462, rizatriptan benzoate / Duration of Treatment -1 day,Comparator: placebo / Duration of Treatment - 1 day
• Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - MK0462, rizatriptan benzoate / Duration of Treatment -1day,Comparator: placebo / Duration of Treatment - 1 day
• A Trial to Study of the Effects of Eletriptan 40mg on Mild vs Moderate to Severe Pain Intensity of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006) - eletriptan
• A Clinical Study Examining the Safety and Effectiveness of a New Medication (Keppra) for the Prevention of Migraine Headaches - This study has been completed (Current: 23 Nov 2006) - levetiracetam
• A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache - This study has been completed (Current: 23 Nov 2006) - lidocaine plus bupivicaine,lidocaine plus bupivicaine plus triamcinolone (steroid)
• A Research Study Examining the Use of Olanzapine for the Prevention of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Olanzapine
• Research Study Examining Nerve Block for Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Dose-Finding Study of MK0974 in Acute Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - MK0974
• Study to Test a Marketed Product in the Treatment of Migraine-Associated Nausea - This study is currently recruiting patients (Current: 23 Nov 2006) - MK0462, rizatriptan benzoate / Duration of Treatment One (1) Day,Comparator: placebo / Duration of Treatment One (1) Day
• Zonisamide for Fibromyalgia & Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - zonisamide
• Prospective Survey of Menstrual Migraine & Prevention With Eletriptan - This study is currently recruiting patients (Current: 23 Nov 2006) - eletriptan
• PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006) - PGI2
• A Study to Evaluate the Tolerability of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine. - This study is currently recruiting patients (Current: 23 Nov 2006) - Rizatriptan co-administered with Acetaminophen
• Efficacy and Safety Study of Dysport Used for Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006) - Botulinum toxin type A
• Research Study of Greater Occipital Nerve Block As A Treatment For Prolonged Migraine Attacks - This study is currently recruiting patients (Current: 23 Nov 2006) - 0.5% bupivicaine and 2% lidocaine
• Research Study to Determine Sensitivity to Gentle Touch and Pressure During an Active Migraine Attack. - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Migranal
• A Research Study To Compare Two Kinds Of Daily Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics. - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - GTN,Diamox
• STOP PAIN: Septal Closure of PFO - Does It Prevent Migraine? - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2 - This study is currently recruiting patients (Current: 23 Nov 2006) - PGE2
• Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs - This study is currently recruiting patients (Current: 23 Nov 2006)
• Neuropeptides in the Humane Intra- og Extracerebral Circulation. - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - sumatriptan
• American Migraine Prevention Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine. - This study has been completed (Current: 23 Nov 2006) - Lornoxicam 8 mg,Lornoxicam 16 mg,Placebo
• Dysport In Migraine Without Aura Prophylaxis : DIMWAP Study - This study has been completed (Current: 23 Nov 2006) - Botulinum Toxin type A (Dysport ® ) IM/SC 6-sites pericranial injection
• Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 - This study is currently recruiting patients (Current: 23 Nov 2006) - GTN
• Experimental Headache Induced by Vasoactive Intestinal Polypeptide - This study has been completed (Current: 23 Nov 2006) - VIP
• The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography. - This study has been completed (Current: 23 Nov 2006)
• Efficacy and Safety Study of E2007 in Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006) - E2007
• Efficacy and Safety Study of E2007 in Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006) - E2007
• A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches - This study is currently recruiting patients (Current: 23 Nov 2006) - Botulinum Toxin Type A
• TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine - This study is currently recruiting patients (Current: 23 Nov 2006) - Combination Product (sumatriptan succinate / naproxen sodium),RELPAX(eletriptan) 40mg Tablet
• Treatment of Acute Migraine Headache in Children - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Metoclopramide
• Family Study of Affective and Anxiety Spectrum Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache - This study is currently recruiting patients (Current: 23 Nov 2006) - prednisolone
• Occipital Nerve Stimulation to Treat Chronic Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006)
• An Open-Label Study to Evaluate Topiramate Therapy in Migraine Patients, and Its Effects on Subject Responsiveness to Migraine Treatment With Triptans - This study is no longer recruiting patients (Current: 23 Nov 2006) - topiramate
• Headstrong Intervention for Pediatric Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• Management of Headache Disorders. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prospective ED Headache Cohort Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Non-Implant Method to Close Patent Foramen Ovale (PFO) - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Migraine

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Migraine:

• 0.5% bupivicaine and 2% lidocaine - Research Study of Greater Occipital Nerve Block As A Treatment For Prolonged Migraine Attacks - This study is currently recruiting patients (Current: 23 Nov 2006)
• 17-beta-estradiol (drug) - Treatment of Menstrual Migraine With Sequential, Transdermal, 17-Beta-Estradiol. A Double-Blind, Randomised, Cross-Over Trial. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• AST-726 High dose - Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• AST-726 Low dose - Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• AST-726 Placebo - Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Almotriptan Malate - A 1-Year Study in Adolescents to Assess the Long-Term Safety of Almotriptan Malate When Treating Their Migraine Headaches - This study is currently recruiting patients (Current: 23 Nov 2006)
• Almotriptan Malate - A Study of 3 Dosage Strengths of Aalmotriptan Malate (AXERT) in the Treatment of Acute Migraine in Adolescents - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Almotriptan Malate - A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine Headache - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Almotriptan Malate - The Effectiveness of Almotriptan Malate (AXERT) 12.5 Milligrams When Taken at the Onset of Migraine Pain - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Almotriptan Or Pseudoephedrine - Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Botulinum Toxin Type A - A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches - This study is currently recruiting patients (Current: 23 Nov 2006)
• Botulinum Toxin Type A - A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches - This study is currently recruiting patients (Current: 23 Nov 2006)
• Botulinum Toxin type A (Dysport ® ) IM/SC 6-sites pericranial injection - Dysport In Migraine Without Aura Prophylaxis : DIMWAP Study - This study has been completed (Current: 23 Nov 2006)
• Botulinum toxin type A - Efficacy and Safety Study of Dysport Used for Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• CGRP - Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. - This study has been completed (Current: 23 Nov 2006)
• COL-144 - A Placebo-Controlled Adaptive Treatment Assignment Study of Intravenous COL-144 in the Acute Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Combination Product (sumatriptan succinate / naproxen sodium) - Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Combination Product (sumatriptan succinate / naproxen sodium) - Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Combination Product (sumatriptan succinate / naproxen sodium) - TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparator: placebo / Duration of Treatment One (1) Day - Study to Test a Marketed Product in the Treatment of Migraine-Associated Nausea - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparator: placebo / Duration of Treatment - 1 day - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparator: placebo / Duration of Treatment - 1 day - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparator: placebo / Duration of Treatment: 1 day - Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Comparator: placebo / Duration of Treatment: 1 day - Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Dexamethasone 10Mg Iv - Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - Oral Dexamethasone for Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Diamox - The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Dihydroergotamine Mesylate - A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity - This study has been completed (Current: 23 Nov 2006)
• Divalproex Sodium - A Phase III Open-Label, Multi-Center, Long-Term Extension Study of Depakote ER in Subjects Who Either Completed or Prematurely Discontinued Due to Ineffectiveness From Study M02-488. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Divalproex Sodium - Study Designed to Evaluate the Safety of Prophylactic Depakote ER in the Treatment of Adolescents With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Divalproex Sodium - This Phase III, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Multi-Center Study Designed to Evaluate the Safety and Efficacy of Prophylactic Depakote ER in the Treatment of Adolescent Migraine. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dronabinol MDI - Study to Evaluate the Efficacy and Safety of Dronabinol Metered Dose Inhaler (MDI) in Acute Treatment of Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• E2007 - Efficacy and Safety Study of E2007 in Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• E2007 - Efficacy and Safety Study of E2007 in Migraine Prophylaxis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Eletriptan - A Trial to Study of the Effects of Eletriptan 40mg on Mild vs Moderate to Severe Pain Intensity of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Eletriptan - Prospective Survey of Menstrual Migraine & Prevention With Eletriptan - This study is currently recruiting patients (Current: 23 Nov 2006)
• GTN - Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 - This study is currently recruiting patients (Current: 23 Nov 2006)
• GTN - The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• GW274150 - An Adaptive Design Trial Of GW274150 In The Treatment Of Acute Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW274150 - Use Of GW274150 In The Prophylactic Treatment Of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Infusion Of Calcitonin Gene Related Peptide (Cgrp) - Functional MRI (fMRI) in CGRP Induced Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Laxymig ER (drug) - Evaluation of the Efficacy and Safety of Laxymig as Prophylactic Treatment in Patients With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levetiracetam - A Clinical Study Examining the Safety and Effectiveness of a New Medication (Keppra) for the Prevention of Migraine Headaches - This study has been completed (Current: 23 Nov 2006)
• Lidocaine Plus Bupivicaine Plus Triamcinolone (Steroid) - A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache - This study has been completed (Current: 23 Nov 2006)
• Lidocaine Plus Bupivicaine - A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache - This study has been completed (Current: 23 Nov 2006)
• Lidocaine - A Double Blind Randomized Controlled of Placebo and Nebulized Lidocaine for Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lornoxicam 16 mg - Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine. - This study has been completed (Current: 23 Nov 2006)
• Lornoxicam 8 mg - Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine. - This study has been completed (Current: 23 Nov 2006)
• MK0462, rizatriptan benzoate / Duration of Treatment -1 day - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• MK0462, rizatriptan benzoate / Duration of Treatment -1day - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• MK0462, rizatriptan benzoate / Duration of Treatment One (1) Day - Study to Test a Marketed Product in the Treatment of Migraine-Associated Nausea - This study is currently recruiting patients (Current: 23 Nov 2006)
• MK0462, rizatriptan benzoate / Duration of Treatment: 1day - Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• MK0462, rizatriptan benzoate / Duration of Treatment: 1day - Study to Test an Approved Product in the Early Treatment of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• MK0974 - A Dose-Finding Study of MK0974 in Acute Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metoclopramide - A Clinical Trial Comparing Two Different Medications to Determine Which One is Better for Patients With an Acute Migraines in the Emergency Department - This study is currently recruiting patients (Current: 23 Nov 2006)
• Metoclopramide - Treatment of Acute Migraine Headache in Children - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Migranal - A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• NPS 1776 - Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches - This study has been terminated (Current: 23 Nov 2006)
• Octreotide - Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Olanzapine - A Research Study Examining the Use of Olanzapine for the Prevention of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• OraVescent Fentanyl - Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
• PACAP38 - PACAP38s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow - This study is currently recruiting patients (Current: 23 Nov 2006)
• PGE2 - Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2 - This study is currently recruiting patients (Current: 23 Nov 2006)
• PGI2 - PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
• PRO-513 - An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Study of Lornoxicam or Placebo for Acute Treatment of the Headache of Migraine. - This study has been completed (Current: 23 Nov 2006)
• Prednisolone - Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prochlorperazine - A Clinical Trial Comparing Two Different Medications to Determine Which One is Better for Patients With an Acute Migraines in the Emergency Department - This study is currently recruiting patients (Current: 23 Nov 2006)
• Propranolol - A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• RELPAX(eletriptan) 40mg Tablet - TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• RWJ-333369 - A Study of the Efficacy of RWJ-333369 in the Prevention of Migraine - This study has been completed (Current: 23 Nov 2006)
• Rizatriptan co-administered with Acetaminophen - A Study to Evaluate the Tolerability of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rizatriptan - Does a Migraine Medication Decrease Rotational Motion Sickness in People Suffering From Migraines? - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Rizatriptan - Two Rizatriptan Prescribing Portions for Treatment of Migraine - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Rozerem - A Double-Blind Placebo-Controlled Trial of Rozerem in Migraine Headaches - This study is currently recruiting patients (Current: 23 Nov 2006)
• SB-705498 - Use Of SB-705498 In The Acute Treatment Of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Soy Isoflavones - Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache - This study has been completed (Current: 23 Nov 2006)
• Sumatriptan Succinate / Naproxen Sodium - TREXIMA for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sumatriptan Succinate/Naproxen Sodium - Menstrual Migraine Treatment With TREXIMA - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sumatriptan Succinate/Naproxen Sodium - Study Of Trexima In The Acute Treatment Of Multiple Migraine Attacks - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sumatriptan Succinate/Naproxen Sodium - TREXIMA For Menstrual Migraine in Women With Dysmenorrhea - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sumatriptan Succinate/Naproxen Sodium - Trexima In The Acute Treatment Of Multiple Migraine Attacks - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sumatriptan Succinate - Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sumatriptan - Neuropeptides in the Humane Intra- og Extracerebral Circulation. - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Tonabersat - Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tonabersat - Tonabersat in the Prophylaxis of Migraine With Aura - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Effectivensss and Safety of Topiramate for the Prevention of Migraine Attacks in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate - An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - An Open Label Extension of a Study of Topiramate in Chronic Migraine. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - An Open-Label Study to Evaluate Topiramate Therapy in Migraine Patients, and Its Effects on Subject Responsiveness to Migraine Treatment With Triptans - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers? - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Topiramate - Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine - This study has been completed (Current: 23 Nov 2006)
• Topiramate - Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topiramate - The Effectiveness and Safety of Topiramate on Prevention of Chronic Migraine - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate - The Prolonged Use of Topiramate for Preventing Migraine Headaches - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Topiramate; Almotriptan Malate - Potential Impact (Benefit) of Preventative Treatment With Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tramadol Hcl/Acetaminophen - A Study Comparing the Effectiveness and Safety of ULTRACET (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache - This study is no longer recruiting patients (Current: 23 Nov 2006)
• VIP - Experimental Headache Induced by Vasoactive Intestinal Polypeptide - This study has been completed (Current: 23 Nov 2006)
• Vasoactive intestinal peptide - Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in Migraineurs - This study has been completed (Current: 23 Nov 2006)
• Zonisamide - A Study to Measure the Safety and Effectiveness of Zonisamide in Subjects With Migraine Headache - This study has been completed (Current: 23 Nov 2006)
• Zonisamide - Zonisamide for Fibromyalgia & Migraine - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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