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What is Morquio syndrome, type B?

What is Morquio syndrome, type B?

  • Morquio syndrome, type B: A rare inherited biochemical disorder characterized by the accumulation of mucopolysaccharides (glycosaminoglycans) in various body tissues due to insufficient amounts of the enzyme (? galactosidase) needed to break it down.
  • Morquio syndrome, type B: A ganglioside storage disorder due to beta-galactosidase (EC 3.2.1.23) deficiency and abnormal accumulation of GM1 ganglioside in neurons and in hepatic, splenic and other histiocytes and in renal glomerular epithelium due. The symptoms appear shortly after birth; they include retarded psychomotor development, failure to thrive, startle reaction to sounds, feeding difficulty, hepatosplenomegaly, Hurler (gargoyle-like) facies (coarse facial features, macrocephaly, broad nose, frontal bossing, long philtrum, prominent maxilla, and macroglossia), bone defects similar to those seen in Hurler syndrome (mainly dysostosis multiplex and long bone and vertebral anomalies), and other abnormalities. Severe cerebral degeneration follows with death in the first two years of life usually due to bronchopneumonia. The affected infants are often blind, deaf, and quadriplegic.
    Source - Diseases Database

Morquio syndrome, type B is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Morquio syndrome, type B, or a subtype of Morquio syndrome, type B, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Morquio syndrome, type B: Introduction

Types of Morquio syndrome, type B:

Broader types of Morquio syndrome, type B:

How serious is Morquio syndrome, type B?

Complications of Morquio syndrome, type B: see complications of Morquio syndrome, type B

What causes Morquio syndrome, type B?

Causes of Morquio syndrome, type B: see causes of Morquio syndrome, type B

What are the symptoms of Morquio syndrome, type B?

Symptoms of Morquio syndrome, type B: see symptoms of Morquio syndrome, type B

Complications of Morquio syndrome, type B: see complications of Morquio syndrome, type B

Can anyone else get Morquio syndrome, type B?

More information: see contagiousness of Morquio syndrome, type B
Inheritance: see inheritance of Morquio syndrome, type B

Morquio syndrome, type B: Testing

Misdiagnosis: see misdiagnosis and Morquio syndrome, type B.

How is it treated?

Doctors and Medical Specialists for Morquio syndrome, type B: Medical Geneticist ; see also doctors and medical specialists for Morquio syndrome, type B.
Treatments for Morquio syndrome, type B: see treatments for Morquio syndrome, type B

Name and Aliases of Morquio syndrome, type B

Main name of condition: Morquio syndrome, type B

Other names or spellings for Morquio syndrome, type B:

MPS IV Morqio Type B, Mucopolysaccharidosis type IV-B, Mucopolysaccharidosis 4B, Beta galactosidase deficiency, Morquio's disease type B, MPS IVB, MPS4B, Morquio syndrome B, Morquio B syndrome, Morquio-B disease

Mucopolysaccharidosis IVb, Generalized gangliosidosis GM1, Beta-galactosidase-1 deficiency Source - Diseases Database

Beta galactosidase deficiency, MPS IVB, MPS4B, Morquio B syndrome, Morquio syndrome B, Morquio's disease type B, Morquio-B disease, Mucopolysaccharidosis 4B
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Morquio syndrome, type B: Related Conditions

Research the causes of these diseases that are similar to, or related to, Morquio syndrome, type B:

 

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