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Mucopolysaccharidosis II

Mucopolysaccharidosis II: Introduction

Mucopolysaccharidosis II: MPS II, also called Hunter syndrome, affects juveniles and includes a mild and a severe form. Signs of the severe form ... more about Mucopolysaccharidosis II.

Mucopolysaccharidosis II: Disorder of mucopolysaccharide metabolism in juveniles. More detailed information about the symptoms, causes, and treatments of Mucopolysaccharidosis II is available below.

Symptoms of Mucopolysaccharidosis II

Treatments for Mucopolysaccharidosis II

Mucopolysaccharidosis II: Related Patient Stories

Mucopolysaccharidosis II: Deaths

Read more about Deaths and Mucopolysaccharidosis II.

Types of Mucopolysaccharidosis II

Mucopolysaccharidosis II: Complications

Read more about complications of Mucopolysaccharidosis II.

Causes of Mucopolysaccharidosis II

Read more about causes of Mucopolysaccharidosis II.

Disease Topics Related To Mucopolysaccharidosis II

Research the causes of these diseases that are similar to, or related to, Mucopolysaccharidosis II:

Evidence Based Medicine Research for Mucopolysaccharidosis II

Medical research articles related to Mucopolysaccharidosis II include:

Click here to find more evidence-based articles on the TRIP Database

Prognosis for Mucopolysaccharidosis II

Prognosis for Mucopolysaccharidosis II: Usually death by age 15 for severe form; can have normal lifespan for mild form.

Research about Mucopolysaccharidosis II

Visit our research pages for current research about Mucopolysaccharidosis II treatments.

Clinical Trials for Mucopolysaccharidosis II

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Mucopolysaccharidosis II include:

Statistics for Mucopolysaccharidosis II

Mucopolysaccharidosis II: Broader Related Topics

Mucopolysaccharidosis II Message Boards

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Article Excerpts about Mucopolysaccharidosis II

MPS II, also called Hunter syndrome, affects juveniles and includes a mild and a severe form. Signs of the severe form are joint stiffness, mental deterioration, dwarfing, and progressive deafness. Death usually occurs by age 15. Symptoms of the mild form include short stature, limitation of motion, and features such as an enlarged forehead, lips, and tongue and misaligned teeth. (Source: excerpt from NINDS Mucopolysaccharidoses Information Page: NINDS)

Definitions of Mucopolysaccharidosis II:

An inborn mucopolysaccharide metabolism disorder with iduronate-2-sulfatase deficiency. Clinical characteristics are similar to those in MPS I, except for the absence of corneal clouding and slower progression of the course of disease and central nervous system deterioration. Retinal degeneration may occur, but the cornea usually remains clear. Appearance is normal at birth with excessive growth taking place during first two years of life. Two types are recognized: A severe form (MPS IIA) which is characterized mainly by mental retardation and progressive physical deterioration and early death, and a mild form (MPS IIB) in which patients may survive into adulthood. MPS IIA usually occurs between 2 and 4 years of age with progressive deterioration, chronic diarrhea, recurrent ear infections, hearing impairment, communicating hydrocephalus with increased intracranial pressure, and death at about 10 and 15 years. Obstructive airway disease, cardiac valvular dysfunction, myocardial thickening, pulmonary hypertension, coronary disease, and myocardial infarction may be superimposed. MPS IIB is milder with preservation of intelligence. The symptoms usually include hearing impairment, carpal tunnel syndrome, joint stiffness, discrete corneal opacities, and papilledema. Death may occur in early adulthood, usually from airway obstruction or cardiac failure. - (Source - Diseases Database)

Mucopolysaccharidosis II is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Mucopolysaccharidosis II, or a subtype of Mucopolysaccharidosis II, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Mucopolysaccharidosis II as a "rare disease".
Source - Orphanet

 

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