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3TC

Introduction: 3TC

Description of 3TC

3TC: A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)
Source: Diseases Database

3TC: Related Topics

These medical condition or symptom topics may be relevant to medical information for 3TC:

Terms associated with 3TC:

Terms Similar to 3TC:

Source: Diseases Database

For a description of 3TC, see:

Source: CRISP

External links related to: 3TC

Source: Diseases Database

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