Alpha heavy chain disease

Introduction: Alpha heavy chain disease

Description of Alpha heavy chain disease

Alpha heavy chain disease: A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. -- 2004
Source: Diseases Database

Alpha heavy chain disease: Related Topics

These medical condition or symptom topics may be relevant to medical information for Alpha heavy chain disease:

• Heavy chain disease
• Heavy chain
• Chain
• Clonal
• Disorder
• Small
• Small syndrome
• Intestinal
• Intestinal symptoms (5299 causes)

Terms associated with Alpha heavy chain disease:

Terms Similar to Alpha heavy chain disease:

• IgA heavy chain disease
• Immunoproliferative small intestinal disease

Source: Diseases Database

External links related to: Alpha heavy chain disease

• heavy chain disease - General Practice Notebook

Source: Diseases Database

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