Amifostine

Introduction: Amifostine

Description of Amifostine

Amifostine: A phosphorylated aminosulfhydryl compound. After dephosphorylation by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, amifostine binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. (NCI04)
Source: Diseases Database

Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Source: MeSH 2007

Amifostine: Related Topics

These medical condition or symptom topics may be relevant to medical information for Amifostine:

• Compound
• Dephosphorylation
• Alkaline
• Phosphatase
• Thiol
• Metabolite
• Cytotoxic
• Platinum
• Cisplatin
• Radiation

Terms associated with Amifostine:

Terms Similar to Amifostine:

• Ethiofos
• Gammaphos

Source - MeSH 2007

Broader terms for Amifostine

• Organothiophosphorus Compounds

Source - MeSH 2007

Hierarchical classifications of Amifostine

The following list attempts to classify Amifostine into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Organic Chemicals
  • Organophosphorus Compounds
    • Organothiophosphorus Compounds
      • Amifostine

MeSH 2007 Hierarchy

• Organic Chemicals
  • Sulfur Compounds
    • Organothiophosphorus Compounds
      • Amifostine

External links related to: Amifostine

• CancerSourceMD.Com Drug Guide
• Ethyol Online, Description, Chemistry, Ingredients - Amifostine - RxList Monographs
• Newly Approved Drug Therapies (543): Ethyol (amifostine), U.S. Bioscience, Alza
• Newly Approved Drug Therapies (65): Ethyol (amifostine), Alza, U.S. Bioscience
• RxMed: Pharmaceutical Information - ETHYOL

Source: Diseases Database

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