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Asparaginase

Introduction: Asparaginase

Description of Asparaginase

Asparaginase: antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia.
Source: WordNet 2.1

Asparaginase: An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The E. carotovora-derived form of asparaginase is typically reserved for cases of hypersensitivity. (NCI04)
Source: Diseases Database

Asparaginase: EC 3.5.1.1.
Source: CRISP

Asparaginase: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Source: MeSH 2007

Asparaginase: Related Topics

These medical condition or symptom topics may be relevant to medical information for Asparaginase:

Drug name confusion

Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication. Other drugs that are sometimes confused with Asparaginase include:

Terms associated with Asparaginase:

Terms Similar to Asparaginase:

Source: Diseases Database

  • Elspar

Source - WordNet 2.1

Broader terms for Asparaginase

Source - MeSH 2007

Source - CRISP

Source - WordNet 2.1

The term Asparaginase can be used for:

Source: CRISP

Hierarchical classifications of Asparaginase

The following list attempts to classify Asparaginase into categories where each line is subset of the next.

WordNet 2.1

  • antineoplastic,antineoplastic drug,cancer drug
  • cytotoxic drug
  • medicament,medication,medicinal drug,medicine
  • drug
  • agent
  • causal agency,causal agent,cause
  • entity

Source: WordNet 2.1

MeSH 2007 Hierarchy:

External links related to: Asparaginase

Source: Diseases Database

Interesting Medical Articles:

Medical dictionaries:

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