Augmerosen

Introduction: Augmerosen

Description of Augmerosen

Augmerosen: A phosphorothioate antisense oligonucleotide. Targeted to the initiation codon region of the bcl-2 mRNA, oblimersen inhibits bcl-2 mRNA translation, resulting in decreased expression of the bcl-2 protein, an apoptotic inhibitor expressed in some types of cancer and linked to tumor drug resistance. This agent may enhance the efficacy of standard cytotoxic chemotherapy. (NCI04)
Source: Diseases Database

Augmerosen: Related Topics

These medical condition or symptom topics may be relevant to medical information for Augmerosen:

• Phosphorothioate
• Antisense
• Oligonucleotide
• Initiation
• Codon
• Region
• MRNA
• Oblimersen
• Translation
• Expression

Terms associated with Augmerosen:

Terms Similar to Augmerosen:

• bcl-2 antisense oligodeoxynucleotide (G3139)
• Oblimersen

Source: Diseases Database

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