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Cladribine

Introduction: Cladribine

Description of Cladribine

Cladribine: An anticancer drug that belongs to the family of drugs called antimetabolites.
Source: National Institute of Health

Cladribine: A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
Source: Diseases Database

Cladribine: An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Source: MeSH 2007

Cladribine: Related Topics

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Source: Diseases Database

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