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Dictionary » D4T


Introduction: D4T

Description of D4T

D4T: A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). (NCI04)
Source: Diseases Database

D4T: Related Topics

These medical condition or symptom topics may be relevant to medical information for D4T:

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Terms Similar to D4T:

Source: Diseases Database

The following terms can be used for D4T

Source: CRISP

External links related to: D4T

Source: Diseases Database

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