Dactinomycin

Introduction: Dactinomycin

Description of Dactinomycin

Dactinomycin: An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).actinomycins. SYN: actinomycin D.
Source: Stedman's Medical Spellchecker, © 2006 Lippincott Williams & Wilkins. All rights reserved.

Dactinomycin: A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
Source: Diseases Database

Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015).
Source: MeSH 2007

Dactinomycin: Related Topics

These medical condition or symptom topics may be relevant to medical information for Dactinomycin:

• Antineoplastic
• Antibiotic
• Streptomyces
• Actinomycins
• SYN
• Actinomycin

Drug name confusion

Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication. Other drugs that are sometimes confused with Dactinomycin include:

• Daunorubicin

Terms associated with Dactinomycin:

Terms Similar to Dactinomycin:

• Meractinomycin
• Actinomycin D

Source: Diseases Database

• Actinomycin
• Actinomycin D
• Meractinomycin

Source - MeSH 2007

Broader terms for Dactinomycin

• Heterocyclic Compounds, 3-Ring
• Peptides, Cyclic

Source - MeSH 2007

The following terms can be used for Dactinomycin

• actinomycin

Source: CRISP

Hierarchical classifications of Dactinomycin

The following list attempts to classify Dactinomycin into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Heterocyclic Compounds
  • Heterocyclic Compounds, 3-Ring
    • Dactinomycin

MeSH 2007 Hierarchy

• Polycyclic Compounds
  • Macrocyclic Compounds
    • Peptides, Cyclic
      • Dactinomycin

MeSH 2007 Hierarchy

• Amino Acids, Peptides, and Proteins
  • Peptides
    • Peptides, Cyclic
      • Dactinomycin

External links related to: Dactinomycin

• Cosmegen Lyovac , SPC from the eMC
• MedDet
• Systemic therapy for treating locoregional recurrence in women with breast cancer (Cochrane Review)
• CancerSourceMD.Com Drug Guide
• Cardioprotective interventions for cancer patients receiving anthracyclines (Cochrane Review)
• Cosmegen Online, Description, Chemistry, Ingredients - Dactinomycin - RxList Monographs

Source: Diseases Database

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• Medical Acronymns/Abbreviations

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Ontogenetic

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