Dexrazoxane

Introduction: Dexrazoxane

Description of Dexrazoxane

Dexrazoxane: A bisdioxopiperazine with antineoplastic activity and cardioprotective properties. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, thereby preventing the metal-catalyzed formation of reactive oxygen radicals produced by anthracycline antibiotics such as doxorubicin. This agent also inhibits the catalytic activity of topoisomerase II, resulting in cell growth inhibition. (NCI04)
Source: Diseases Database

Dexrazoxane: Related Topics

These medical condition or symptom topics may be relevant to medical information for Dexrazoxane:

• Antineoplastic
• Hydrolysis
• Form
• Acid
• EDTA
• Iron
• Iron disorder
• Metal
• Formation

External links related to: Dexrazoxane

• Cardioprotective interventions for cancer patients receiving anthracyclines (Cochrane Review)
• RxMed: Pharmaceutical Information - ZINECARD
• CancerSourceMD.Com Drug Guide
• Zinecard Online, Description, Chemistry, Ingredients - Dexrazoxane - RxList Monographs

Source: Diseases Database

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