Interleukin 12

Introduction: Interleukin 12

Description of Interleukin 12

Interleukin 12: Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
Source: Diseases Database

Interleukin 12: heterodimeric cytokine that stimulates the production of interferon gamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells; it is an initiator of cell-mediated immunity.
Source: CRISP

Interleukin 12: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Source: MeSH 2007

Interleukin 12: Related Topics

These medical condition or symptom topics may be relevant to medical information for Interleukin 12:

• Range
• Biological
• Disulfide
• Cytokine
• Subunit
• Type
• Receptor
• Family

Terms associated with Interleukin 12:

Terms Similar to Interleukin 12:

• Il12

Source: Diseases Database

Broader terms for Interleukin 12

• cytokine

Source - CRISP

Other terms that may be related to Interleukin 12:

• IP 10 protein

Source: CRISP

The description of Interleukin 12 may also be used for the following terms:

• IL12

Source: CRISP

External links related to: Interleukin 12

• OMIM - INTERLEUKIN 12A; IL12A

Source: Diseases Database

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