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Dictionary » Karenitecin
 

Karenitecin

Introduction: Karenitecin

Description of Karenitecin

Karenitecin: A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. (NCI04)
Source: Diseases Database

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