Leflunomide

Introduction: Leflunomide

Description of Leflunomide

Leflunomide: A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)
Source: Diseases Database

Leflunomide: Related Topics

These medical condition or symptom topics may be relevant to medical information for Leflunomide:

• Derivative
• Isoxazole
• Immunosuppressive
• Anti
• Anti pain
• Inflammatory
• Inflammatory symptoms (1736 causes)
• Inflammatory disease
• Prodrug

External links related to: Leflunomide

• Arava Online, Description, Chemistry, Ingredients - Leflunomide - RxList Monographs
• Arava 10, 20 and 100mg Tablets , SPC from the eMC
• Leflunomide for treating rheumatoid arthritis (Cochrane Review)

Source: Diseases Database

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