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Dictionary » Raltitrexed


Introduction: Raltitrexed

Description of Raltitrexed

Raltitrexed: A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)
Source: Diseases Database

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