Sirolimus

Introduction: Sirolimus

Description of Sirolimus

Sirolimus: A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibits antibody production. (NCI04)
Source: Diseases Database

Sirolimus: novel immunosuppressive drug used in transplantation; may inhibit receptor mediated activation of mast cells.
Source: CRISP

Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Source: MeSH 2007

Sirolimus: Related Topics

These medical condition or symptom topics may be relevant to medical information for Sirolimus:

• Lactone
• Bacterium
• Streptomyces
• Immunosuppressant
• Immunophilin
• Binding
• Protein
• Generate

Terms associated with Sirolimus:

Terms Similar to Sirolimus:

• Rapamycin

Source: Diseases Database

• rapamycin

Source - CRISP

Broader terms for Sirolimus

• immunosuppressive

Source - CRISP

The description of Sirolimus may also be used for the following terms:

• SDZ RAD

Source: CRISP

External links related to: Sirolimus

• Renal transplantation - immuno-suppressive regimens (adults) (No. 85)
• Rapamune Online, Description, Chemistry, Ingredients - Sirolimus - RxList Monographs
• Rapamune , SPC from the eMC

Source: Diseases Database

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