Temozolomide

Introduction: Temozolomide

Description of Temozolomide

Temozolomide: An anticancer drug that belongs to the family of drugs called alkylating agents.
Source: National Institute of Health

Temozolomide: An orally bioavailable triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound monomethyl triazeno imidazole carboxamide (MTIC); MTIC's cytotoxicity is due primarily to methylation of DNA at the O6 and N7 positions of guanine, which inhibits DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide penetrates well into the central nervous system. (NCI04)
Source: Diseases Database

Temozolomide: dacarbazine derivative; alkylating antineoplastic agent.
Source: CRISP

Temozolomide: Related Topics

These medical condition or symptom topics may be relevant to medical information for Temozolomide:

• Analog
• Dacarbazine
• Antineoplastic
• Cytotoxic
• Agent
• Physiologic
• Compound
• Imidazole
• Imidazole syndrome

Terms associated with Temozolomide:

Broader terms for Temozolomide

• antineoplastic

Source - CRISP

The term Temozolomide can be used for:

• methazolastone

Source: CRISP

The description of Temozolomide may also be used for the following terms:

• SCH52365

Source: CRISP

External links related to: Temozolomide

• CancerSourceMD.Com Drug Guide
• Temodar Online, Description, Chemistry, Ingredients - Temozolomide - RxList Monographs
• Brain cancer - temozolomide (No. 23)

Source: Diseases Database

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More Medical Dictionary Topics

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