Tetrahydrofolate dehydrogenase

Introduction: Tetrahydrofolate dehydrogenase

Description of Tetrahydrofolate dehydrogenase

Tetrahydrofolate dehydrogenase: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Source: MeSH 2007

Tetrahydrofolate dehydrogenase: Related Topics

These medical condition or symptom topics may be relevant to medical information for Tetrahydrofolate dehydrogenase:

• Tetrahydrofolate
• Dehydrogenase

Terms associated with Tetrahydrofolate dehydrogenase:

Terms Similar to Tetrahydrofolate dehydrogenase:

• Dihydrofolate Dehydrogenase
• Dihydrofolate Reductase
• Folic Acid Reductase

Source - MeSH 2007

Broader terms for Tetrahydrofolate dehydrogenase

• Oxidoreductases Acting on CH-NH Group Donors

Source - MeSH 2007

The following terms can be used for Tetrahydrofolate dehydrogenase

• dihydrofolate reductase

Source: CRISP

Hierarchical classifications of Tetrahydrofolate dehydrogenase

The following list attempts to classify Tetrahydrofolate dehydrogenase into categories where each line is subset of the next.

MeSH 2007 Hierarchy:

• Enzymes and Coenzymes
  • Enzymes
    • Oxidoreductases
      • Oxidoreductases Acting on CH-NH Group Donors
        • Tetrahydrofolate Dehydrogenase

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