Thrombospondin

Introduction: Thrombospondin

Description of Thrombospondin

Thrombospondin: multifunctional glycoprotein secreted by endothelial cells and by alpha granules of platelets following activation by thrombin; interacts with a wide variety of molecules to play a role in platelet aggregation, tumor metastasis, vascular smooth muscle growth, and microorganism adhesion.
Source: CRISP

Thrombospondin: A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, vascular smooth muscle growth, and tissue repair.
Source: MeSH 2007

Thrombospondin: Related Topics

These medical condition or symptom topics may be relevant to medical information for Thrombospondin:

• Glycoprotein
• Endothelial
• Platelets
• Activation
• Thrombin
• Play
• Role
• Platelet
• Platelet symptoms (301 causes)

Terms associated with Thrombospondin:

Broader terms for Thrombospondin

• cell adhesion molecule
• extracellular matrix protein

Source - CRISP

The term Thrombospondin can be used for:

• glycoprotein G

Source: CRISP

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