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Tight junction: area of closely apposed plasma membranes of two adjacent animal cells; lateral diffusion of proteins within the lipid bilayer is reduced and intercellular exchange of solutes is enhanced.
Tight junction: Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22).
Source: MeSH 2007
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