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Toll-like receptor: activates signal transduction pathways that result in transcriptional regulation and stimulate immune function; activates innate immunity as well as stimulating the antigen-specific immune response and triggering the inflammatory response; conveys signals stimulated by factors such as lipopolysaccharides, bacterial lipoproteins, peptidoglycans and also CpG nucleic acids.
Toll-like receptor: A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.
Source: MeSH 2007
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